Radiation Therapy With or Without Chemotherapy in Treating Patients With High-Risk Malignant Salivary Gland Tumors That Have Been Removed By Surgery

NCT ID: NCT01220583

Last Updated: 2025-02-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE2

Total Enrollment

252 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-01-31

Study Completion Date

2028-10-31

Brief Summary

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RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether radiation therapy is more effective when given together with chemotherapy or alone after surgery in treating salivary gland tumors.

PURPOSE: This randomized phase II/III trial is studying radiation therapy with or without chemotherapy to see how well it works in treating patients with high-risk malignant salivary gland tumors that have been removed by surgery.

Detailed Description

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OBJECTIVES:

Primary

Phase II

* Determine the feasibility of conducting a cooperative group prospective clinical trial in patients with resected malignant salivary gland tumors.
* Acquire preliminary efficacy data comparing postoperative radiotherapy alone to concurrent chemotherapy and radiation using weekly cisplatin.

Phase III

\* Compare overall survival rates among patients receiving cisplatin and radiation to those receiving radiation alone.

Secondary

Phase II/III

* Compare the acute toxicities of these 2 adjuvant treatments.
* Compare late treatment-related adverse events in patients receiving postoperative radiation to those receiving concurrent chemoradiation.
* Compare progression-free survival rates among patients receiving cisplatin and radiation to those receiving radiation alone in both the cohort of patients with pathologically high-risk disease (high-grade adenocarcinoma, high-grade mucoepidermoid carcinoma, salivary duct carcinoma), and the patient cohort with pathologically intermediate-risk disease (all other eligible diagnoses).
* Investigate quality of life and patient-reported outcomes in patients enrolled in the study.
* Identify the histopathology and tumor marker expression from patients enrolled on this trial and assemble a tissue bank for future correlative studies.
* Establish a NRG Oncology baseline database for salivary gland malignancies to serve as a resource for future exploration of innovative and/or targeted approaches for this disease.

OUTLINE: This is a multicenter study. Patients are stratified according to histology (high-grade mucoepidermoid carcinoma vs salivary duct carcinoma vs high-grade adenocarcinoma) and nodal status (N0 vs N1-3). Patients are randomized to 1 of 2 treatment arms.

* Arm I: Patients undergo 3-dimensional conformal radiotherapy (3D-CRT) or intensity-modulated radiotherapy (IMRT) 5 days a week for 6-6.5 weeks. Patients also receive cisplatin IV over 60 minutes on days 1, 8, 15, 22, 29, 36, and 43 during radiotherapy.
* Arm II: Patients undergo 3D-CRT or IMRT as in Arm I. Tissue and blood samples may be collected for translational research studies. Patients may complete quality-of-life assessments periodically.

After completion of study treatment, patients are followed up at 3, 6, 9, 12, and 24 months, every 6 months for 2 years, and then annually thereafter.

Conditions

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Head and Neck Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Arm I

Patients undergo 3-dimensional conformal radiotherapy (3D-CRT) or intensity-modulated radiotherapy (IMRT) 5 days a week for 6-6.5 weeks. Patients also receive cisplatin IV over 60 minutes on days 1, 8, 15, 22, 29, 36, and 43 during radiotherapy.

Group Type EXPERIMENTAL

cisplatin

Intervention Type DRUG

Given IV

3-dimensional conformal radiation therapy

Intervention Type RADIATION

Undergo radiotherapy

intensity-modulated radiation therapy

Intervention Type RADIATION

Undergo radiotherapy

Arm II

Patients undergo 3D-CRT or IMRT as in arm I.

