Clinical Study to Investigate the Safety and Pharmacokinetics of Udenafil Tablet in Renal Impaired Male Patients

NCT ID: NCT01231997

Last Updated: 2010-11-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

27 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-11-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study is designed to assess the effect of renal impairment on the pharmacokinetics, safety and tolerability of udenafil in subjects with renal impairment compared to healthy subjects.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Renal Insufficiency Kidney Diseases Urologic Diseases

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

Udenafil DA-8159 renal impairment healthy volunteers

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Healthy Volunteers

Group Type EXPERIMENTAL

Udenafil

Intervention Type DRUG

100mg Single Oral Dose of

Patients with mild renal impairment

Group Type EXPERIMENTAL

Udenafil

Intervention Type DRUG

100mg Single Oral Dose of

Patients with moderate renal impairment

Group Type EXPERIMENTAL

Udenafil

Intervention Type DRUG

100mg Single Oral Dose of

Patients with severe renal impairment

Group Type EXPERIMENTAL

Udenafil

Intervention Type DRUG

100mg Single Oral Dose of

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Udenafil

100mg Single Oral Dose of

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Adult males aged 19 to 64 years at screening.
* Subjects with body weight ≥ 55 kg and within ±30% of the ideal body weight : Ideal body weight = (height \[cm\] - 100)x0.9.
* Subjects who have received and understood completely the information regarding the current study and given written informed consents to voluntarily participate in the study and followed all instructions specified in the protocol.

Exclusion Criteria

* Subjects with the test results of QTc \> 430 ms or non-sinus cardiac rhythm by ECG analysis.
* Subjects with hypotension or hypertension.
* Subjects who have drunken habitually (exceeding 21 units/week, 1 unit = 10 g of pure alcohol) or who are unable to abstain from drinking during the study period from 2 days prior to the first administration of investigational product and during this study.
* Subjects deemed ineligible by investigator based on other reasons, including abnormal laboratory values or diseases.
Minimum Eligible Age

19 Years

Maximum Eligible Age

64 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Dong-A Pharmaceutical Co., Ltd.

INDUSTRY

Sponsor Role collaborator

Asan Medical Center

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Dong-A Pharmaceutical Co., Ltd.

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Kyun-Seop Bae, M.D., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Asan Medical Center

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Asan Medical Center

Seoul, , South Korea

Site Status

Countries

Review the countries where the study has at least one active or historical site.

South Korea

Related Links

Access external resources that provide additional context or updates about the study.

http://crc.amc.seoul.kr

Clinical Research Center, Asan Medical Center

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2006-0431

Identifier Type: -

Identifier Source: org_study_id