Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
150 participants
INTERVENTIONAL
2010-10-31
2028-12-31
Brief Summary
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Ectopic lipid depositions, defined as an excess accumulation of triglycerides in non adipose tissues such as in the liver (intrahepatic lipids) and within the muscle fibers (intramyocellular lipids), are positively associated with obesity and insulin resistance. Furthermore, the accumulation of intracellular lipids is often cited as being a key determinant in the underlying mechanisms of insulin resistance. In addition of playing an important role in obesity and type 2 diabetes, these ectopic fat depositions are also observed in common conditions such as aging and physical inactivity.
The intervention trial will test in skeletal muscle, liver and heart of sedentary obese volunteers, normal weight volunteers and masters athletes, the overall hypotheses that exercise improvement of fat oxidation capacity and/or decrease of damaging fat metabolites is a primary factor that predicts the improvement in insulin resistance.
Detailed Description
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Conditions
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Keywords
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Study Design
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NON_RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Sedentary obese
Physical activity
Supervised exercise intervention
Sedentary normal weight
Physical activity
Supervised exercise intervention
Athletes
No interventions assigned to this group
Interventions
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Physical activity
Supervised exercise intervention
Eligibility Criteria
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Inclusion Criteria
* Sedentary or highly trained
* BMI 18-40
* Non-Smoker
* Normal glucose tolerance or impaired glucose tolerance
* Willingness to comply with the protocol
Exclusion Criteria
* Recent weight loss or weight gain
* Known diabetes
* Known drugs to affect glucose homeostasis such as nicotinic acid, glucocorticoids
* Severe anemia or lipid disturbances, hepatic or renal disease
* Recent history of cancer
* Hypothyroidism
* Recent hormone replacement therapy
* Known allergy to lidocaine or other local anesthetic
* Positive stress test
* Active alcohol or substance abuse
60 Years
80 Years
ALL
Yes
Sponsors
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Centre Hospitalier Universitaire Vaudois
OTHER
University of Lausanne
OTHER
Responsible Party
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Francesca Amati
Associate Professor
Principal Investigators
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Francesca Amati, MD,PhD
Role: PRINCIPAL_INVESTIGATOR
University of Lausanne
Locations
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University of Bern
Bern, , Switzerland
UNIL and CHUV
Lausanne, , Switzerland
Countries
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Central Contacts
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Facility Contacts
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Francesca Amati, MD, PhD
Role: primary
References
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Greggio C, Jha P, Kulkarni SS, Lagarrigue S, Broskey NT, Boutant M, Wang X, Conde Alonso S, Ofori E, Auwerx J, Canto C, Amati F. Enhanced Respiratory Chain Supercomplex Formation in Response to Exercise in Human Skeletal Muscle. Cell Metab. 2017 Feb 7;25(2):301-311. doi: 10.1016/j.cmet.2016.11.004. Epub 2016 Dec 1.
Broskey NT, Boss A, Fares EJ, Greggio C, Gremion G, Schluter L, Hans D, Kreis R, Boesch C, Amati F. Exercise efficiency relates with mitochondrial content and function in older adults. Physiol Rep. 2015 Jun;3(6):e12418. doi: 10.14814/phy2.12418.
Broskey NT, Greggio C, Boss A, Boutant M, Dwyer A, Schlueter L, Hans D, Gremion G, Kreis R, Boesch C, Canto C, Amati F. Skeletal muscle mitochondria in the elderly: effects of physical fitness and exercise training. J Clin Endocrinol Metab. 2014 May;99(5):1852-61. doi: 10.1210/jc.2013-3983. Epub 2014 Jan 17.
Broskey NT, Daraspe J, Humbel BM, Amati F. Skeletal muscle mitochondrial and lipid droplet content assessed with standardized grid sizes for stereology. J Appl Physiol (1985). 2013 Sep 1;115(5):765-70. doi: 10.1152/japplphysiol.00063.2013. Epub 2013 Jun 20.
Amati F, Broskey NT, Carnero EA. Evidence of systematic and proportional error in a widely used glucose oxidase analyser: impact for clinical research? Clin Endocrinol (Oxf). 2014 May;80(5):768-70. doi: 10.1111/cen.12274. Epub 2013 Jul 19. No abstract available.
Other Identifiers
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Protocol 188/10
Identifier Type: OTHER
Identifier Source: secondary_id
AGIR
Identifier Type: -
Identifier Source: org_study_id