Group Type EXPERIMENTAL

3-dimensional conformal radiation therapy

Intervention Type RADIATION

Undergo radiotherapy

intensity-modulated radiation therapy

Intervention Type RADIATION

Undergo radiotherapy

Interventions

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cisplatin

Given IV

Intervention Type DRUG

3-dimensional conformal radiation therapy

Undergo radiotherapy

Intervention Type RADIATION

intensity-modulated radiation therapy

Undergo radiotherapy

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

DISEASE CHARACTERISTICS:

* Pathologically proven diagnosis of a malignant major salivary gland tumor or malignant minor salivary gland tumor of the head and neck of the following histologic subtypes:

* Intermediate-grade adenocarcinoma or intermediate-grade mucoepidermoid carcinoma
* High-grade acinic cell carcinoma or high-grade (\>30% solid component) adenoid cystic carcinoma
* Surgical resection with curative intent within 8 weeks prior to registration
* All patients must have a Medical Oncology evaluation within 4 weeks prior to registration
* Pathologic stage T3-4 or N1-3 or T1-2, N0 with a close (≤ 1mm) or microscopically positive surgical margin; patients must be free of distant metastases based upon the following minimum diagnostic workup:

* History/physical examination within 8 weeks prior to registration
* Radiologic confirmation of the absence of hematogenous metastasis within 12 weeks prior to registration; at a minimum, contrast CT imaging of the chest is required (PET/CT is acceptable)
* No patients with residual macroscopic disease after surgery
* No prior systemic chemotherapy or radiation therapy for salivary gland malignancy

PATIENT CHARACTERISTICS:

* Zubrod performance status 0-1
* Absolute neutrophil count (ANC) ≥ 1,800 cells/mm\^3
* Platelets ≥ 100,000 cells/mm\^3
* Hemoglobin ≥ 8.0 g/dL (the use of transfusion or other intervention to achieve hemoglobin ≥ 8.0 g/dL is acceptable)
* Serum creatinine \< 2.0 mg/dL
* Total bilirubin \< 2 x the institutional upper limit of normal (ULN)
* Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) \< 3 x the institutional ULN
* Negative serum pregnancy test within 2 weeks prior to registration for women of childbearing potential
* Women of childbearing potential and male participants who are sexually active must practice adequate contraception during treatment and for 6 weeks following treatment
* Not pregnant or nursing
* Patients must be deemed able to comply with the treatment plan and follow-up schedule
* Patients must provide study specific informed consent prior to study entry, including consent for mandatory tissue submission for central review
* No prior invasive malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 3 years (for example, carcinoma in situ of the breast, oral cavity, or cervix are all permissible)
* No severe, active co-morbidity, defined as follows:

* Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months
* Transmural myocardial infarction within the last 6 months
* Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration
* Chronic Obstructive Pulmonary Disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration
* Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects (coagulation parameters are not required for entry into this protocol)
* Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control (CDC) definition (HIV testing is not required for entry into this protocol)

* Protocol-specific requirements may also exclude immunocompromised patients
* Pre-existing ≥ grade 2 neuropathy
* No significant pre-existing hearing loss, as defined by the patient or treating physician

PRIOR CONCURRENT THERAPY:

* See Disease Characteristics
* No prior systemic chemotherapy or radiation therapy for salivary gland malignancy (prior chemotherapy for a different cancer is allowable)
* No prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields
* No prior organ transplant
* No concurrent hematopoietic growth factors (e.g., G-CSF or pegfilgrastim) during radiotherapy
* No concurrent erythropoiesis-stimulating agents
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Cancer Institute (NCI)

NIH

Sponsor Role collaborator

NRG Oncology

OTHER

Sponsor Role collaborator

Radiation Therapy Oncology Group

NETWORK

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Cristina P. Rodriguez, MD

Role: PRINCIPAL_INVESTIGATOR

OHSU Knight Cancer Institute

Locations

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University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, United States

