A COMparison Between PAClitaxel-coated Balloon and pacliTaxel-eluting Stent in the Treatment of In-Stent Restenosis (COMPACT-ISR)

NCT ID: NCT01204320

Last Updated: 2010-09-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE4

Total Enrollment

154 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-01-31

Brief Summary

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This is a multicentric randomized comparison between paclitaxel-coated balloon angioplasty or paclitaxel-eluting stent implantation in patients with stable or unstable angina with the evaluation of restenosis by Quantitative Coronary Analysis.

Detailed Description

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The purpose of this study is to determine the late luminal loss by Quantitative Coronary Analysis at 6 month-follow up after paclitaxel-coated balloon angioplasty or paclitaxel-eluting stent implantation in the treatment of in-stent restenosis.

Conditions

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Stable Angina Unstable Angina

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Paclitaxel-coated Balloon

Paclitaxel-coated Balloon Angioplasty

Group Type EXPERIMENTAL

Paclitaxel-coated Balloon

Intervention Type PROCEDURE

POBA

Paclitaxel-eluting Stent

Paclitaxel-eluting Stent Implantation

Group Type ACTIVE_COMPARATOR

Paclitaxel-eluting Stent

Intervention Type DEVICE

Stenting

Interventions

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Paclitaxel-coated Balloon

POBA

Intervention Type PROCEDURE

Paclitaxel-eluting Stent

Stenting

Intervention Type DEVICE

Other Intervention Names

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Orbus Taxus

Eligibility Criteria

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Inclusion Criteria

* informed consent
* \>18y
* Stable Angina or Unstable Angina
* Single restenotic lesion in a previously stented coronary artery

Exclusion Criteria

* Acute Myocardial Infarction within 72h
* Serum Creatinine\>2.0 mg/dL
* Contraindications to ASA, Heparin, Clopidogrel, Ticlopidine, Abciximab, Tirofiban, Paclitaxel
* Contraindications to contrast media
* Life expectancy \< 2y
* Target Lesion length \> 30mm
* Target Lesion diameter \<= 2.5 mm
* Target stenosis \< 70%
* Massive Calcifications in the target segment
* Evidence of intra-coronary thrombus
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ospedale San Donato

OTHER

Sponsor Role lead

Responsible Party

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Ospedale SanDonato

Principal Investigators

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Leonardo Bolognese, MD

Role: STUDY_CHAIR

Cardiovascular Department - San Donato Hospital

Locations

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San Donato Hospital

Arezzo, AR, Italy

Site Status

Countries

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Italy

Other Identifiers

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Arezzo003

Identifier Type: -

Identifier Source: org_study_id