Trial Outcomes & Findings for Hoarding Older Adults (NCT NCT01227057)

Last Updated: 2018-07-24

Results Overview

Hoarding symptom severity (primary outcome) will be measured using the Savings Inventory-Revised (SI-R), a 23-item self-report measure used to assess common hoarding symptoms. Subtests include excessive clutter, compulsive acquisition, and difficulty discarding. The SI-R has demonstrated good internal consistency, divergent validity, concurrent validity, divergent validity, test-retest reliability in clinical samples with hoarding. The total score will be used for analyses. The range of the total score is 0-92, with higher scores indicating worse hoarding severity.

Recruitment status

COMPLETED

Study phase

Target enrollment

58 participants

Primary outcome timeframe

6 months

Results posted on

2018-07-24

Participant Flow

Participant milestones

Participant milestones
Measure	Arm 1: Cognitive Rehabilitation Cognitive rehabilitation and exposure therapy for hoarding Cognitive Rehabilitation and Exposure Therapy for Compulsive Hoarding: The intervention includes cognitive remediation for deficits in executive functioning and exposure therapy for discarding/acquiring.	Arm 2: Case Management Case Management: Case management
Overall Study STARTED	31	27
Overall Study COMPLETED	25	19
Overall Study NOT COMPLETED	6	8

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Hoarding Older Adults

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Arm 1: Cognitive Rehabilitation n=31 Participants Cognitive rehabilitation and exposure therapy for hoarding Cognitive Rehabilitation and Exposure Therapy for Compulsive Hoarding: The intervention includes cognitive remediation for deficits in executive functioning and exposure therapy for discarding/acquiring.	Arm 2: Case Management n=27 Participants Case Management: Case management	Total n=58 Participants Total of all reporting groups
Age, Continuous	69.35 years STANDARD_DEVIATION 6.49 • n=5 Participants	64.19 years STANDARD_DEVIATION 5.35 • n=7 Participants	66.95 years STANDARD_DEVIATION 6.48 • n=5 Participants
Sex: Female, Male Female	24 Participants n=5 Participants	17 Participants n=7 Participants	41 Participants n=5 Participants
Sex: Female, Male Male	7 Participants n=5 Participants	10 Participants n=7 Participants	17 Participants n=5 Participants
Race (NIH/OMB) American Indian or Alaska Native	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants
Race (NIH/OMB) Asian	2 Participants n=5 Participants	0 Participants n=7 Participants	2 Participants n=5 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants
Race (NIH/OMB) Black or African American	1 Participants n=5 Participants	0 Participants n=7 Participants	1 Participants n=5 Participants
Race (NIH/OMB) White	27 Participants n=5 Participants	24 Participants n=7 Participants	51 Participants n=5 Participants
Race (NIH/OMB) More than one race	0 Participants n=5 Participants	3 Participants n=7 Participants	3 Participants n=5 Participants
Race (NIH/OMB) Unknown or Not Reported	1 Participants n=5 Participants	0 Participants n=7 Participants	1 Participants n=5 Participants
Region of Enrollment United States	31 participants n=5 Participants	27 participants n=7 Participants	58 participants n=5 Participants
Saving Inventory Revised	57.35 units on a scale STANDARD_DEVIATION 10.23 • n=5 Participants	59.48 units on a scale STANDARD_DEVIATION 14.01 • n=7 Participants	58.34 units on a scale STANDARD_DEVIATION 12.08 • n=5 Participants
Clutter Image Rating	4.15 units on a scale STANDARD_DEVIATION 1.71 • n=5 Participants	4.33 units on a scale STANDARD_DEVIATION 2.11 • n=7 Participants	4.24 units on a scale STANDARD_DEVIATION 1.89 • n=5 Participants
University of California, Los Angeles Hoarding Severity Scale	26.35 units on a scale STANDARD_DEVIATION 5.31 • n=5 Participants	28.85 units on a scale STANDARD_DEVIATION 5.82 • n=7 Participants	27.52 units on a scale STANDARD_DEVIATION 5.65 • n=5 Participants
Activities of Daily Living - Hoarding	30.85 units on a scale STANDARD_DEVIATION 9.3 • n=5 Participants	31.90 units on a scale STANDARD_DEVIATION 13.53 • n=7 Participants	31.31 units on a scale STANDARD_DEVIATION 11.23 • n=5 Participants
Hospital Anxiety and Depression Hospital Anxiety and Depression - Anxiety	9.06 units on a scale STANDARD_DEVIATION 4.39 • n=5 Participants	10.15 units on a scale STANDARD_DEVIATION 3.41 • n=7 Participants	9.56 units on a scale STANDARD_DEVIATION 3.98 • n=5 Participants
Hospital Anxiety and Depression Hospital Anxiety and Depression - Depression	7.13 units on a scale STANDARD_DEVIATION 3.23 • n=5 Participants	8.56 units on a scale STANDARD_DEVIATION 4.97 • n=7 Participants	7.79 units on a scale STANDARD_DEVIATION 4.16 • n=5 Participants
Clinician Global Improvement - Severity scale	3.67 units on a scale STANDARD_DEVIATION .92 • n=5 Participants	3.96 units on a scale STANDARD_DEVIATION 1.19 • n=7 Participants	3.81 units on a scale STANDARD_DEVIATION 1.06 • n=5 Participants