Site Status

The Kirklin Clinic at Acton Road

Birmingham, Alabama, United States

Site Status

Arizona Breast Cancer Specialists-Gilbert

Gilbert, Arizona, United States

Site Status

Arizona Center for Cancer Care-Peoria

Peoria, Arizona, United States

Site Status

Cancer Center at Saint Joseph's

Phoenix, Arizona, United States

Site Status

Arizona Breast Cancer Specialists-Phoenix

Phoenix, Arizona, United States

Site Status

Arizona Oncology-Deer Valley Center

Phoenix, Arizona, United States

Site Status

Arizona Breast Cancer Specialists

Scottsdale, Arizona, United States

Site Status

Arizona Breast Cancer Specialists-Scottsdale

Scottsdale, Arizona, United States

Site Status

Arizona Oncology Services Foundation

Scottsdale, Arizona, United States

Site Status

Arizona Center for Cancer Care-Surprise

Surprise, Arizona, United States

Site Status

University of Arizona Cancer Center-Orange Grove Campus

Tucson, Arizona, United States

Site Status

Banner University Medical Center - Tucson

Tucson, Arizona, United States

Site Status

University of Arizona Cancer Center-North Campus

Tucson, Arizona, United States

Site Status

Sutter Cancer Centers Radiation Oncology Services-Auburn

Auburn, California, United States

Site Status

AIS Cancer Center at San Joaquin Community Hospital

Bakersfield, California, United States

Site Status

Mills-Peninsula Medical Center

Burlingame, California, United States

Site Status

Sutter Cancer Centers Radiation Oncology Services-Cameron Park

Cameron Park, California, United States

Site Status

Mercy San Juan Medical Center

Carmichael, California, United States

Site Status

City of Hope Comprehensive Cancer Center

Duarte, California, United States

Site Status

UC San Diego Moores Cancer Center

La Jolla, California, United States

Site Status

Los Angeles County-USC Medical Center

Los Angeles, California, United States

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USC / Norris Comprehensive Cancer Center

Los Angeles, California, United States

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Fremont - Rideout Cancer Center

Marysville, California, United States

Site Status

Memorial Medical Center

Modesto, California, United States

Site Status

Hoag Memorial Hospital

Newport Beach, California, United States

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Saint Joseph Hospital - Orange

Orange, California, United States

Site Status

Stanford Cancer Institute Palo Alto

Palo Alto, California, United States

Site Status

Sutter Cancer Centers Radiation Oncology Services-Roseville

Roseville, California, United States

Site Status

Sutter Medical Center Sacramento

Sacramento, California, United States

Site Status

University of California Davis Comprehensive Cancer Center

Sacramento, California, United States

Site Status

UCSF Medical Center-Mount Zion

San Francisco, California, United States

Site Status

UCSF Medical Center-Mission Bay

San Francisco, California, United States

Site Status

Sutter Cancer Centers Radiation Oncology Services-Vacaville

Vacaville, California, United States

Site Status

Rocky Mountain Cancer Centers-Aurora

Aurora, Colorado, United States

Site Status

University of Colorado Hospital

Aurora, Colorado, United States

Site Status

Boulder Community Hospital

Boulder, Colorado, United States

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Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, United States

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Porter Adventist Hospital

Denver, Colorado, United States

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Swedish Medical Center

Englewood, Colorado, United States

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Rocky Mountain Cancer Centers-Littleton

Littleton, Colorado, United States

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Longmont United Hospital

Longmont, Colorado, United States

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McKee Medical Center

Loveland, Colorado, United States

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North Suburban Medical Center

Thornton, Colorado, United States

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Rocky Mountain Cancer Centers-Thornton

Thornton, Colorado, United States

Site Status

William Backus Hospital

Norwich, Connecticut, United States

Site Status

Helen F Graham Cancer Center

Newark, Delaware, United States

Site Status

Christiana Care Health System-Christiana Hospital

Newark, Delaware, United States

Site Status

Beebe Health Campus

Rehoboth Beach, Delaware, United States

Site Status

UM Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables, Florida, United States

Site Status

UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, United States

Site Status

University of Florida Health Science Center - Gainesville

Gainesville, Florida, United States

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Baptist MD Anderson Cancer Center

Jacksonville, Florida, United States

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University of Florida Health Science Center - Jacksonville

Jacksonville, Florida, United States

Site Status

University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, United States

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Miami Cancer Institute

Miami, Florida, United States

Site Status

Orlando Health Cancer Institute

Orlando, Florida, United States

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Moffitt Cancer Center

Tampa, Florida, United States

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Emory Proton Therapy Center

Atlanta, Georgia, United States

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Emory University Hospital Midtown

Atlanta, Georgia, United States

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Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, United States

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Memorial Health University Medical Center

Savannah, Georgia, United States

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Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, United States

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Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, United States

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Northwestern University

Chicago, Illinois, United States

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John H Stroger Jr Hospital of Cook County

