Trial Outcomes & Findings for Epidemiology Study of Malaria Transmission Intensity in Africa (NCT NCT01190202)
NCT ID: NCT01190202
Last Updated: 2020-08-18
Results Overview
The Overall parasite prevalence (PP) data were collected across centers from subjects aged between and including: 6 months to 4 Years (6M-4Y), 5 to 19 Years (5-19 Y) and 20 Years or older (20Y+), for each Survey. The number of subjects P. Falciparum parasitemia infected among the number of subjects with known result for P.falciparum parasitemia test was tabulated.
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
21618 participants
Primary outcome timeframe
At each Survey visit
Results posted on
2020-08-18
Participant Flow
For each year and each site, approximately 400 subjects at least 6 months and \< 5 years old, approximately 200 subjects at least 5 years and \< 20 years old and approximately 200 subjects at least 20 years old were to be enrolled. The study was conducted at 8 sites and 6 countries for the first 3 surveys and 3 sites from 3 countries for Survey 4.
Participant milestones
| Measure |
Overall Study Group (Survey 1)
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
|---|---|---|---|---|
|
Overall Study
STARTED
|
6404
|
6414
|
6400
|
2400
|
|
Overall Study
COMPLETED
|
6404
|
6414
|
6400
|
2400
|
|
Overall Study
NOT COMPLETED
|
0
|
0
|
0
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Race and Ethnicity were not collected from any participant.
Baseline characteristics by cohort
| Measure |
Overall Study Group (Survey 1)
n=6404 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=6414 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=6400 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=2400 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Total
n=21618 Participants
Total of all reporting groups
|
|---|---|---|---|---|---|
|
Age, Continuous
|
12.6 Years
STANDARD_DEVIATION 14.6 • n=6404 Participants
|
12.1 Years
STANDARD_DEVIATION 14.3 • n=6414 Participants
|
12.1 Years
STANDARD_DEVIATION 14.2 • n=6400 Participants
|
12.4 Years
STANDARD_DEVIATION 14.4 • n=2400 Participants
|
12.28 Years
STANDARD_DEVIATION 14.37 • n=21618 Participants
|
|
Sex: Female, Male
Female
|
3670 Participants
n=6404 Participants
|
3791 Participants
n=6414 Participants
|
3752 Participants
n=6400 Participants
|
1420 Participants
n=2400 Participants
|
12633 Participants
n=21618 Participants
|
|
Sex: Female, Male
Male
|
2734 Participants
n=6404 Participants
|
2623 Participants
n=6414 Participants
|
2648 Participants
n=6400 Participants
|
980 Participants
n=2400 Participants
|
8985 Participants
n=21618 Participants
|
|
Race and Ethnicity Not Collected
|
—
|
—
|
—
|
—
|
0 Participants
Race and Ethnicity were not collected from any participant.
|
PRIMARY outcome
Timeframe: At each Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The Overall parasite prevalence (PP) data were collected across centers from subjects aged between and including: 6 months to 4 Years (6M-4Y), 5 to 19 Years (5-19 Y) and 20 Years or older (20Y+), for each Survey. The number of subjects P. Falciparum parasitemia infected among the number of subjects with known result for P.falciparum parasitemia test was tabulated.
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=6401 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=6411 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=6400 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=2399 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects With Plasmodium Falciparum (P. Falciparum) Parasitaemia (PFP), for Each Survey
6M-4Y, Overall
|
720 Participants
|
574 Participants
|
605 Participants
|
345 Participants
|
—
|
|
Number of Subjects With Plasmodium Falciparum (P. Falciparum) Parasitaemia (PFP), for Each Survey
5-19Y, Overall
|
446 Participants
|
469 Participants
|
483 Participants
|
278 Participants
|
—
|
|
Number of Subjects With Plasmodium Falciparum (P. Falciparum) Parasitaemia (PFP), for Each Survey
20+Y, Overall
|
147 Participants
|
146 Participants
|
193 Participants
|
92 Participants
|
—
|
SECONDARY outcome
Timeframe: At each Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The overall parasite prevalence (PP) data were collected across centers from subjects aged 4 years or less, for each Survey. The number of subjects P. Falciparum parasitemia infected among the number of subjects with known result for P.falciparum parasitemia test was tabulated.
