Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH)
NCT ID: NCT01202864
Last Updated: 2017-09-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
6000 participants
OBSERVATIONAL
2010-08-01
2017-08-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
OTHER
Study Groups
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Cases
3000 Cases
No interventions assigned to this group
Controls
3000 Controls
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
1. Age 18 years or greater, fulfillment of the criteria for intracerebral hemorrhage
2. Resident for at least 6 months within 50 miles of the recruiting center
3. No evidence of trauma, vascular malformation or aneurysm, or brain tumor as a cause of the hemorrhage
4. Ability of the patient or legal representative to provide informed consent
Exclusion Criteria
2. Hemorrhagic transformation of ischemic infarct
3. Hemorrhage secondary to dural venous sinus thrombosis
18 Years
ALL
No
Sponsors
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Massachusetts General Hospital
OTHER
Columbia University
OTHER
University of Maryland
OTHER
Georgetown University
OTHER
Wake Forest University
OTHER
Emory University
OTHER
University of Miami
OTHER
University of Illinois at Chicago
OTHER
University of Texas, Southwestern Medical Center at Dallas
OTHER
The University of Texas Health Science Center, Houston
OTHER
The University of Texas Health Science Center at San Antonio
OTHER
University of New Mexico
OTHER
University of Arizona
OTHER
University of Southern California
OTHER
St. Luke's-Roosevelt Hospital Center
OTHER
University of California, San Francisco
OTHER
Duke University
OTHER
University of Virginia
OTHER
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
University of Cincinnati
OTHER
Responsible Party
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Daniel Woo
Professor
Principal Investigators
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Daniel Woo, MD, MS
Role: PRINCIPAL_INVESTIGATOR
University of Cincinnati
Matthew Flaherty, MD
Role: PRINCIPAL_INVESTIGATOR
University of Cincinnati
Locations
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University of Arizona
Tucson, Arizona, United States
University of Southern California
Los Angeles, California, United States
Georgetown University
Washington D.C., District of Columbia, United States
University of Miami - Biorepository
Miami, Florida, United States
University of Miami
Miami, Florida, United States
Emory University
Atlanta, Georgia, United States
University of Illinois
Chicago, Illinois, United States
University of Maryland
Baltimore, Maryland, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
University of New Mexico
Albuquerque, New Mexico, United States
Columbia University
New York, New York, United States
Wake Forest University
Winston-Salem, North Carolina, United States
University of Texas Southwestern Medical Center at Dallas
Dallas, Texas, United States
University of Texas Medical School at Houston
Houston, Texas, United States
University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States
Countries
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References
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Taylor TN, Davis PH, Torner JC, Holmes J, Meyer JW, Jacobson MF. Lifetime cost of stroke in the United States. Stroke. 1996 Sep;27(9):1459-66. doi: 10.1161/01.str.27.9.1459.
Woo D, Sauerbeck LR, Kissela BM, Khoury JC, Szaflarski JP, Gebel J, Shukla R, Pancioli AM, Jauch EC, Menon AG, Deka R, Carrozzella JA, Moomaw CJ, Fontaine RN, Broderick JP. Genetic and environmental risk factors for intracerebral hemorrhage: preliminary results of a population-based study. Stroke. 2002 May;33(5):1190-5. doi: 10.1161/01.str.0000014774.88027.22.
Kissela B, Schneider A, Kleindorfer D, Khoury J, Miller R, Alwell K, Woo D, Szaflarski J, Gebel J, Moomaw C, Pancioli A, Jauch E, Shukla R, Broderick J. Stroke in a biracial population: the excess burden of stroke among blacks. Stroke. 2004 Feb;35(2):426-31. doi: 10.1161/01.STR.0000110982.74967.39.
Hardie K, Hankey GJ, Jamrozik K, Broadhurst RJ, Anderson C. Ten-year survival after first-ever stroke in the perth community stroke study. Stroke. 2003 Aug;34(8):1842-6. doi: 10.1161/01.STR.0000082382.42061.EE. Epub 2003 Jul 3.
Broderick JP, Phillips SJ, Whisnant JP, O'Fallon WM, Bergstralh EJ. Incidence rates of stroke in the eighties: the end of the decline in stroke? Stroke. 1989 May;20(5):577-82. doi: 10.1161/01.str.20.5.577.
Broderick JP, Brott T, Tomsick T, Miller R, Huster G. Intracerebral hemorrhage more than twice as common as subarachnoid hemorrhage. J Neurosurg. 1993 Feb;78(2):188-91. doi: 10.3171/jns.1993.78.2.0188.
Barber M, Stott DJ. Validity of the Telephone Interview for Cognitive Status (TICS) in post-stroke subjects. Int J Geriatr Psychiatry. 2004 Jan;19(1):75-9. doi: 10.1002/gps.1041.
de Jager CA, Budge MM, Clarke R. Utility of TICS-M for the assessment of cognitive function in older adults. Int J Geriatr Psychiatry. 2003 Apr;18(4):318-24. doi: 10.1002/gps.830.