Chicago, Illinois, United States

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Loyola University Medical Center

Maywood, Illinois, United States

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Saint John's Hospital

Springfield, Illinois, United States

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IU Health North Hospital

Carmel, Indiana, United States

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Goshen Center for Cancer Care

Goshen, Indiana, United States

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Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, United States

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Sidney and Lois Eskenazi Hospital

Indianapolis, Indiana, United States

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Memorial Hospital of South Bend

South Bend, Indiana, United States

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McFarland Clinic PC - Ames

Ames, Iowa, United States

Site Status

Iowa Methodist Medical Center

Des Moines, Iowa, United States

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Mercy Medical Center - Des Moines

Des Moines, Iowa, United States

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University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, United States

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Siouxland Regional Cancer Center

Sioux City, Iowa, United States

Site Status

University of Kansas Cancer Center

Kansas City, Kansas, United States

Site Status

University of Kentucky/Markey Cancer Center

Lexington, Kentucky, United States

Site Status

The James Graham Brown Cancer Center at University of Louisville

Louisville, Kentucky, United States

Site Status

Mary Bird Perkins Cancer Center

Baton Rouge, Louisiana, United States

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University Medical Center New Orleans

New Orleans, Louisiana, United States

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Touro Infirmary

New Orleans, Louisiana, United States

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Ochsner Medical Center Jefferson

New Orleans, Louisiana, United States

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Greater Baltimore Medical Center

Baltimore, Maryland, United States

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Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, United States

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Boston Medical Center

Boston, Massachusetts, United States

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Bixby Medical Center

Adrian, Michigan, United States

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Saint Joseph Mercy Hospital

Ann Arbor, Michigan, United States

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University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, United States

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Henry Ford Cancer Institute-Downriver

Brownstown, Michigan, United States

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Henry Ford Macomb Hospital-Clinton Township

Clinton Township, Michigan, United States

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Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, United States

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Henry Ford Hospital

Detroit, Michigan, United States

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Ascension Saint John Hospital

Detroit, Michigan, United States

Site Status

Weisberg Cancer Treatment Center

Farmington Hills, Michigan, United States

Site Status

Genesys Hurley Cancer Institute

Flint, Michigan, United States

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West Michigan Cancer Center

Kalamazoo, Michigan, United States

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Saint Mary Mercy Hospital

Livonia, Michigan, United States

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Saint Joseph Mercy Oakland

Pontiac, Michigan, United States

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Lake Huron Medical Center

Port Huron, Michigan, United States

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Ascension Saint Mary's Hospital

Saginaw, Michigan, United States

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Saint John Macomb-Oakland Hospital

Warren, Michigan, United States

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Henry Ford West Bloomfield Hospital

West Bloomfield, Michigan, United States

Site Status

Mayo Clinic in Rochester

Rochester, Minnesota, United States

Site Status

University of Mississippi Medical Center

Jackson, Mississippi, United States

Site Status

Siteman Cancer Center at Saint Peters Hospital

City of Saint Peters, Missouri, United States

Site Status

University of Missouri - Ellis Fischel

Columbia, Missouri, United States

Site Status

Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, United States

Site Status

Freeman Health System

Joplin, Missouri, United States

Site Status

Delbert Day Cancer Institute at PCRMC

Rolla, Missouri, United States

Site Status

Mercy Hospital Springfield

Springfield, Missouri, United States

Site Status

SSM Health Saint Louis University Hospital

St Louis, Missouri, United States

Site Status

Washington University School of Medicine

St Louis, Missouri, United States

Site Status

Siteman Cancer Center-South County

St Louis, Missouri, United States

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Billings Clinic Cancer Center

Billings, Montana, United States

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Bozeman Deaconess Hospital

Bozeman, Montana, United States

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Kalispell Regional Medical Center

Kalispell, Montana, United States

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Nebraska Methodist Hospital

Omaha, Nebraska, United States

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Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska, United States