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=3200 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=3197 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=3193 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=1193 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects With Plasmodium Falciparum (P. Falciparum) Parasitaemia (PFP), According to Annual Age for Children of 4 Years or Less, for Each Survey
Children aged 4 years
|
243 Participants
|
165 Participants
|
176 Participants
|
86 Participants
|
—
|
|
Number of Subjects With Plasmodium Falciparum (P. Falciparum) Parasitaemia (PFP), According to Annual Age for Children of 4 Years or Less, for Each Survey
Children aged 0 year
|
21 Participants
|
38 Participants
|
41 Participants
|
25 Participants
|
—
|
|
Number of Subjects With Plasmodium Falciparum (P. Falciparum) Parasitaemia (PFP), According to Annual Age for Children of 4 Years or Less, for Each Survey
Children aged 1 year
|
94 Participants
|
75 Participants
|
128 Participants
|
62 Participants
|
—
|
|
Number of Subjects With Plasmodium Falciparum (P. Falciparum) Parasitaemia (PFP), According to Annual Age for Children of 4 Years or Less, for Each Survey
Children aged 2 years
|
139 Participants
|
122 Participants
|
125 Participants
|
86 Participants
|
—
|
|
Number of Subjects With Plasmodium Falciparum (P. Falciparum) Parasitaemia (PFP), According to Annual Age for Children of 4 Years or Less, for Each Survey
Children aged 3 years
|
223 Participants
|
174 Participants
|
135 Participants
|
86 Participants
|
—
|
SECONDARY outcome
Timeframe: During the survey period (approximatively 1 year)Population: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The overall anemia and severe anemia data were collected across centers from subjects, aged between and including: 6M-4Y, 5-19 Y and 20Y+, for each survey. Hemoglobin (Hgb) cut-offs used to define anemia and severe anemia in people living at sea level are: Anemia: children 6M to 5Y, Hgb lower than (\<) 11 gram per deciliter (g/dL); children 5-11Y, Hgb \<11.5 g/dL; children 12-13Y, Hgb \<12 g/dL; non-pregnant females, Hgb \<12 g/dL; pregnant females, Hgb \<11 g/dL; males, Hgb \<13 g/dL. Severe anemia: any age or gender, Hgb \<7 g/dL. Missing/ Not applicable (NA) = if age or pregnancy status was not available. Among each age category, results for both sub-categories "Yes" (subjects with anemia) and "Missing/NA" are presented below, results for the category "No" can be deduced from the number of participants analyzed in the corresponding age category, minus (number of "Yes" + number of "Missing/NA"). Similar presentation is followed for "severe anemia" results.
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=6401 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=6411 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=6400 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=2399 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects With Anemia and Severe Anemia for Each Survey
Missing/NA Severe anemia, 20Y+
|
915 Participants
|
956 Participants
|
944 Participants
|
287 Participants
|
—
|
|
Number of Subjects With Anemia and Severe Anemia for Each Survey
Overall Yes, Anaemia, 6M-4Y
|
1974 Participants
|
2025 Participants
|
1974 Participants
|
871 Participants
|
—
|
|
Number of Subjects With Anemia and Severe Anemia for Each Survey
Missing/NA Anemia, 6M-4Y
|
4 Participants
|
2 Participants
|
—
|
—
|
—
|
|
Number of Subjects With Anemia and Severe Anemia for Each Survey
Overall Yes, Anemia, 5-19Y
|
806 Participants
|
794 Participants
|
765 Participants
|
371 Participants
|
—
|
|
Number of Subjects With Anemia and Severe Anemia for Each Survey
Missing/NA Anemia, 5-19Y
|
2 Participants
|
2 Participants
|
—
|
—
|
—
|
|
Number of Subjects With Anemia and Severe Anemia for Each Survey
Overall Yes, Anemia, 20Y+
|
673 Participants
|
631 Participants
|
651 Participants
|
313 Participants
|
—
|
|
Number of Subjects With Anemia and Severe Anemia for Each Survey
Missing/NA Anemia, 20Y+
|
1 Participants
|
0 Participants
|
—
|
—
|
—
|
|
Number of Subjects With Anemia and Severe Anemia for Each Survey
Overall Yes, Severe anaemia, 6M-4Y
|
85 Participants
|
70 Participants
|
84 Participants
|
34 Participants
|
—
|
|
Number of Subjects With Anemia and Severe Anemia for Each Survey
Missing/NA Severe anemia, 6M-4Y
|
1226 Participants
|
1172 Participants
|
1219 Participants
|
322 Participants
|
—
|
|
