Colorectal Cancer Umbrella Protocol - Assessment of Targeted Therapies Against Colorectal Cancer (ATTACC Program) Screening Protocol
NCT ID: NCT01196130
Last Updated: 2022-12-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
1275 participants
OBSERVATIONAL
2010-08-31
2022-12-09
Brief Summary
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This is an investigational study. This study's biomarker testing is for research purposes only.
Up to 1280 patients will be enrolled in this study. All will be enrolled at MD Anderson.
Detailed Description
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Study Participation:
If you agree to take part in this study, the following tests and procedures will be performed:
* A leftover sample of tumor tissue from a previous procedure, if available, will be used for biomarker testing.
* Blood (about 3 tablespoons) will be drawn for biomarker testing, to check for levels of cytokines (proteins that may affect the immune system), and to check the circulating tumor cells (CTCs) in your blood.
* You will be asked how well you are able to perform the normal activities of daily living (performance status).
You will also fill out a questionnaire about the cancer symptoms. This should take about 5 minutes.
Biomarker Test Results:
The study doctor and staff will review the biomarker test results with you.
If the results seem to show that a certain investigational drug may help to control the cancer, and the drug is available through a separate MD Anderson clinical research study called a "companion" drug study, your doctor may recommend that you have additional tests and procedures performed. The tests and procedures will be performed as part of the companion drug study to see if you are eligible to receive that drug. You will be asked to sign a separate consent form for the companion drug study.
It is possible that the biomarker test results may seem to show that more than one drug may help to control the cancer. If so, it may be possible that you could receive the other drug(s) under other companion studies in the future. The study tests described below would be repeated during those other studies as well.
Even if the biomarker testing shows that a certain drug may be helpful, it is possible that you may not be eligible to take part in the separate companion drug study, the study drug may not be available, or there may be other reasons you cannot take part in the drug study. You may also decide that you do not want to take part in the companion drug study. Your doctor will discuss other available treatment options with you.
Study Visits:
At study visits for this biomarker research study, the following tests and procedures will be performed:
* You will fill out the cancer symptom questionnaire.
* Your performance status will be recorded.
* Blood (about 1 tablespoon) will be drawn for biomarker, cytokine, and CTC testing.
Your schedule of study visits will depend on whether or not you take part in a companion study. There is a different schedule of visits for participants who do not take part in a companion study but instead either take part in a clinical research study that is not a companion study or they receive standard cancer drug(s).
If you take part in 1 or more companion studies, you will have study visits for this biomarker research study on the following schedule:
* before you start taking the drug(s) if you join a companion drug study and it has been 2 or more weeks since you had these tests done (note: the amount of blood drawn will be about 2 tablespoons at this visit)
* each time you return for imaging scans during the time that you take part in 1 or more companion drug studies
* after you stop taking part in a companion drug study
If your first treatment after consenting to this biomarker research study is part of a clinical research study that is not a companion study or if you receive standard cancer drug(s), you will have study visits for this biomarker research study on the following schedule:
* before you start taking the drug(s) during your first treatment period at MD Anderson and it has been 2 or more weeks since you had these tests done (note: the amount of blood drawn will be about 2 tablespoons at this visit)
* each time you return for imaging scans during your first treatment period at MD Anderson
* after you first stop taking part in a clinical research study that is not a companion drug study, or until you first stop taking standard cancer drug(s).
Length of Treatment:
The study testing will continue:
* for as long as you are taking part in a companion drug study, or
* until you first stop taking part in a clinical research study that is not a companion drug study, or until you first stop taking standard cancer drug(s), if you do not take part in a companion drug study.
Follow-Up Visit:
If you stop taking part in this study:
* You will fill out the cancer symptom questionnaire.
* Your performance status will be recorded.
* Blood (about 1 tablespoon) will be drawn for biomarker, cytokine, and CTC testing.
Long-Term Follow-Up:
After your follow-up visit, from then on, the research staff will collect information on your health status, the drug(s) you receive, and the status of the disease. This information may be collected at the time of standard clinic visits, by reviewing your medical record and imaging scans, and/or by contacting you by phone, mail, and/or email. If you are called, the call will last about 10 minutes or less.
Conditions
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Keywords
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Study Design
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CASE_ONLY
PROSPECTIVE
Study Groups
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Biomarker Assessment
Leftover sample of tumor tissue from a previous procedure used for biomarker testing. Blood drawn for biomarker testing, to check for levels of cytokines, and to check the circulating tumor cells (CTCs). Cancer Symptom Questionnaire completion about cancer symptoms.
Cancer Symptom Questionnaire
5 minute questionnaire(s) completed at each study visit.
Biomarker Testing
Blood draw at each study visit for biomarker and cytokine testing.
Interventions
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Cancer Symptom Questionnaire
5 minute questionnaire(s) completed at each study visit.
Biomarker Testing
Blood draw at each study visit for biomarker and cytokine testing.
Eligibility Criteria
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Inclusion Criteria
2. The patient must have been previously treated with systemic chemotherapy for metastatic or unresectable, locally advanced colorectal cancer, with no limit on the number of prior regimens. Patients who develop recurrent or metastatic disease on or within 6 months of adjuvant therapy are eligible.
3. Age \>/=18 years to provide a uniform oncologic phenotype of adult-onset colorectal cancer.
4. ECOG performance status 0-2.
5. The patient has signed informed consent.
Exclusion Criteria
18 Years
ALL
No
Sponsors
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National Cancer Institute (NCI)
NIH
M.D. Anderson Cancer Center
OTHER
Responsible Party
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Principal Investigators
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Scott Kopetz, MD
Role: PRINCIPAL_INVESTIGATOR
M.D. Anderson Cancer Center
Locations
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University of Texas MD Anderson Cancer Center
Houston, Texas, United States
Countries
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References
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Overman MJ, Morris V, Kee B, Fogelman D, Xiao L, Eng C, Dasari A, Shroff R, Mazard T, Shaw K, Vilar E, Raghav K, Shureiqi I, Liang L, Mills GB, Wolff RA, Hamilton S, Meric-Bernstam F, Abbruzzese J, Morris J, Maru D, Kopetz S. Utility of a molecular prescreening program in advanced colorectal cancer for enrollment on biomarker-selected clinical trials. Ann Oncol. 2016 Jun;27(6):1068-1074. doi: 10.1093/annonc/mdw073. Epub 2016 Feb 18.
Related Links
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University of Texas MD Anderson Cancer Center Website
Other Identifiers
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RP110584
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
NCI-2017-00505
Identifier Type: REGISTRY
Identifier Source: secondary_id
2009-0091
Identifier Type: -
Identifier Source: org_study_id