Immunogenicity and Safety of a Booster Dose of Monovalent Glycoprotein-Conjugated (Diptheria Toxin -CRM197) Hib Vaccine in 365-569 Days Old Healthy Infants

NCT ID: NCT01226953

Last Updated: 2011-12-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

660 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-10-31

Study Completion Date

2011-03-31

Brief Summary

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This study will evaluate the safety and immunogenicity of booster dose of two commercially available vaccines used to prevent Haemophilus influenzae type b infections in children 365-569 days of age

Detailed Description

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Conditions

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Haemophilus Influenzae Type b (Hib) Infection

Keywords

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Haemophilus influenzae type b (Hib) Vaccine Anti-PRP antibody

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Arm 1

Group Type ACTIVE_COMPARATOR

Haemophilus influenzae type b (Hib) vaccine

Intervention Type BIOLOGICAL

Comparator study of two commercially available Haemophilus influenzae type b (Hib) vaccines

Arm 2

Group Type ACTIVE_COMPARATOR

Haemophilus influenzae type b (Hib) vaccine

Intervention Type BIOLOGICAL

Comparator study of two commercially available Haemophilus influenzae type b (Hib) vaccines

Interventions

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Haemophilus influenzae type b (Hib) vaccine

Comparator study of two commercially available Haemophilus influenzae type b (Hib) vaccines

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Infants 365-569 days of age.

Exclusion Criteria

* Subjects who already received a booster dose of Hib vaccine.
* History of serious reaction(s) following vaccination.
* Any vaccination within 7 days of study vaccination.
* Known or suspected immune impairment.
Minimum Eligible Age

365 Days

Maximum Eligible Age

569 Days

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Novartis Vaccines

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Hebei Province, , China

Site Status

Countries

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China

References

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Jun L, Yuguo C, Zhiguo W, Jinfeng L, Huawei M, Xiuhua L, Yonggui Z, Yanhua X, Kong Y, Hongtao L, Yuliang Z. Assessment of immunogenicity and safety following primary and booster immunisation with a CRM197 -conjugated Haemophilus influenzae type B vaccine in healthy Chinese infants. Int J Clin Pract. 2013 Oct;67(10):971-8. doi: 10.1111/ijcp.12267. Epub 2013 Aug 22.

Reference Type DERIVED
PMID: 23964690 (View on PubMed)

Other Identifiers

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V37_07E1

Identifier Type: -

Identifier Source: org_study_id