Number of Subjects With Anemia and Severe Anemia for Each Survey
Overall Yes, Severe anaemia, 5-19Y
|
10 Participants
|
12 Participants
|
19 Participants
|
5 Participants
|
—
|
|
Number of Subjects With Anemia and Severe Anemia for Each Survey
Missing/NA Severe anemia, 5-19Y
|
807 Participants
|
833 Participants
|
847 Participants
|
235 Participants
|
—
|
|
Number of Subjects With Anemia and Severe Anemia for Each Survey
Overall Yes, Severe anaemia, 20Y+
|
17 Participants
|
14 Participants
|
9 Participants
|
4 Participants
|
—
|
SECONDARY outcome
Timeframe: During the survey period (approximatively 1 year)Population: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The overall anti-malaria therapy data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg). Results include the following categories: Malaria treatment (MT) in past 14 days with sub-categories assessed: Yes, No; Exact days of malaria treatment (EDMT) with sub-categories assessed: Ongoing, 1-3 Days, ≥ 4 Days, Missing/NA; Other medication (OM) in past 14 days with sub-categories assessed: Yes, No; Days of other medication (DOM) with sub-categories assessed: Ongoing, 1-7 Days, ≥ 8 Days, Missing/NA; Malaria hospitalization (MH) in the last 3 months with sub-categories assessed: Yes, No. Missing/NA = Missing or Not Applicable.\* In case of several medication (malaria treatment or other medication) taken per subject, the maximum duration was computed for this study.
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=786 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=258 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=81 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=188 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5088 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
6M-4Y, MT in past 14 days, Yes
|
22 Participants
|
9 Participants
|
2 Participants
|
12 Participants
|
262 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
6M-4Y, MT in past 14 days, No
|
351 Participants
|
161 Participants
|
56 Participants
|
107 Participants
|
2218 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
6M-4Y, EDMT *, ≥ 4days
|
1 Participants
|
2 Participants
|
0 Participants
|
3 Participants
|
27 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
6M-4Y, EDMT *, Missing/Not applicable
|
351 Participants
|
161 Participants
|
56 Participants
|
107 Participants
|
2219 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
6M-4Y, MH in the last 3 months, No
|
366 Participants
|
166 Participants
|
57 Participants
|
112 Participants
|
2390 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
5-19Y, OM in past 14 days, No
|
265 Participants
|
59 Participants
|
15 Participants
|
51 Participants
|
1024 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
5-19Y, DOM *, Ongoing
|
4 Participants
|
1 Participants
|
1 Participants
|
2 Participants
|
17 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
5-19Y, DOM *, 1-7 days
|
25 Participants
|
11 Participants
|
7 Participants
|
5 Participants
|
125 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
20Y+, OM in past 14 days, No
|
99 Participants
|
11 Participants
|
—
|
9 Participants
|
1238 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
20Y+, DOM *, Ongoing
|
5 Participants
|
1 Participants
|
—
|
1 Participants
|
41 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
20Y+, DOM *, 1-7 days
|
15 Participants
|
5 Participants
|
—
|
1 Participants
|
158 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
20Y+, DOM *, ≥ 8 days
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
2 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
20Y+, DOM *, Missing/Not applicable
|
99 Participants
|
11 Participants
|
—
|
9 Participants
|
1240 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
6M-4Y, EDMT *, Ongoing
|
3 Participants
|
2 Participants
|
0 Participants
|
0 Participants
|
28 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
6M-4Y, EDMT *, 1-3 days
|
18 Participants
|
5 Participants
|
2 Participants
|
9 Participants
|
206 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
6M-4Y, OM in past 14 days, Yes
|
35 Participants
|
33 Participants
|
21 Participants
|
33 Participants
|
445 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
6M-4Y, OM in past 14 days, No
|
338 Participants
|
137 Participants
|
37 Participants
|
86 Participants
|
2035 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
6M-4Y, DOM *, Ongoing
|
8 Participants
|
7 Participants
|
2 Participants
|
