Acoustic Liver Biopsy in Normals and in Patients With Cirrhosis Using Endoscopic Ultrasound

NCT ID: NCT01208311

Last Updated: 2016-12-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

7 participants

Study Classification

OBSERVATIONAL

Study Start Date

2004-12-31

Study Completion Date

2016-12-31

Brief Summary

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The purpose of this study is to determine the amount of fibrosis in the liver of hepatitis C patients with advanced fibrosis, using endoscopic ultrasound.

Detailed Description

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Background: Transabdominal ultrasound cannot be used to quantitate fibrosis in patients with cirrhosis due to variability in the abdominal wall thickness and composition. This variability can be eliminated by using endoscopic ultrasound.

Aim: To determine the amount of fibrosis in the liver of hepatitis C patients with advanced fibrosis, using endoscopic ultrasound.

Conditions

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Alcoholism Cirrhosis Hepatitis c

Keywords

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Alcoholic cirrhosis hepatitis c cirrhosis cirrhosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients with Hepatitis C Cirrhosis

Patients with Hepatitis C Cirrhosis

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* hepatic cirrhosis and hepatitis C and undergoing endoscopy
* Alcoholic liver and undergoing endoscopy
* Normal liver undergoing endoscopy

Exclusion Criteria

* pregnancy
* Children
Minimum Eligible Age

20 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Northwell Health

OTHER

Sponsor Role lead

Responsible Party

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Larry Miller

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Larry S Miller, M.D

Role: PRINCIPAL_INVESTIGATOR

Northwell Health

Locations

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LIJ Medical Center- NSLIJ Health System

New Hyde Park, New York, United States

Site Status

Countries

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United States

References

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Brown JJ, Naylor MJ, Yagan N. Imaging of hepatic cirrhosis. Radiology. 1997 Jan;202(1):1-16. doi: 10.1148/radiology.202.1.8988182. No abstract available.

Reference Type BACKGROUND
PMID: 8988182 (View on PubMed)

Mergo PJ, Ros PR. Imaging of diffuse liver disease. Radiol Clin North Am. 1998 Mar;36(2):365-75. doi: 10.1016/s0033-8389(05)70028-2.

Reference Type BACKGROUND
PMID: 9520988 (View on PubMed)

Taylor HM, Ros PR. Hepatic imaging. An overview. Radiol Clin North Am. 1998 Mar;36(2):237-45. doi: 10.1016/s0033-8389(05)70019-1.

Reference Type BACKGROUND
PMID: 9520979 (View on PubMed)

Zwiebel WJ. Sonographic diagnosis of diffuse liver disease. Semin Ultrasound CT MR. 1995 Feb;16(1):8-15. doi: 10.1016/0887-2171(95)90011-x.

Reference Type BACKGROUND
PMID: 7718284 (View on PubMed)

Aube C, Oberti F, Korali N, Namour MA, Loisel D, Tanguy JY, Valsesia E, Pilette C, Rousselet MC, Bedossa P, Rifflet H, Maiga MY, Penneau-Fontbonne D, Caron C, Cales P. Ultrasonographic diagnosis of hepatic fibrosis or cirrhosis. J Hepatol. 1999 Mar;30(3):472-8. doi: 10.1016/s0168-8278(99)80107-x.

Reference Type BACKGROUND
PMID: 10190731 (View on PubMed)

Harbin WP, Robert NJ, Ferrucci JT Jr. Diagnosis of cirrhosis based on regional changes in hepatic morphology: a radiological and pathological analysis. Radiology. 1980 May;135(2):273-83. doi: 10.1148/radiology.135.2.7367613.

Reference Type BACKGROUND
PMID: 7367613 (View on PubMed)

Hirata M, Akbar SM, Horiike N, Onji M. Noninvasive diagnosis of the degree of hepatic fibrosis using ultrasonography in patients with chronic liver disease due to hepatitis C virus. Eur J Clin Invest. 2001 Jun;31(6):528-35. doi: 10.1046/j.1365-2362.2001.00840.x.

Reference Type BACKGROUND
PMID: 11422403 (View on PubMed)

Hultcrantz R, Gabrielsson N. Patients with persistent elevation of aminotransferases: investigation with ultrasonography, radionuclide imaging and liver biopsy. J Intern Med. 1993 Jan;233(1):7-12. doi: 10.1111/j.1365-2796.1993.tb00640.x.

Reference Type BACKGROUND
PMID: 8429291 (View on PubMed)

Zheng RQ, Wang QH, Lu MD, Xie SB, Ren J, Su ZZ, Cai YK, Yao JL. Liver fibrosis in chronic viral hepatitis: an ultrasonographic study. World J Gastroenterol. 2003 Nov;9(11):2484-9. doi: 10.3748/wjg.v9.i11.2484.

Reference Type BACKGROUND
PMID: 14606081 (View on PubMed)

Andanappa HK, Dai Q, Korimilli A, Panganamamula K, Friedenberg F, Miller L. Acoustic liver biopsy using endoscopic ultrasound. Dig Dis Sci. 2008 Apr;53(4):1078-83. doi: 10.1007/s10620-008-0211-4. Epub 2008 Feb 13.

Reference Type RESULT
PMID: 18270828 (View on PubMed)

Other Identifiers

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4539

Identifier Type: -

Identifier Source: org_study_id