BIOmarkers of Dyspnea IN Emergency Room

NCT ID: NCT01227317

Last Updated: 2011-12-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

444 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-04-30

Study Completion Date

2011-09-30

Brief Summary

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The purpose of this study is to evaluate the capacity of some novels biomarkers Procalcitonin (PCT), Midregional Proadrenomedullin (MR pro ADM), Midregional pro-atrial natriuretic peptide (MR pro ANP), Copeptin (CT pro arginine vasopressin), Pro endothelin to stratify the risk in severe dyspnea.

Detailed Description

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In emergency department shortness of breath (SOB)is a common symptom and its cause is not easy to be identified. The risk stratifying remains a challenge, Prognostic value of biomarkers might be helpful.

Conditions

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Severe Dyspnea CAPD AE COPD Acute Heart Failure Pulmonary Embolism

Keywords

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Dyspnea Mortality

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Acute dyspnea in ED

Acute severe shortness of breath (SOB) in emergency Department (ED) with suspicion of acute heart failure (AHF) or Pulmonary Embolism (PE)or Community-acquired pneumonia (CAP) or acute Exacerbation of chronic obstructive pulmonary disease (AE COPD)

Prognostic value of Biomarkers

Intervention Type OTHER

Mr pro ADM, Mr pro ANP, PCT, Copeptin and pro endothelin value to stratify the risk in SOB patients

Interventions

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Prognostic value of Biomarkers

Mr pro ADM, Mr pro ANP, PCT, Copeptin and pro endothelin value to stratify the risk in SOB patients

Intervention Type OTHER

Other Intervention Names

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Dyspnea Prognostic value

Eligibility Criteria

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Inclusion Criteria

* tachypnea \> 25 /min or Pa02 \< 70 mmHg or SpO2 \< 93%
* diagnosis suspected: CAP, PE,EACOPD, AHF

Exclusion Criteria

* other cause of dyspnea,
* unreachable on Day 30
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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ThermoFisher Scientific Brahms Biomarkers France

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pierre Hausfater, Pr

Role: STUDY_CHAIR

ED Pitié SalpêtrièreHospital in Paris

Yann-Erick Claessens, Dr

Role: PRINCIPAL_INVESTIGATOR

ED Cochin Hospital in Paris

Guillaume Der Sahakian, Dr

Role: PRINCIPAL_INVESTIGATOR

ED Hotel Dieu Hospital in Paris

Arnaud Martinage, Dr

Role: PRINCIPAL_INVESTIGATOR

ED Hotel Dieu Hospital in Nantes

Fatima Rayeh, Dr

Role: PRINCIPAL_INVESTIGATOR

ED La Miletrie Hospital in Poitiers

Eric Weil, Pr

Role: PRINCIPAL_INVESTIGATOR

ED Hospital B in Lille

Luc-Marie JOLY, Dr

Role: PRINCIPAL_INVESTIGATOR

ED Charles Nicolle Hospital in Rouen

Locations

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Emergency department of Pitié Salpetriere Hospital

Paris, Paris, France

Site Status

Countries

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France

Other Identifiers

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BIODINER BRAHMS France

Identifier Type: -

Identifier Source: org_study_id