5 Participants
|
79 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
6M-4Y, DOM *, 1-7 days
|
25 Participants
|
26 Participants
|
19 Participants
|
27 Participants
|
365 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
6M-4Y, DOM *, ≥ 8 days
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
6M-4Y, DOM *, Missing/Not applicable
|
340 Participants
|
137 Participants
|
37 Participants
|
87 Participants
|
2035 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
6M-4Y, MH in the last 3 months, Yes
|
7 Participants
|
4 Participants
|
1 Participants
|
7 Participants
|
90 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
5-19Y, MT in past 14 days, Yes
|
5 Participants
|
6 Participants
|
4 Participants
|
2 Participants
|
85 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
5-19Y, MT in past 14 days, No
|
289 Participants
|
65 Participants
|
19 Participants
|
56 Participants
|
1082 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
5-19Y, EDMT *, Ongoing
|
1 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
5 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
5-19Y, EDMT *, 1-3 days
|
4 Participants
|
6 Participants
|
4 Participants
|
1 Participants
|
75 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
5-19Y, EDMT *, ≥ 4days
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
5 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
5-19Y, EDMT *, Missing/Not applicable
|
289 Participants
|
65 Participants
|
19 Participants
|
56 Participants
|
1082 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
5-19Y, OM in past 14 days, Yes
|
29 Participants
|
12 Participants
|
8 Participants
|
7 Participants
|
143 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
5-19Y, DOM *, ≥ 8 days
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
5-19Y, DOM *, Missing/Not applicable
|
265 Participants
|
59 Participants
|
15 Participants
|
51 Participants
|
1025 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
5-19Y, MH in the last 3 months, Yes
|
0 Participants
|
3 Participants
|
0 Participants
|
1 Participants
|
24 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
5-19Y, MH in the last 3 months, No
|
294 Participants
|
68 Participants
|
23 Participants
|
57 Participants
|
1143 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
20Y+, MT in past 14 days, Yes
|
1 Participants
|
0 Participants
|
—
|
0 Participants
|
102 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
20Y+, MT in past 14 days, No
|
118 Participants
|
17 Participants
|
—
|
11 Participants
|
1339 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
20Y+, EDMT *, Ongoing
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
14 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
20Y+, EDMT *, 1-3 days
|
1 Participants
|
0 Participants
|
—
|
0 Participants
|
80 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
20Y+, EDMT *, ≥ 4days
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
8 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
20Y+, EDMT *, Missing/Not applicable
|
118 Participants
|
17 Participants
|
—
|
11 Participants
|
1339 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
20Y+, OM in past 14 days, Yes
|
20 Participants
|
6 Participants
|
—
|
2 Participants
|
203 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
20Y+, MH in the last 3 months, Yes
|
0 Participants
|
2 Participants
|
—
|
0 Participants
|
18 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
20Y+, MH in the last 3 months, No
|
119 Participants
|
15 Participants
|
—
|
11 Participants
|
1423 Participants
|
SECONDARY outcome
Timeframe: During the survey period (approximatively 1 year)Population: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The overall anti-malaria therapy data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg). Results include the following categories: Malaria treatment (MT) in past 14 days with sub-categories assessed: Yes, No; Exact days of malaria treatment (EDMT) with sub-categories assessed: Ongoing, 1-3 Days, ≥ 4 Days, Missing/NA; Other medication (OM) in past 14 days with sub-categories assessed: Yes, No; Days of other medication (DOM) with sub-categories assessed: Ongoing, 1-7 Days, ≥ 8 Days, Missing/NA; Malaria hospitalization (MH) in the last 3 months with sub-categories assessed: Yes, No. Missing/NA = Missing or Not Applicable.\* In case of several medication (malaria treatment or other medication) taken per subject, the maximum duration was computed for this study.