MAHONEY FI, BARTHEL DW. FUNCTIONAL EVALUATION: THE BARTHEL INDEX. Md State Med J. 1965 Feb;14:61-5. No abstract available.
RANKIN J. Cerebral vascular accidents in patients over the age of 60. II. Prognosis. Scott Med J. 1957 May;2(5):200-15. doi: 10.1177/003693305700200504. No abstract available.
Flibotte JJ, Hagan N, O'Donnell J, Greenberg SM, Rosand J. Warfarin, hematoma expansion, and outcome of intracerebral hemorrhage. Neurology. 2004 Sep 28;63(6):1059-64. doi: 10.1212/01.wnl.0000138428.40673.83.
Goldstein JN, Fazen LE, Snider R, Schwab K, Greenberg SM, Smith EE, Lev MH, Rosand J. Contrast extravasation on CT angiography predicts hematoma expansion in intracerebral hemorrhage. Neurology. 2007 Mar 20;68(12):889-94. doi: 10.1212/01.wnl.0000257087.22852.21.
Kumar MA, Rost NS, Snider RW, Chanderraj R, Greenberg SM, Smith EE, Rosand J. Anemia and hematoma volume in acute intracerebral hemorrhage. Crit Care Med. 2009 Apr;37(4):1442-7. doi: 10.1097/CCM.0b013e31819ced3a.
Brott T, Broderick J, Kothari R, Barsan W, Tomsick T, Sauerbeck L, Spilker J, Duldner J, Khoury J. Early hemorrhage growth in patients with intracerebral hemorrhage. Stroke. 1997 Jan;28(1):1-5. doi: 10.1161/01.str.28.1.1.
Davis SM, Broderick J, Hennerici M, Brun NC, Diringer MN, Mayer SA, Begtrup K, Steiner T; Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators. Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage. Neurology. 2006 Apr 25;66(8):1175-81. doi: 10.1212/01.wnl.0000208408.98482.99.
Mayer SA, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN, Skolnick BE, Steiner T; FAST Trial Investigators. Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med. 2008 May 15;358(20):2127-37. doi: 10.1056/NEJMoa0707534.
Behymer TP, Sekar P, Demel SL, Aziz YN, Coleman ER, Williamson BJ, Stanton RJ, Sawyer RP, Turner AC, Vagal VS, Osborne J, Gilkerson LA, Comeau ME, Flaherty ML, Langefeld CD, Woo D. Psychosocial Stress and Risk for Intracerebral Hemorrhage in the ERICH (Ethnic/Racial Variations of Intracerebral Hemorrhage) Study. J Am Heart Assoc. 2025 Mar 18;14(6):e024457. doi: 10.1161/JAHA.121.024457. Epub 2025 Mar 7.
Ridha M, Hannawi Y, Murthy S, Carvalho Poyraz F, Kumar A, Park S, Roh D, Sekar P, Woo D, Burke J. Premorbid Blood Pressure Control Modifies Risk of DWI Lesions With Acute Blood Pressure Reduction in Intracerebral Hemorrhage. Hypertension. 2024 Oct;81(10):2113-2123. doi: 10.1161/HYPERTENSIONAHA.124.23271. Epub 2024 Jul 29.
Ng Y, Qi W, King NKK, Christianson T, Krishnamoorthy V, Shah S, Divani A, Bettin M, Coleman ER, Flaherty ML, Walsh KB, Testai FD, McCauley JL, Gilkerson LA, Langefeld CD, Behymer TP, Woo D, James ML. Initial antihypertensive agent effects on acute blood pressure after intracerebral haemorrhage. Stroke Vasc Neurol. 2022 Oct;7(5):367-374. doi: 10.1136/svn-2021-001101. Epub 2022 Apr 20.
Liu L, Fuller M, Behymer TP, Ng Y, Christianson T, Shah S, King NKK, Woo D, James ML. Selective Serotonin Reuptake Inhibitors and Intracerebral Hemorrhage Risk and Outcome. Stroke. 2020 Apr;51(4):1135-1141. doi: 10.1161/STROKEAHA.119.028406. Epub 2020 Mar 4.
James ML, Langefeld CD, Sekar P, Moomaw CJ, Elkind MSV, Worrall BB, Sheth KN, Martini SR, Osborne J, Woo D; ERICH Investigators. Assessment of the interaction of age and sex on 90-day outcome after intracerebral hemorrhage. Neurology. 2017 Sep 5;89(10):1011-1019. doi: 10.1212/WNL.0000000000004255. Epub 2017 Jul 14.
Walsh KB, Woo D, Sekar P, Osborne J, Moomaw CJ, Langefeld CD, Adeoye O. Untreated Hypertension: A Powerful Risk Factor for Lobar and Nonlobar Intracerebral Hemorrhage in Whites, Blacks, and Hispanics. Circulation. 2016 Nov 8;134(19):1444-1452. doi: 10.1161/CIRCULATIONAHA.116.024073. Epub 2016 Oct 13.
Other Identifiers
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R01NS069763-01
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
1008059
Identifier Type: -
Identifier Source: org_study_id
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