PRIMARY outcome

Timeframe: 6 months

Outcome measures

Outcome measures
Measure	Arm 1: Cognitive Rehabilitation n=25 Participants Cognitive rehabilitation and exposure therapy for hoarding Cognitive Rehabilitation and Exposure Therapy for Compulsive Hoarding: The intervention includes cognitive remediation for deficits in executive functioning and exposure therapy for discarding/acquiring.	Arm 2: Case Management n=19 Participants Case Management: Case management
Hoarding Symptom Severity as Measured by the Saving Inventory-Revised (SI-R) at 6 Months	35.44 units on a scale Standard Deviation 15.48	44.68 units on a scale Standard Deviation 13.29

SECONDARY outcome

Timeframe: 6 months

The Activities of Daily Living in Hoarding (ADL-H) was used to assess functional impairment. Higher scores represent increased impairment. Mean score is 1-75, with higher scores indicating worse impairment due to hoarding.

Outcome measures

Outcome measures
Measure	Arm 1: Cognitive Rehabilitation n=25 Participants Cognitive rehabilitation and exposure therapy for hoarding Cognitive Rehabilitation and Exposure Therapy for Compulsive Hoarding: The intervention includes cognitive remediation for deficits in executive functioning and exposure therapy for discarding/acquiring.	Arm 2: Case Management n=19 Participants Case Management: Case management
The Activities of Daily Living in Hoarding (ADL-H)	21.09 units on a scale Standard Deviation 6.67	27.81 units on a scale Standard Deviation 14.29

SECONDARY outcome

Timeframe: 6 months

The D-KEFS Trail Making Test Condition 4: Number-Letter Switching Scaled Score was used to assess executive functioning. Scaled scores range from 1-19. Higher scores represent less impairment.

Outcome measures

Outcome measures
Measure	Arm 1: Cognitive Rehabilitation n=25 Participants Cognitive rehabilitation and exposure therapy for hoarding Cognitive Rehabilitation and Exposure Therapy for Compulsive Hoarding: The intervention includes cognitive remediation for deficits in executive functioning and exposure therapy for discarding/acquiring.	Arm 2: Case Management n=19 Participants Case Management: Case management
Executive Functioning as Measured by the Delis Kaplan Executive Functioning System (D-KEFS) at 6 Months	10.8 units on a scale Standard Deviation 3.67	10.8 units on a scale Standard Deviation 3.11

Adverse Events

Arm 1: Cognitive Rehabilitation

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Arm 2: Case Management

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Catherine Ayers

VASDHS

Phone: 8585528585

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place