Site Status

Comprehensive Cancer Centers of Nevada - Henderson

Henderson, Nevada, United States

Site Status

Radiation Oncology Centers of Nevada Central

Las Vegas, Nevada, United States

Site Status

Comprehensive Cancer Centers of Nevada - Northwest

Las Vegas, Nevada, United States

Site Status

Comprehensive Cancer Centers of Nevada-Summerlin

Las Vegas, Nevada, United States

Site Status

Comprehensive Cancer Centers of Nevada

Las Vegas, Nevada, United States

Site Status

Comprehensive Cancer Centers of Nevada - Central Valley

Las Vegas, Nevada, United States

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Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, United States

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Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, United States

Site Status

Memorial Sloan Kettering Monmouth

Middletown, New Jersey, United States

Site Status

Memorial Sloan Kettering Bergen

Montvale, New Jersey, United States

Site Status

Virtua Memorial

Mount Holly, New Jersey, United States

Site Status

Rutgers New Jersey Medical School

Newark, New Jersey, United States

Site Status

Sparta Cancer Treatment Center

Sparta, New Jersey, United States

Site Status

Virtua Voorhees

Voorhees Township, New Jersey, United States

Site Status

University of New Mexico Cancer Center

Albuquerque, New Mexico, United States

Site Status

Northwell Health Imbert Cancer Center

Bay Shore, New York, United States

Site Status

Maimonides Medical Center

Brooklyn, New York, United States

Site Status

Memorial Sloan Kettering Commack

Commack, New York, United States

Site Status

Memorial Sloan Kettering Westchester

East White Plains, New York, United States

Site Status

Northwell Health/Center for Advanced Medicine

Lake Success, New York, United States

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Long Island Jewish Medical Center

