Effect of Stopping Risedronate After Long Term Treatment on Bone Turnover

NCT ID: NCT01249261

Last Updated: 2011-11-02

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

61 participants

Study Classification

INTERVENTIONAL

Study Start Date

2001-10-31

Study Completion Date

2003-05-31

Brief Summary

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The effects of stopping long-term (7 years) and short term (2 years) risedronate therapy on BMD (bone mineral density) and BTMs (bone turnover markers) will be summarized.

Detailed Description

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Conditions

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Postmenopausal Women With Osteoporosis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Placebo/Risedronate

Placebo years 1-5, Risedronate 5mg/day years 6 \& 7, no drug year 8

Group Type PLACEBO_COMPARATOR

Placebo/Risedronate

Intervention Type DRUG

placebo years 1-5 followed by 5 mg risedronate years 6 \& 7 and no drug year 8

Risedronate

Risedronate 5mg years 1-7, no drug year 8

Group Type ACTIVE_COMPARATOR

Risedronate

Intervention Type DRUG

5 mg/day

Interventions

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Risedronate

5 mg/day

Intervention Type DRUG

Placebo/Risedronate

placebo years 1-5 followed by 5 mg risedronate years 6 \& 7 and no drug year 8

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Post-menopausal women who sequentially completed studies RVE009093, RVE1996077, RVE1998080

Exclusion Criteria

* Less than 60% compliant between drug start and month 21
* Using bisphosphonates, glucocorticoids, anabolic steroids, vitamin D supplements, calcitrol, estrogen or estrogen-related drugs, progestogen, depot injection \>10,000 IU vitamin D, investigational drug
Maximum Eligible Age

85 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Warner Chilcott

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Herman Ellman, MD

Role: STUDY_DIRECTOR

Warner Chilcott

Locations

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Investigational Site

Concord, New South Wales, Australia

Site Status

Investigational Site

Parkville, Victoria, Australia

Site Status

Investigational Site

De Pintelaan 185, Gent, Belgium

Site Status

Investigational Site

Hvidovre, Denmark, Denmark

Site Status

Investigational Site

Oulu, Finland, Finland

Site Status

Investigational Site

Siena, Italy, Italy

Site Status

Investigational Site

Warsaw, Poland, Poland

Site Status

Investigational Site

Warsaw, Poland, Poland

Site Status

Investigational Site

Warsaw, Poland, Poland

Site Status

Investigational Site

Warsaw, Poland, Poland

Site Status

Investigational Site

Barcelona, Spain, Spain

Site Status

Investigational Site

Madrid, Spain, Spain

Site Status

Investigational Site

Gothenburg, Sweden, Sweden

Site Status

Countries

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Australia Belgium Denmark Finland Italy Poland Spain Sweden

Other Identifiers

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2001079

Identifier Type: -

Identifier Source: org_study_id