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Pringle Time Exceeding 120 Min in Liver Resection

NCT ID: NCT01237002

Last Updated: 2010-11-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

189 participants

Study Classification

OBSERVATIONAL

Study Start Date

2005-01-31

Study Completion Date

2010-10-31

Brief Summary

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Intermittent Pringle's maneuver is widely used to limit blood loss during hepatectomy, without an established time-limit. However, many authors claims its danger for patients' outcome. The investigators check the short term outcome of a consecutive cohort of patients who underwent hepatectomy with intermittent clamping exceeding 120 minutes.

Detailed Description

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Conditions

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Tolerance of the Liver

Keywords

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Liver ischemia; Pringle time

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Group 1

117 patients with cumulative clamping time between 60 and 120 minutes

No interventions assigned to this group

Group 2

72 patients with cumulative clamping time longer than 120 minutes

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* patients in whom total cumulative clamping time exceeded 60 minutes.

Exclusion Criteria

* patients in whom total cumulative clamping time was less than 60 minutes
Minimum Eligible Age

29 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Milan

OTHER

Sponsor Role lead

Responsible Party

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Liver Surgery Unit, Third Department of Surgery, University of Milan, IRCCS Istituto Clinico Humanitas

Principal Investigators

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Guido Torzilli, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

IRCCS Istituto Clinico Humanitas

Locations

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IRCCS Istituto Clinico Humanitas

Rozzano, Milan, Italy

Site Status

Countries

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Italy

References

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Belghiti J, Noun R, Malafosse R, Jagot P, Sauvanet A, Pierangeli F, Marty J, Farges O. Continuous versus intermittent portal triad clamping for liver resection: a controlled study. Ann Surg. 1999 Mar;229(3):369-75. doi: 10.1097/00000658-199903000-00010.

Reference Type BACKGROUND
PMID: 10077049 (View on PubMed)

Elias D, Desruennes E, Lasser P. Prolonged intermittent clamping of the portal triad during hepatectomy. Br J Surg. 1991 Jan;78(1):42-4. doi: 10.1002/bjs.1800780115.

Reference Type BACKGROUND
PMID: 1998862 (View on PubMed)

Torzilli G, Procopio F, Donadon M, Del Fabbro D, Cimino M, Montorsi M. Safety of intermittent Pringle maneuver cumulative time exceeding 120 minutes in liver resection: a further step in favor of the "radical but conservative" policy. Ann Surg. 2012 Feb;255(2):270-80. doi: 10.1097/SLA.0b013e318232b375.

Reference Type DERIVED
PMID: 21975322 (View on PubMed)

Other Identifiers

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Pringle 120 minutes

Identifier Type: -

Identifier Source: org_study_id