Effectiveness of Topical Glycerine Sulphate Paste, Hirudoid Cream and Nil Application on Superficial Phlebitis

NCT ID: NCT01226069

Last Updated: 2010-10-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

147 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-11-30

Study Completion Date

2010-02-28

Brief Summary

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The aim of the interventional study is to compare the different treatment modalities in reducing erythema size and rate of resolving phlebitis.

Detailed Description

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Conditions

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Infection

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Glycerine Magnesium Sulphate paste

Group Type ACTIVE_COMPARATOR

Glycerine Magnesium sulphate paste

Intervention Type DRUG

Dosage to apply adheres to the manufacturer's recommendation. Sufficient amount should cover the erythema size. Dose frequency is 12 hourly.

Hirudoid cream

Topical Mucopolysaccharide polysulphate

Group Type ACTIVE_COMPARATOR

Mucopolysaccharide polysulphate

Intervention Type DRUG

Dosage to apply adheres to the manufacturer's recommendation. Sufficient amount should cover the erythema size. Dose frequency is 12 hourly.

No application

Patient will not receive any topical application to apply on the phlebitis site. The outcome assessor will monitor regularly at pre-determined schedule as patients in other active arms.

Group Type EXPERIMENTAL

No application

Intervention Type OTHER

No application

Interventions

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Glycerine Magnesium sulphate paste

Dosage to apply adheres to the manufacturer's recommendation. Sufficient amount should cover the erythema size. Dose frequency is 12 hourly.

Intervention Type DRUG

Mucopolysaccharide polysulphate

Dosage to apply adheres to the manufacturer's recommendation. Sufficient amount should cover the erythema size. Dose frequency is 12 hourly.

Intervention Type DRUG

No application

No application

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients admitted to the study institution between Dec 2009 and Feb 2010 and observed to develop redness associated with peripheral infusion cannula.

Exclusion Criteria

* Thrombosis, poor skin condition, and pus seen at the previous puncture.
Minimum Eligible Age

21 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Tan Tock Seng Hospital

OTHER

Sponsor Role lead

Responsible Party

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Tan Tock Seng Hospital

Principal Investigators

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Isabel Ng, MSc Epidemiology

Role: PRINCIPAL_INVESTIGATOR

Tan Tock Seng Hospital

Locations

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Tan Tock Seng Hospital

Singapore, Singapore, Singapore

Site Status

Countries

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Singapore

References

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dos Reis PE, Silveira RC, Vasques CI, de Carvalho EC. Pharmacological interventions to treat phlebitis: systematic review. J Infus Nurs. 2009 Mar-Apr;32(2):74-9. doi: 10.1097/NAN.0b013e318198d497.

Reference Type RESULT
PMID: 19289920 (View on PubMed)

Almenar L, Hernandez M, Gimeno JV, Palencia M, Algarra F. [Heparinoids versus nitroglycerin in the treatment of superficial phlebitis]. Rev Clin Esp. 1993 Oct;193(5):229-31. Spanish.

Reference Type RESULT
PMID: 8256008 (View on PubMed)

Cokmez A, Gur S, Genc H, Deniz S, Tarcan E. Effect of transdermal glyceryl trinitrate and anti-inflammatory gel in infusion phlebitis. ANZ J Surg. 2003 Oct;73(10):794-6. doi: 10.1046/j.1445-2197.2003.02791.x.

Reference Type RESULT
PMID: 14525568 (View on PubMed)

Gouping Z, Wan-Er T, Xue-Ling W, Min-Qian X, Kun F, Turale S, Fisher JW. Notoginseny cream in the treatment of phlebitis. J Infus Nurs. 2003 Jan-Feb;26(1):49-54. doi: 10.1097/00129804-200301000-00007.

Reference Type RESULT
PMID: 12544367 (View on PubMed)

Vilardell M, Sabat D, Arnaiz JA, Bleda MJ, Castel JM, Laporte JR, Vallve C. Topical heparin for the treatment of acute superficial phlebitis secondary to indwelling intravenous catheter. A double-blind, randomized, placebo-controlled trial. Eur J Clin Pharmacol. 1999 Feb;54(12):917-21. doi: 10.1007/s002280050575.

Reference Type RESULT
PMID: 10192751 (View on PubMed)

Gua H, Li Y-J, Ma H-J. Efficacy observation of glycerine magnesium sulphate emulsion on the treatment of phlebitis. Journal of Lanzhou University (Medical Sciences). 2007;33(2):67-69.

Reference Type RESULT

Other Identifiers

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D/09/481

Identifier Type: -

Identifier Source: org_study_id