Expression of Optic Atrophy Type 1 (OPA1) Protein in Lung Adenocarcinoma

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-08-31

Brief Summary

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Optic atrophy type 1(OPA1) is a nuclear dynamin-related GTPase, targeted to the inner mitochondrial membrane, which plays a role in mitochondrial fusion. Mitochondria fusion is associated with process of apoptosis. . OPA1 plays an important role in the mitochondrial bioenergetics and mitochondrial networks. The changes in mitochondrial shape and mitochondrial bioenergetics may be cause of the disease. In this study, we investigate the expression of OPA1 in lung adenocarcinoma (LADC) cells and tissue.

Detailed Description

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Conditions

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Lung Adenocarcinoma

Keywords

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OPA1 lung adenocarcinomas Prognosis Expression of optic atrophy type 1 (OPA1) protein in lung adenocarcinoma

Study Design

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Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* We will collect paraffin blocked resected lung tissue samples from stage I\~IIIa non-small cell lung cancer patients (age, 40\~80 years old) who received lobectomy of the affected lung.

Exclusion Criteria

* History of uremia, other malignant disease, and liver cirrhosis
* History of pneumonia and pulmonary tuberculosis
* History of long period of medications.

Minimum Eligible Age

25 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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China Medical University Hospital

Locations

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Fang Hsin Yuan

Taichung, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Facility Contacts

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Hsin-Yuan Fang, MD

Role: primary

Other Identifiers

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DMR99-IRB-062

Identifier Type: -

Identifier Source: org_study_id