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=740 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=229 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=101 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=119 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5222 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
6M-4Y, EDMT *, 1-3 days
|
12 Participants
|
1 Participants
|
1 Participants
|
4 Participants
|
206 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
6M-4Y, DOM *, 1-7 days
|
30 Participants
|
9 Participants
|
6 Participants
|
15 Participants
|
410 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
6M-4Y, DOM *, ≥ 8 days
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
7 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
6M-4Y, DOM *, Missing/NA
|
241 Participants
|
133 Participants
|
58 Participants
|
59 Participants
|
2088 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
6M-4Y, MH in the last 3 months, Yes
|
3 Participants
|
3 Participants
|
2 Participants
|
3 Participants
|
77 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
6M-4Y, MH in the last 3 months, No
|
280 Participants
|
145 Participants
|
65 Participants
|
73 Participants
|
2546 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
5-19Y, MT in past 14 days, Yes
|
11 Participants
|
3 Participants
|
2 Participants
|
4 Participants
|
77 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
5-19Y, MT in past 14 days, No
|
322 Participants
|
68 Participants
|
27 Participants
|
32 Participants
|
1081 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
5-19Y, EDMT *, Ongoing
|
1 Participants
|
1 Participants
|
0 Participants
|
0 Participants
|
11 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
5-19Y, EDMT *, 1-3 days
|
8 Participants
|
1 Participants
|
2 Participants
|
4 Participants
|
66 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
5-19Y, EDMT *, ≥ 4days
|
2 Participants
|
1 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
5-19Y, EDMT *, Missing/NA
|
322 Participants
|
68 Participants
|
27 Participants
|
32 Participants
|
1081 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
5-19Y, OM in past 14 days, Yes
|
33 Participants
|
10 Participants
|
8 Participants
|
9 Participants
|
134 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
5-19Y, OM in past 14 days, No
|
300 Participants
|
61 Participants
|
21 Participants
|
27 Participants
|
1024 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
5-19Y, DOM *, Ongoing
|
7 Participants
|
1 Participants
|
0 Participants
|
1 Participants
|
30 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
5-19Y, DOM *, 1-7 days
|
26 Participants
|
9 Participants
|
8 Participants
|
8 Participants
|
102 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
5-19Y, DOM *, ≥ 8 days
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
2 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
5-19Y, DOM *, Missing/NA
|
300 Participants
|
61 Participants
|
21 Participants
|
27 Participants
|
1024 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
5-19Y, MH in the last 3 months, Yes
|
5 Participants
|
1 Participants
|
1 Participants
|
1 Participants
|
19 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
5-19Y, MH in the last 3 months, No
|
328 Participants
|
70 Participants
|
28 Participants
|
35 Participants
|
1139 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
20Y+, MT in past 14 days, Yes
|
2 Participants
|
0 Participants
|
0 Participants
|
2 Participants
|
84 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
20Y+, MT in past 14 days, No
|
122 Participants
|
10 Participants
|
5 Participants
|
5 Participants
|
1357 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
20Y+, EDMT *, Ongoing
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
5 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
20Y+, EDMT *, 1-3 days
|
2 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
72 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
20Y+, EDMT *, ≥ 4days
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
7 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
20Y+, EDMT *, Missing/NA
|
122 Participants
|
10 Participants
|
5 Participants
|
5 Participants
|
1357 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
20Y+, OM in past 14 days, Yes
|
10 Participants
|
2 Participants
|
2 Participants
|
3 Participants
|
214 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
20Y+, OM in past 14 days, No
|
114 Participants
|
8 Participants
|
3 Participants
|
4 Participants
|
1227 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
20Y+, DOM *, Ongoing
|
1 Participants
|
0 Participants
|
1 Participants
|
2 Participants
|
71 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
20Y+, DOM *, 1-7 days
|
9 Participants
|
2 Participants
|
1 Participants
|
1 Participants
|
138 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
20Y+, DOM *, ≥ 8 days
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
5 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
20Y+, DOM *, Missing/NA
|
114 Participants
|
8 Participants
|
3 Participants
|
4 Participants
|
1227 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
20Y+, MH in the last 3 months, Yes
|
1 Participants
|
1 Participants
|
0 Participants
|
0 Participants
|
19 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
20Y+, MH in the last 3 months, No
|
123 Participants
|
9 Participants
|
5 Participants
|
7 Participants
|
1422 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
6M-4Y, MT in past 14 days, Yes
|
14 Participants
|
6 Participants
|
2 Participants
|
5 Participants
|
257 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
6M-4Y, MT in past 14 days, No
|
269 Participants
|
142 Participants
|
65 Participants
|
71 Participants
|
2366 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
6M-4Y, EDMT *, Ongoing
|
1 Participants
|
3 Participants
|
0 Participants
|
1 Participants
|
25 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
6M-4Y, EDMT *, ≥ 4days
|
1 Participants
|
2 Participants
|
1 Participants
|
0 Participants
|
26 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
6M-4Y, EDMT *, Missing/NA
|
269 Participants
|
142 Participants
|
65 Participants
|
71 Participants
|
2366 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
6M-4Y, OM in past 14 days, Yes
|
42 Participants
|
15 Participants
|
9 Participants
|
17 Participants
|
535 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
6M-4Y, OM in past 14 days, No
|
241 Participants
|
133 Participants
|
58 Participants
|
59 Participants
|
2088 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
6M-4Y, DOM *, Ongoing
|
12 Participants
|
6 Participants
|
3 Participants
|
2 Participants
|
118 Participants
|
SECONDARY outcome
Timeframe: During the survey period (approximatively 1 year)Population: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The overall anti-malaria therapy data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg). Results include the following categories: Malaria treatment (MT) in past 14 days with sub-categories assessed: Yes, No; Exact days of malaria treatment (EDMT) with sub-categories assessed: Ongoing, 1-3 Days, ≥ 4 Days, Missing/NA; Other medication (OM) in past 14 days with sub-categories assessed: Yes, No; Days of other medication (DOM) with sub-categories assessed: Ongoing, 1-7 Days, ≥ 8 Days, Missing/NA; Malaria hospitalization (MH) in the last 3 months with sub-categories assessed: Yes, No. Missing/NA = Missing or Not Applicable.\* In case of several medication (malaria treatment or other medication) taken per subject, the maximum duration was computed for this study.
