Mediators of Atherosclerosis in South Asians Living in America

NCT ID: NCT01207167

Last Updated: 2025-03-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

2314 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-09-30

Study Completion Date

2025-12-31

Brief Summary

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South Asian (Indian, Pakistani, Bangladeshi, Nepali, and Sri Lankan) individuals have high rates of cardiovascular disease that is not explained by traditional cardiovascular risk factors. Though South Asians represent over one-quarter of the world's population, there are no longitudinal studies in this high-risk ethnic group. The investigators aim to establish a longitudinal study of South Asians at three United States centers to identify risk factors linked to subclinical atherosclerosis and incident cardiovascular disease. The purpose of this study is to understand the causes of heart disease and stroke in South Asians and compare these causes to those in other United States ethnic groups.

Detailed Description

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Conditions

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Atherosclerosis Cardiovascular Diseases Heart Diseases Coronary Artery Disease Coronary Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* South Asian ancestry defined by having at least 3 grandparents born in one of the following countries: India, Pakistan, Bangladesh, Nepal, or Sri Lanka
* age between 40 and 84 years.

Exclusion Criteria

* Physician diagnosed heart attack, stroke or transient ischemic attack (TIA), heart failure, or angina (or use of nitroglycerin)
* Current atrial fibrillation
* Past history of cardiovascular procedures (coronary artery bypass graft (CABG) Surgery, angioplasty, valve replacement, pacemaker or defibrillator implantation, or any surgery on the heart or arteries)
* Active treatment for cancer
* Life expectancy less than 5 years due to serious medical illness
* Impaired cognitive ability as judged by the reviewer
* Plans to move out of the study region in next 5 years
* Weight greater than 300 pounds
* Living in a nursing home or on a waiting list
* Unable to speak/read/write English, Hindi, Urdu, or Bangla
Minimum Eligible Age

40 Years

Maximum Eligible Age

84 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Northwestern University

OTHER

Sponsor Role collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

Sponsor Role collaborator

National Institute on Minority Health and Health Disparities (NIMHD)

NIH

Sponsor Role collaborator

New York University

OTHER

Sponsor Role collaborator

University of California, San Francisco

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Alka Kanaya, MD

Role: PRINCIPAL_INVESTIGATOR

University of California, San Francisco

Namratha Kandula, MD

Role: PRINCIPAL_INVESTIGATOR

Northwestern University

Nadia Islam, PhD

Role: PRINCIPAL_INVESTIGATOR

New York University

Locations

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University of California, San Francisco

San Francisco, California, United States

Site Status ACTIVE_NOT_RECRUITING

Northwestern University

Chicago, Illinois, United States

Site Status RECRUITING

New York University

New York, New York, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Alka Kanaya, MD

Role: CONTACT

Ann Chang

Role: CONTACT

Facility Contacts

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Meredith Rathert

Role: primary

Shahmir Ali

Role: primary

Other Identifiers

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R01HL093009

Identifier Type: NIH

Identifier Source: secondary_id

View Link

R01MD016071

Identifier Type: NIH

Identifier Source: secondary_id

View Link

R01HL149809

Identifier Type: NIH

Identifier Source: secondary_id

View Link

MASALA

Identifier Type: -

Identifier Source: org_study_id

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