Pemetrexed in Advanced Non-small Cell Lung Cancer

NCT ID: NCT01193959

Last Updated: 2022-09-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

33 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-09-30

Study Completion Date

2012-06-30

Brief Summary

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Present study is aimed at investigating potential molecular predictors of sensitivity or resistance to single-agent pemetrexed in the ≥ second line setting in a large cohort of advanced non-small cell lung cancer (NSCLC) patients. The following biomarkers will be investigated with either immunohistochemistry, fluorescence in situ hybridization or genotyping: thymidylate synthase (TS), dihydrofolate reductase (DHFR), glycinamide ribonucleotide formyl transferase (GARFT), aminoimidazole carboxamide ribonucleotide formyltransferase (ATIC/AICARFT), epidermal growth factor receptor (EGFR), Kirsten rat sarcoma 2 viral oncogene homolog (KRAS), v-myc myelocytomatosis viral oncogene homolog (MYC) and phosphoinositide-3-kinase, catalytic, alpha polypeptide (PIK3CA).

Detailed Description

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Conditions

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Non-small Cell Lung Cancer (NSCLC)

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Histologically confirmed diagnosis of advanced non-small cell lung cancer - Tumor tissue available at our institution
* Patients treated with single agent pemetrexed for metastatic disease
* Availability of full clinical data

Exclusion Criteria

* Cytological diagnosis of advanced Non-small cell lung cancer
* Lack of tumor tissue at our institution
* Lack of full clinical data
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Armando Santoro, MD

OTHER

Sponsor Role lead

Responsible Party

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Armando Santoro, MD

MD

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Armando SANTORO, MD

Role: PRINCIPAL_INVESTIGATOR

Istituto Clinico Humanitas

Locations

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Istituto Clinico Humanitas

Rozzano, Milano, Italy

Site Status

Countries

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Italy

Other Identifiers

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ONC/OSS-02/2010

Identifier Type: -

Identifier Source: org_study_id

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