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=791 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=268 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=92 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=130 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5119 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
6M-4Y, MT in past 14 days, No
|
262 Participants
|
148 Participants
|
71 Participants
|
82 Participants
|
2321 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
5-19Y, MT in past 14 days, Yes
|
14 Participants
|
4 Participants
|
1 Participants
|
1 Participants
|
58 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
5-19Y, DOM *, Missing/NA
|
297 Participants
|
76 Participants
|
10 Participants
|
22 Participants
|
1001 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
5-19Y, MH in the last 3 months, Yes
|
7 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
17 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
5-19Y, MH in the last 3 months, No
|
334 Participants
|
94 Participants
|
13 Participants
|
34 Participants
|
1112 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
20Y+, EDMT *, 1-3 days
|
5 Participants
|
1 Participants
|
0 Participants
|
0 Participants
|
63 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
20Y+, EDMT *, Missing/NA
|
166 Participants
|
11 Participants
|
5 Participants
|
4 Participants
|
1332 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
6M-4Y, MT in past 14 days, Yes
|
17 Participants
|
13 Participants
|
3 Participants
|
9 Participants
|
267 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
6M-4Y, EDMT *, Ongoing
|
4 Participants
|
1 Participants
|
0 Participants
|
4 Participants
|
33 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
6M-4Y, EDMT *, 1-3 days
|
11 Participants
|
10 Participants
|
3 Participants
|
5 Participants
|
210 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
6M-4Y, EDMT *, ≥ 4days
|
2 Participants
|
2 Participants
|
0 Participants
|
0 Participants
|
24 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
6M-4Y, EDMT *, Missing/NA
|
262 Participants
|
148 Participants
|
71 Participants
|
82 Participants
|
2321 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
6M-4Y, OM in past 14 days, Yes
|
65 Participants
|
30 Participants
|
18 Participants
|
18 Participants
|
547 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
6M-4Y, OM in past 14 days, No
|
214 Participants
|
131 Participants
|
56 Participants
|
73 Participants
|
2041 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
6M-4Y, DOM *, Ongoing
|
10 Participants
|
8 Participants
|
3 Participants
|
6 Participants
|
142 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
6M-4Y, DOM *, 1-7 days
|
55 Participants
|
22 Participants
|
15 Participants
|
12 Participants
|
394 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
6M-4Y, DOM *, ≥ 8 days
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
11 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
6M-4Y, DOM *, Missing/NA
|
214 Participants
|
131 Participants
|
56 Participants
|
73 Participants
|
2041 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
6M-4Y, MH in the last 3 months, Yes
|
14 Participants
|
4 Participants
|
3 Participants
|
0 Participants
|
99 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
5-19Y, MT in past 14 days, No
|
327 Participants
|
90 Participants
|
12 Participants
|
34 Participants
|
1071 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
6M-4Y, MH in the last 3 months, No
|
265 Participants
|
157 Participants
|
71 Participants
|
91 Participants
|
2489 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
5-19Y, EDMT *, Ongoing
|
4 Participants
|
1 Participants
|
0 Participants
|
0 Participants
|
4 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
5-19Y, EDMT *, 1-3 days
|
8 Participants
|
3 Participants
|
1 Participants
|
1 Participants
|
50 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
5-19Y, EDMT *, ≥ 4days
|
2 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
4 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
5-19Y, EDMT *, Missing/NA
|
327 Participants
|
90 Participants
|
12 Participants
|
34 Participants
|
1071 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
5-19Y, OM in past 14 days, Yes
|
44 Participants
|
18 Participants
|
3 Participants
|
13 Participants
|
128 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
5-19Y, OM in past 14 days, No
|
297 Participants
|
76 Participants
|
10 Participants
|
22 Participants
|
1001 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
5-19Y, DOM *, Ongoing
|
13 Participants
|
1 Participants
|
0 Participants
|
2 Participants
|
19 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
5-19Y, DOM *, 1-7 days
|
31 Participants
|
17 Participants
|
3 Participants
|
11 Participants
|
109 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
5-19Y, DOM *, ≥ 8 days
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
20Y+, MT in past 14 days, Yes
|
5 Participants
|
2 Participants