New Hyde Park, New York, United States

Site Status

Mount Sinai Union Square

New York, New York, United States

Site Status

Mount Sinai Chelsea

New York, New York, United States

Site Status

Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, United States

Site Status

Lenox Hill Hospital

New York, New York, United States

Site Status

Mount Sinai Hospital

New York, New York, United States

Site Status

Memorial Sloan Kettering Cancer Center

New York, New York, United States

Site Status

Highland Hospital

Rochester, New York, United States

Site Status

University of Rochester

Rochester, New York, United States

Site Status

Memorial Sloan Kettering Sleepy Hollow

Sleepy Hollow, New York, United States

Site Status

State University of New York Upstate Medical University

Syracuse, New York, United States

Site Status

Memorial Sloan Kettering Nassau

Uniondale, New York, United States

Site Status

UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, United States

Site Status

Duke University Medical Center

Durham, North Carolina, United States

Site Status

Summa Health System - Akron Campus

Akron, Ohio, United States

Site Status

Summa Health System - Barberton Campus

Barberton, Ohio, United States

Site Status

University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, United States

Site Status

Case Western Reserve University

Cleveland, Ohio, United States

Site Status

Cleveland Clinic Foundation

Cleveland, Ohio, United States

Site Status

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, United States

Site Status

Mercy Cancer Center-Elyria

Elyria, Ohio, United States

Site Status

Summa Health Medina Medical Center

Medina, Ohio, United States

Site Status

UH Seidman Cancer Center at Lake Health Mentor Campus

Mentor, Ohio, United States

Site Status

UH Seidman Cancer Center at Southwest General Hospital

Middleburg Heights, Ohio, United States

Site Status

University Hospitals Parma Medical Center

Parma, Ohio, United States

Site Status

UH Seidman Cancer Center at Salem Regional Medical Center

Salem, Ohio, United States

Site Status

UH Seidman Cancer Center at Firelands Regional Medical Center

Sandusky, Ohio, United States

Site Status

ProMedica Flower Hospital

Sylvania, Ohio, United States

Site Status

University of Toledo

Toledo, Ohio, United States

Site Status

Mercy Health - Saint Anne Hospital

Toledo, Ohio, United States

Site Status

University of Cincinnati Cancer Center-West Chester

West Chester, Ohio, United States

Site Status

Cancer Treatment Center

Wooster, Ohio, United States

Site Status

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, United States

Site Status

Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, United States

Site Status

Clackamas Radiation Oncology Center

Clackamas, Oregon, United States

Site Status

Providence Portland Medical Center

Portland, Oregon, United States

Site Status

Providence Saint Vincent Medical Center

Portland, Oregon, United States

Site Status

Oregon Health and Science University

Portland, Oregon, United States

Site Status

Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, United States

Site Status

Bryn Mawr Hospital

Bryn Mawr, Pennsylvania, United States

Site Status

Geisinger Medical Center

Danville, Pennsylvania, United States

Site Status

UPMC Cancer Centers - Arnold Palmer Pavilion

Greensburg, Pennsylvania, United States

Site Status

UPMC Pinnacle Cancer Center/Community Osteopathic Campus

Harrisburg, Pennsylvania, United States

Site Status

Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, United States

Site Status

Geisinger Medical Oncology-Lewisburg

Lewisburg, Pennsylvania, United States

Site Status

Lewistown Hospital

Lewistown, Pennsylvania, United States

Site Status

UPMC-Coraopolis/Heritage Valley Radiation Oncology

Moon Township, Pennsylvania, United States

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UPMC Jameson

New Castle, Pennsylvania, United States

Site Status

Paoli Memorial Hospital

Paoli, Pennsylvania, United States

Site Status

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, United States

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Fox Chase Cancer Center

Philadelphia, Pennsylvania, United States

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Temple University Hospital

Philadelphia, Pennsylvania, United States

Site Status

UPMC-Saint Margaret

Pittsburgh, Pennsylvania, United States

Site Status

UPMC-Shadyside Hospital

Pittsburgh, Pennsylvania, United States

Site Status

UPMC Jefferson Regional Radiation Oncology

Pittsburgh, Pennsylvania, United States

Site Status

UPMC-Passavant Hospital

Pittsburgh, Pennsylvania, United States

Site Status

UPMC-Saint Clair Hospital Cancer Center

Pittsburgh, Pennsylvania, United States

Site Status

Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, United States

Site Status

Lankenau Medical Center

Wynnewood, Pennsylvania, United States

Site Status

Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, United States

Site Status

Medical University of South Carolina

Charleston, South Carolina, United States

Site Status

Prisma Health Cancer Institute - Faris

Greenville, South Carolina, United States

Site Status

Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, United States

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Prisma Health Cancer Institute - Greer

