Clinical Trial to Compare the Pharmacokinetics and Pharmacodynamics After Oral Administration of Glucophage and HL-018

NCT ID: NCT01232036

Last Updated: 2010-11-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-05-31

Study Completion Date

2010-10-31

Brief Summary

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This study is designed to to compare the pharmacokinetic and pharmacodynamic characteristics and safety after oral administration of Glucophage with those after oral administration of HL-018 in healthy male volunteers

Detailed Description

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Conditions

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Healthy

Keywords

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healthy volunteers

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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A

Reference

Group Type ACTIVE_COMPARATOR

Glucophage 500mg

Intervention Type DRUG

Single Oral Dose of

B

Test

Group Type EXPERIMENTAL

HL-018 500mg

Intervention Type DRUG

Single Oral Dose of

C

Placebo

Group Type PLACEBO_COMPARATOR

No administration of Drug

Intervention Type OTHER

Interventions

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Glucophage 500mg

Single Oral Dose of

Intervention Type DRUG

HL-018 500mg

Single Oral Dose of

Intervention Type DRUG

No administration of Drug

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Adult males aged 19 to 50 years at screening.
* No significant congenital/chronic disease. No symptoms in physical examination.
* Appropriate subjects as determined by past medical history, laboratory tests, serology and urinalysis.
* Be able to understand the objective, method of the study, the characteristics of investigational drug, and comply with the requirement of the study. Subject must provide written informed consent prior to study participation.

Exclusion Criteria

* History or presence of liver, kidney, or nervous system disease, respiratory disorders, endocrinological disorders, hemato-oncologic, cardiovascular or psychiatric or cognitive disorders.
* History of gastrointestinal disorders (bleeding, ulceration, hemorrhoids, piles) or disorders of absorption, distribution, metabolism, excretion.
* History of known hypersensitivity to drugs including metformin.
Minimum Eligible Age

19 Years

Maximum Eligible Age

50 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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HanAll BioPharma Co., Ltd.

INDUSTRY

Sponsor Role collaborator

Asan Medical Center

OTHER

Sponsor Role lead

Responsible Party

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HanAll Biopharma Co., Ltd.

Principal Investigators

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Kyun-Seop Bae, M.D., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Asan Medical Center

Locations

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Asan Medical Center

Seoul, , South Korea

Site Status

Countries

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South Korea

Related Links

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http://crc.amc.seoul.kr

Clinical Research Center, Asan Medical Center

Other Identifiers

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2010-0195

Identifier Type: -

Identifier Source: org_study_id