|
0 Participants
|
0 Participants
|
70 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
20Y+, MT in past 14 days, No
|
166 Participants
|
11 Participants
|
5 Participants
|
4 Participants
|
1332 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
20Y+, EDMT *, Ongoing
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
6 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
20Y+, EDMT *, ≥ 4days
|
0 Participants
|
1 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
20Y+, OM in past 14 days, Yes
|
25 Participants
|
3 Participants
|
3 Participants
|
1 Participants
|
227 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
20Y+, OM in past 14 days, No
|
146 Participants
|
10 Participants
|
2 Participants
|
3 Participants
|
1175 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
20Y+, DOM *, Ongoing
|
5 Participants
|
3 Participants
|
0 Participants
|
1 Participants
|
70 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
20Y+, DOM *, 1-7 days
|
19 Participants
|
0 Participants
|
3 Participants
|
0 Participants
|
151 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
20Y+, DOM *, ≥ 8 days
|
1 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
6 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
20Y+, DOM *, Missing/NA
|
146 Participants
|
10 Participants
|
2 Participants
|
3 Participants
|
1175 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
20Y+, MH in the last 3 months, Yes
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
12 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
20Y+, MH in the last 3 months, No
|
171 Participants
|
13 Participants
|
5 Participants
|
4 Participants
|
1390 Participants
|
SECONDARY outcome
Timeframe: During the survey period (approximatively 1 year)Population: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The overall anti-malaria therapy data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg). Results include the following categories: Malaria treatment (MT) in past 14 days with sub-categories assessed: Yes, No; Exact days of malaria treatment (EDMT) with sub-categories assessed: Ongoing, 1-3 Days, ≥ 4 Days, Missing/NA; Other medication (OM) in past 14 days with sub-categories assessed: Yes, No; Days of other medication (DOM) with sub-categories assessed: Ongoing, 1-7 Days, ≥ 8 Days, Missing/NA; Malaria hospitalization (MH) in the last 3 months with sub-categories assessed: Yes, No. Missing/NA = Missing or Not Applicable.\* In case of several medication (malaria treatment or other medication) taken per subject, the maximum duration was computed for this study.
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=453 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=158 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=36 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=68 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=1684 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
20Y+, DOM *, Ongoing
|
1 Participants
|
0 Participants
|
—
|
0 Participants
|
18 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
6M-4Y, DOM *, Missing/NA
|
147 Participants
|
92 Participants
|
13 Participants
|
42 Participants
|
696 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
6M-4Y, MH in the last 3 months, No
|
159 Participants
|
102 Participants
|
20 Participants
|
52 Participants
|
820 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
5-19Y, EDMT *, Ongoing
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
3 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
20Y+, DOM *, ≥ 8 days
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
3 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
20Y+, MH in the last 3 months, Yes
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
5 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
20Y+, MH in the last 3 months, No
|
87 Participants
|
4 Participants
|
—
|
1 Participants
|
503 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
6M-4Y, DOM *, Ongoing
|
5 Participants
|
2 Participants
|
3 Participants
|
5 Participants
|
48 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
6M-4Y, EDMT *, 1-3 days
|
3 Participants
|
1 Participants
|
1 Participants
|
1 Participants
|
49 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
6M-4Y, EDMT *, ≥ 4days
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
6M-4Y, EDMT *, Missing/NA
|
163 Participants
|
101 Participants
|
19 Participants
|
49 Participants
|
777 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
6M-4Y, OM in past 14 days, Yes
|
21 Participants
|
11 Participants
|
7 Participants
|
12 Participants
|
152 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
6M-4Y, OM in past 14 days, No
|
147 Participants
|
92 Participants
|
13 Participants
|
42 Participants
|
696 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
6M-4Y, DOM *, 1-7 days
|
16 Participants
|
8 Participants
|
4 Participants
|
7 Participants
|
103 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
6M-4Y, DOM *, ≥ 8 days
|
0 Participants
|