Greer, South Carolina, United States

Site Status

Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, United States

Site Status

Rapid City Regional Hospital

Rapid City, South Dakota, United States

Site Status

University of Tennessee - Knoxville

Knoxville, Tennessee, United States

Site Status

Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, United States

Site Status

MD Anderson in The Woodlands

Conroe, Texas, United States

Site Status

UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, United States

Site Status

M D Anderson Cancer Center

Houston, Texas, United States

Site Status

MD Anderson West Houston

Houston, Texas, United States

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MD Anderson League City

League City, Texas, United States

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MD Anderson in Sugar Land

Sugar Land, Texas, United States

Site Status

American Fork Hospital / Huntsman Intermountain Cancer Center

American Fork, Utah, United States

Site Status

Sandra L Maxwell Cancer Center

Cedar City, Utah, United States

Site Status

Logan Regional Hospital

Logan, Utah, United States

Site Status

Intermountain Medical Center

Murray, Utah, United States

Site Status

Utah Valley Regional Medical Center

Provo, Utah, United States

Site Status

Utah Cancer Specialists-Salt Lake City

Salt Lake City, Utah, United States

Site Status

Dixie Medical Center Regional Cancer Center

St. George, Utah, United States

Site Status

Norris Cotton Cancer Center-North

Saint Johnsbury, Vermont, United States

Site Status

Inova Schar Cancer Institute

Fairfax, Virginia, United States

Site Status

Inova Fairfax Hospital

Falls Church, Virginia, United States

Site Status

Sentara Cancer Institute at Sentara CarePlex Hospital

Hampton, Virginia, United States

Site Status

Sentara Norfolk General Hospital

Norfolk, Virginia, United States

Site Status

Sentara Virginia Beach General Hospital

Virginia Beach, Virginia, United States

Site Status

Saint Francis Hospital

Federal Way, Washington, United States

Site Status

Seattle Cancer Care Alliance at Northwest Hospital

Seattle, Washington, United States

Site Status

University of Washington Medical Center - Montlake

Seattle, Washington, United States

Site Status

PeaceHealth Southwest Medical Center

Vancouver, Washington, United States

Site Status

Compass Oncology Vancouver

Vancouver, Washington, United States

Site Status

West Virginia University Healthcare

Morgantown, West Virginia, United States

Site Status

Wheeling Hospital/Schiffler Cancer Center

Wheeling, West Virginia, United States

Site Status

Aurora Cancer Care-Southern Lakes VLCC

Burlington, Wisconsin, United States

Site Status

Aurora Health Center-Fond du Lac

Fond du Lac, Wisconsin, United States

Site Status

Aurora Health Care Germantown Health Center

Germantown, Wisconsin, United States

Site Status

Aurora Cancer Care-Grafton

Grafton, Wisconsin, United States

Site Status

Green Bay Oncology at Saint Vincent Hospital

Green Bay, Wisconsin, United States

Site Status

Saint Vincent Hospital Cancer Center Green Bay

Green Bay, Wisconsin, United States

Site Status

Saint Vincent Hospital Cancer Center at Saint Mary's

Green Bay, Wisconsin, United States

Site Status

Aurora BayCare Medical Center

Green Bay, Wisconsin, United States

Site Status

Aurora Cancer Care-Kenosha South

Kenosha, Wisconsin, United States

Site Status

University of Wisconsin Hospital and Clinics

Madison, Wisconsin, United States

Site Status

Aurora Bay Area Medical Group-Marinette

Marinette, Wisconsin, United States

Site Status

Bay Area Medical Center

Marinette, Wisconsin, United States

Site Status

Aurora Cancer Care-Milwaukee

Milwaukee, Wisconsin, United States

Site Status

Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, United States

Site Status

Medical College of Wisconsin

Milwaukee, Wisconsin, United States

Site Status

Vince Lombardi Cancer Clinic - Oshkosh

Oshkosh, Wisconsin, United States

Site Status

Aurora Cancer Care-Racine

Racine, Wisconsin, United States

Site Status

Vince Lombardi Cancer Clinic-Sheboygan

Sheboygan, Wisconsin, United States

Site Status

Saint Vincent Hospital Cancer Center at Sturgeon Bay

Sturgeon Bay, Wisconsin, United States

Site Status

Aurora Medical Center in Summit

Summit, Wisconsin, United States

Site Status

Vince Lombardi Cancer Clinic-Two Rivers

Two Rivers, Wisconsin, United States

Site Status

Aurora Cancer Care-Milwaukee West

Wauwatosa, Wisconsin, United States

Site Status

Aurora West Allis Medical Center

West Allis, Wisconsin, United States

Site Status

Aspirus Cancer Care - Wisconsin Rapids

Wisconsin Rapids, Wisconsin, United States

Site Status

Cross Cancer Institute

Edmonton, Alberta, Canada

Site Status

Health Sciences North

Greater Sudbury, Ontario, Canada

Site Status

London Regional Cancer Program

London, Ontario, Canada

Site Status

University Health Network-Princess Margaret Hospital

Toronto, Ontario, Canada

Site Status

CHUM - Hopital Notre-Dame

Montreal, Quebec, Canada

Site Status

McGill University Department of Oncology

Montreal, Quebec, Canada

Site Status

CHUM - Centre Hospitalier de l'Universite de Montreal

Montreal, Quebec, Canada

Site Status

The Research Institute of the McGill University Health Centre (MUHC)

Montreal, Quebec, Canada

Site Status

King Faisal Specialist Hospital and Research Centre

Riyadh, , Saudi Arabia

Site Status

Countries

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United States Canada Saudi Arabia

References

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Joshi NP, Broughman JR. Postoperative Management of Salivary Gland Tumors. Curr Treat Options Oncol. 2021 Feb 9;22(3):23. doi: 10.1007/s11864-021-00820-9.

Reference Type DERIVED
PMID: 33560478 (View on PubMed)

Other Identifiers

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CDR0000686072

Identifier Type: -

Identifier Source: secondary_id

NCI-2013-00370

Identifier Type: -

Identifier Source: secondary_id

RTOG-1008

Identifier Type: -

Identifier Source: org_study_id

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