Impact of Intensive Exercise Training on Coronary Collateral Circulation in Patients With Stable CAD
NCT ID: NCT01209637
Last Updated: 2016-10-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
60 participants
INTERVENTIONAL
2010-03-31
2012-12-31
Brief Summary
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There are some hinds for improved collateral circulation after exercise training, nevertheless there is no study showing significant improvement/ increase in coronary collaterals. This might be due to technique of collateral measurement. Therefore we conduct a study were coronary blod flow before and after 4 weeks of exercise training were measured.
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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control
standard care of coronary artery diseases incl. recommended home based exercise 3x/week
No interventions assigned to this group
Exercise training
exercise training for 4 weeks at 70% of ischemia free individual threshold within a rehabilitation care center
exercise training
exercise training min. 4 times a day for at least 30 min
intensive exercise training
intensive exercise training incl. interval training
Intensive exercise training
Intensive exercise training for 4 times / day incl. interval training at 95% individual threshold
Interventions
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exercise training
exercise training min. 4 times a day for at least 30 min
Intensive exercise training
Intensive exercise training for 4 times / day incl. interval training at 95% individual threshold
Eligibility Criteria
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Inclusion Criteria
* min.1 coronary artery stenosis \>50%
* patient is symptomatic ( CCS 1-3)or has documented myocardial ischemia during stress test
* angina threshold \>75 Watt
* informed consent
Exclusion Criteria
* akut coronary syndrome within 2 weeks
* LV-EF \< 40 %
* significant valve diseases
* reduced patient compliance
* muscular disorder
* bronchial asthma or COLD stadium III and IV
18 Years
75 Years
ALL
No
Sponsors
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University of Leipzig
OTHER
Responsible Party
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Sven Möbius-Winkler
PI
Principal Investigators
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Sven Möbius-Winkler, MD
Role: PRINCIPAL_INVESTIGATOR
Heart Center Leipzig- University Leipzig
Locations
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Heart Center Leipzig- University Leipzig
Leipzig, , Germany
Countries
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References
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Mobius-Winkler S, Uhlemann M, Adams V, Sandri M, Erbs S, Lenk K, Mangner N, Mueller U, Adam J, Grunze M, Brunner S, Hilberg T, Mende M, Linke AP, Schuler G. Coronary Collateral Growth Induced by Physical Exercise: Results of the Impact of Intensive Exercise Training on Coronary Collateral Circulation in Patients With Stable Coronary Artery Disease (EXCITE) Trial. Circulation. 2016 Apr 12;133(15):1438-48; discussion 1448. doi: 10.1161/CIRCULATIONAHA.115.016442. Epub 2016 Mar 15.
Uhlemann M, Adams V, Lenk K, Linke A, Erbs S, Adam J, Thiele H, Hilberg T, Gutberlet M, Grunze M, Schuler GC, Mobius-Winkler S. Impact of different exercise training modalities on the coronary collateral circulation and plaque composition in patients with significant coronary artery disease (EXCITE trial): study protocol for a randomized controlled trial. Trials. 2012 Sep 14;13:167. doi: 10.1186/1745-6215-13-167.
Other Identifiers
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SMW 04
Identifier Type: -
Identifier Source: org_study_id