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Development of New MRI Pulse Sequences for Probing Lung Function in Volunteers With Hyperpolarised 3He Gas

NCT ID: NCT01235494

Last Updated: 2021-12-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-07-31

Study Completion Date

2020-12-31

Brief Summary

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To develop techniques with MRI of Helium-3 gas to give functional images of the lungs. The goal is to test a single breath-hold functional 3-He MRI pulse sequence with sensitivity to multiple functional aspects of the luncg physiology. A group of 20 healthy volunteers willbe recruited from the local research group and the results compared with existing methods that require seperate breath-holds of 3He gas

Detailed Description

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Conditions

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Healthy Volunteers

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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polarised 3 helium

inhaled gas

Group Type EXPERIMENTAL

polarised 3 helium

Intervention Type OTHER

1 inhalation (= 1 litre)

Interventions

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polarised 3 helium

1 inhalation (= 1 litre)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* age 18 -70

Exclusion Criteria

* contraindication to MRI
* Resting oxygen saturation \<95%
* Volunteers requiring bronchodilators less than 4 hourly
* additional respiratory diagnoses
* pregnancy
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Sheffield

OTHER

Sponsor Role collaborator

Sheffield Teaching Hospitals NHS Foundation Trust

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Academic Unit of Radiology, Univeristy of Sheffield

Sheffield, South Yorkshire, United Kingdom

Site Status

Countries

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United Kingdom

Other Identifiers

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STH15080

Identifier Type: -

Identifier Source: org_study_id