Type 2 Diabetes Mellitus Collaborative Genetic Study on Non-aboriginal Taiwanese
NCT ID: NCT01250639
Last Updated: 2010-12-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
5000 participants
OBSERVATIONAL
2010-08-31
2013-12-31
Brief Summary
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Detailed Description
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A genome-wide case-control association study will be adopted. Approximately five thousand of T2DM subjects whose age is equal to or above twenty will be recruited by study physicians in the out-patient-department in CMUH and CCH. In addition, relatives of T2DM subjects with a positive family history, in which at least three family members are affected with T2DM within five generations, will be recruited by study nurses. An age-, sex-, and ethnicity-matched control will be selected randomly from the Cell Bank and Genetic Database on Non-Aboriginal Taiwanese. After obtaining informed consent, the medical history questionnaire and family background will be completed by the subjects. The subjects will be invited for a health check-up which include blood pressure, body weight, body height, waist circumference and hip circumference, as well as an ophthalmic check-up. A 15 ml of blood will be drawn from the subject for measurements of Cholesterol, HDLc, LDLc, TG, Fasting Plasma Glucose, Insulin, HbA1c, CBC without differential count, Electrolytes (Ca2+ , Na+, K+, Cl-), BUN, Creatinine, SGOT, SGPT, C-peptide, Uric Acid and CRP, as well as DNA extraction. A urine sample collection will also be requested from the subject for evaluation of urine protein, ketone body, glucose, micro albumine and creatinine.
This genome-wide association study aims to investigate the disease causing variants/genes of T2DM and diabetic subphenotypes as well as the underlying mechanisms in T2DM pathogenesis. Hopefully, early diagnostic markers and new therapies will be developed based on the genetic etiology and toward the personalized medicine in the future.
Conditions
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Keywords
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Study Design
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CASE_CONTROL
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* Subject must satisfy the diagnostic criteria for T2D at the time of examination.
* Subject is willing to participate and capable of giving informed consent.
* Subject is a self reported non-aboriginal Taiwanese, and none of the parents and grand-parents has aboriginal background.
* Relatives of T2DM subjects with a positive family history are willing to participate and capable of giving informed consent.
Exclusion Criteria
* Gestational Diabetes
* Monogenic Diabetes
* Subject is unable to understand or give informed consent.
20 Years
ALL
No
Sponsors
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Academia Sinica, Taiwan
OTHER
China Medical University Hospital
OTHER
Responsible Party
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Fuu-Jen Tsai
Principal Investigators
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Fuu-Jen Tsai, PHD
Role: PRINCIPAL_INVESTIGATOR
Division of Metabolism and Endocrinology
Locations
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China Medical University Hospital
Taichung, Taiwan, Taiwan
Countries
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Central Contacts
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Facility Contacts
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Fuu-Jen Tsai, PHD
Role: primary
Other Identifiers
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DMR99-IRB-164
Identifier Type: -
Identifier Source: org_study_id