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Changes in Liver Function After Stereotactic Body Radiation Therapy Measured by PET/CT

NCT ID: NCT01213758

Last Updated: 2017-10-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

14 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-06-30

Study Completion Date

2016-04-30

Brief Summary

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Patients treated with stereotactic radiotherapy for liver tumors undergo PET/CT using the galactose analogue 18-F-deoxy-galactose (FDGal) before and after radiotherapy. This technique provides volumetric mapping of liver function and it allows quantisation of liver function. The method may be used for selection of patients for stereotactic radiotherapy of liver tumors, for determination of radiation induced liver dysfunction and may be included into the treatment planning process of stereotactic radiotherapy.

Detailed Description

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Conditions

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Hepatocellular Carcinoma Cholangiocarcinoma Metastases Stereotactic Body Radiotherapy

Keywords

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liver function galactose 18-F-deoxy-galactose PET/CT stereotactic body radiation therapy SBRT

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Liver tumors

Patients where stereotactic body radiation therapy is planned for primary or metastatic liver tumors.

Measuring liver function by PET/CT

Intervention Type OTHER

Measuring liver function by use of FDGal and PET/CT before, 1 month and 3 months after stereotactic radiotherapy for liver tumors

Interventions

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Measuring liver function by PET/CT

Measuring liver function by use of FDGal and PET/CT before, 1 month and 3 months after stereotactic radiotherapy for liver tumors

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* liver tumor
* referred for stereotactic radiation therapy
* age \> 18 years

Exclusion Criteria

* Impaired kidney function
* Pregnancy
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Danish Cancer Society

OTHER

Sponsor Role collaborator

University of Aarhus

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Morten Høyer, MD PhD

Role: PRINCIPAL_INVESTIGATOR

Aarhus University Hospital

Locations

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Aarhus University Hospital

Aarhus C, , Denmark

Site Status

Countries

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Denmark

Related Links

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http://www.cirro.dk

The Lundbeck Foundation Centre for Interventional Research in Radiation Oncology

Other Identifiers

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AarhusLiverRadGal

Identifier Type: -

Identifier Source: org_study_id