Safety and Tolerability Study of Ragweed SLIT Tablets

NCT ID: NCT01224834

Last Updated: 2010-11-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-01-31

Study Completion Date

2009-10-31

Brief Summary

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The purpose of this study is to determine the safety and tolerability of several doses of ragweed pollen allergen extract administered as sublingual tablets in subjects with allergic rhinitis to ragweed.

Detailed Description

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Conditions

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Rhinitis, Allergic, Seasonal Ragweed Pollen Allergy

Keywords

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Ragweed, allergy, sublingual immunotherapy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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1

Group Type PLACEBO_COMPARATOR

Sublingual tablet of ragweed pollen allergen extract

Intervention Type DRUG

administered once a day over 10 days

2

Group Type EXPERIMENTAL

Sublingual tablet of ragweed pollen allergen extract

Intervention Type DRUG

administered once a day over 10 days

Interventions

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Sublingual tablet of ragweed pollen allergen extract

administered once a day over 10 days

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* written consent
* male or female subjects from 18 yo 60 years old and in general good health
* for women of child bearing potential: negative urine pregnancy test and use of medically effective contraceptive method
* symptoms of ragweed pollen induced allergic rhinitis for at least the last 2 years
* sensitization to ragweed pollen as demonstrated with positive skin prick test to ragweed pollen and specific IgE level (ragweed pollen) \> 0.70 kU/l at screening
* FEV1 at least of 80% of predicted value at screening

Exclusion Criteria

* past or current disease which, as judged by the investigator, may affect the outcome of this study
* history of life-threatening asthma
* asthma requiring daily treatment (whatever the pharmaceutical class)
* pregnant or lactating women
* subjects who previously received desensitisation treatment to ragweed pollen and/or other Asteraceae or who plan to start desensitisation treatment during this study
* symptoms during the treatment phase due to a sensitivity to a second allergen
* subjects treated with ongoing immunotherapy with another allergen
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Quintiles, Inc.

INDUSTRY

Sponsor Role collaborator

Stallergenes Greer

INDUSTRY

Sponsor Role lead

Responsible Party

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Stallergenes SA

Principal Investigators

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Eva Péterfai, MD

Role: PRINCIPAL_INVESTIGATOR

DRC Drug Research Center, Balatonfüred - Hungary

Locations

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DRC Drug Research Center

Balatonfüred, , Hungary

Site Status

Countries

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Hungary

Other Identifiers

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VO63.08 HUN

Identifier Type: -

Identifier Source: org_study_id