Vitamin/Mineral Supplement for Children and Adults With Autism

NCT ID: NCT01225198

Last Updated: 2010-10-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

143 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-05-31

Study Completion Date

2009-02-28

Brief Summary

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The investigators hypothesis is that a new, revised formulation of a vitamin/mineral supplement will result in:

1. improvement of nutritional status in some children/adults with autism, and
2. reduction of some of the symptoms of autism in some children

Detailed Description

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The major goal of this study is to determine the effect of this vitamin/mineral supplement on levels of vitamins, minerals, neurotransmitters, and biomarkers for nutritional deficiencies. The study design is a randomized, double-blind, placebo-controlled. Blood and urine measurements will be measured at the beginning of the study in children with autism and typical children. Then, the children with autism will be given the supplement or placebo for 12 weeks, and then their blood and urine will be re-measured.

Conditions

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Autism

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Placebo Group

Liquid placebo with identical packaging and flavoring to the real supplement.

Group Type PLACEBO_COMPARATOR

Liquid Placebo

Intervention Type OTHER

The placebo was formulated to look and taste like the intervention supplement. A small amount of beta-carotene was used for coloring. Natural cherry, citric acid, and a proprietary blend of natural flavors were used for flavoring to create a vitamin-like after-taste. Sucralose was used as a sweetener and the same preservatives were included (potassium sorbate, sodium benzoate).

Vitamin/Mineral Supplement Group

Multi-vitamin/mineral supplement designed for this study for children and adults with autism spectrum disorders.

Group Type EXPERIMENTAL

Multi-Vitamin/Mineral Supplement

Intervention Type DIETARY_SUPPLEMENT

A broad-spectrum vitamin/mineral supplement designed for children and adults with autism

Interventions

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Multi-Vitamin/Mineral Supplement

A broad-spectrum vitamin/mineral supplement designed for children and adults with autism

Intervention Type DIETARY_SUPPLEMENT

Liquid Placebo

The placebo was formulated to look and taste like the intervention supplement. A small amount of beta-carotene was used for coloring. Natural cherry, citric acid, and a proprietary blend of natural flavors were used for flavoring to create a vitamin-like after-taste. Sucralose was used as a sweetener and the same preservatives were included (potassium sorbate, sodium benzoate).

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. age 3-60 years old;
2. Autism Group: diagnosis of autism, pervasive developmental disorder/not otherwise specified (PDD/NOS), or Asperger's by a psychiatrist or similar professional
3. Control Group: in good mental and physical health, and no siblings with autism spectrum disorders, and no evidence of Attention Deficit Disorder by parent report

Exclusion Criteria

1. Usage of a vitamin/mineral supplement in the last 2 months
2. Current use of any chelation treatment
Minimum Eligible Age

3 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Autism Research Institute

UNKNOWN

Sponsor Role collaborator

Legacy Foundation

UNKNOWN

Sponsor Role collaborator

Arizona State University

OTHER

Sponsor Role lead

Responsible Party

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Arizona State University

Principal Investigators

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James B. Adams, PhD

Role: PRINCIPAL_INVESTIGATOR

Arizona State University

Locations

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Arizona State University

Tempe, Arizona, United States

Site Status

Countries

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United States

References

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Adams JB, Audhya T, McDonough-Means S, Rubin RA, Quig D, Geis E, Gehn E, Loresto M, Mitchell J, Atwood S, Barnhouse S, Lee W. Effect of a vitamin/mineral supplement on children and adults with autism. BMC Pediatr. 2011 Dec 12;11:111. doi: 10.1186/1471-2431-11-111.

Reference Type DERIVED
PMID: 22151477 (View on PubMed)

Related Links

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http://autism.asu.edu

Arizona State University Autism/Asperger's Research Program

Other Identifiers

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AutismVitaminStudy2008

Identifier Type: -

Identifier Source: org_study_id