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Liver Regeneration After Liver Resection

NCT ID: NCT01220986

Last Updated: 2010-10-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-08-31

Study Completion Date

2012-08-31

Brief Summary

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The aim of this study is to characterize Kupffer cell activity and activation of the innate immune response in the early phase of liver regeneration after right hepatectomy. The investigators hypothesise that liver regeneration after right hepatectomy in humans is associated with Kupffer cell activation and initiation of the innate immune response and that impaired liver regeneration, liver failure and sepsis following liver resection are associated with Kupffer cell dysfunction and an impaired innate immune response. The objectives for this study are to characterise Kupffer cell activity and the innate immune response in human liver before and after right hepatectomy.

Detailed Description

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Conditions

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Liver Diseases Hepatectomy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Right hepatectomy

Intervals from inflow division.

Liver biopsy

Intervention Type PROCEDURE

0, 30, 60, 90 min post inflow-division

Interventions

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Liver biopsy

0, 30, 60, 90 min post inflow-division

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients requiring right hepatectomy for colorectal liver metastases

Exclusion Criteria

* Age \>75, neoadjuvant chemotherapy, recurrent disease
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nottingham University Hospitals NHS Trust

OTHER

Sponsor Role lead

Responsible Party

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Division of Surgery, NIHR Nottingham Digestive Diseases Centre BRU

Principal Investigators

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Dileep N. Lobo, DM FRCS

Role: STUDY_CHAIR

Reader in Surgery

Locations

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Nottingham University Hospitals NHS Trust, Queens Medical Centre Campus

Nottingham, Nottinghamshire, United Kingdom

Site Status RECRUITING

Countries

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United Kingdom

Central Contacts

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John S Hammond, BM.BS PhD

Role: CONTACT

[email protected]
01159249924 ext. 70607

Other Identifiers

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NDDC10/H0403/32

Identifier Type: -

Identifier Source: org_study_id