1 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
6M-4Y, MH in the last 3 months, Yes
|
9 Participants
|
1 Participants
|
0 Participants
|
2 Participants
|
28 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
5-19Y, MT in past 14 days, Yes
|
2 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
10 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
5-19Y, MT in past 14 days, No
|
196 Participants
|
51 Participants
|
16 Participants
|
13 Participants
|
318 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
5-19Y, EDMT *, 1-3 days
|
2 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
7 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
5-19Y, EDMT *, ≥ 4days
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
5-19Y, EDMT *, Missing/NA
|
196 Participants
|
51 Participants
|
16 Participants
|
13 Participants
|
318 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
5-19Y, OM in past 14 days, Yes
|
13 Participants
|
4 Participants
|
0 Participants
|
2 Participants
|
28 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
5-19Y, OM in past 14 days, No
|
185 Participants
|
47 Participants
|
16 Participants
|
11 Participants
|
300 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
5-19Y, DOM *, Ongoing
|
1 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
6 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
5-19Y, DOM *, 1-7 days
|
12 Participants
|
4 Participants
|
0 Participants
|
1 Participants
|
22 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
5-19Y, DOM *, ≥ 8 days
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
5-19Y, DOM *, Missing/NA
|
185 Participants
|
47 Participants
|
16 Participants
|
11 Participants
|
300 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
5-19Y, MH in the last 3 months, Yes
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
2 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
5-19Y, MH in the last 3 months, No
|
198 Participants
|
51 Participants
|
16 Participants
|
13 Participants
|
326 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
20Y+, MT in past 14 days, Yes
|
1 Participants
|
0 Participants
|
—
|
0 Participants
|
8 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
20Y+, MT in past 14 days, No
|
86 Participants
|
4 Participants
|
—
|
1 Participants
|
500 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
20Y+, EDMT *, Ongoing
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
1 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
20Y+, EDMT *, 1-3 days
|
1 Participants
|
0 Participants
|
—
|
0 Participants
|
5 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
20Y+, EDMT *, ≥ 4days
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
2 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
20Y+, EDMT *, Missing/NA
|
86 Participants
|
4 Participants
|
—
|
1 Participants
|
500 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
20Y+, OM in past 14 days, Yes
|
5 Participants
|
0 Participants
|
—
|
0 Participants
|
57 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
20Y+, OM in past 14 days, No
|
82 Participants
|
4 Participants
|
—
|
1 Participants
|
451 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
20Y+, DOM *, 1-7 days
|
4 Participants
|
0 Participants
|
—
|
0 Participants
|
36 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
20Y+, DOM *, Missing/NA
|
82 Participants
|
4 Participants
|
—
|
1 Participants
|
451 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
6M-4Y, MT in past 14 days, Yes
|
5 Participants
|
2 Participants
|
1 Participants
|
5 Participants
|
71 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
6M-4Y, MT in past 14 days, No
|
163 Participants
|
101 Participants
|
19 Participants
|
49 Participants
|
777 Participants
|
|
Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
6M-4Y, EDMT *, Ongoing
|
2 Participants
|
1 Participants
|
0 Participants
|
4 Participants
|
21 Participants
|
SECONDARY outcome
Timeframe: During the 14 day-period before the malaria treatmentPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit and who have data available during the past 14 days period of Malaria treatment.
The mean and standard deviation of the number of days of malaria treatment (DMT) were calculated for the past 14 days period of treatment. The malaria treatment data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=24 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=13 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=6 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=14 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=401 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Mean Number of Days With Malaria Treatment at Survey 1
6M-4Y, DMT
|
2.6 Days
Standard Deviation 1.02
|
3.7 Days
Standard Deviation 1.70
|
2.5 Days
Standard Deviation 0.71
|
3.1 Days
Standard Deviation 0.67
|
3.1 Days
Standard Deviation 1.45
|
|
Mean Number of Days With Malaria Treatment at Survey 1
5-19Y, DMT
|
2.0 Days
Standard Deviation 0.82
|
2.2 Days
Standard Deviation 0.98
|
2.8 Days
Standard Deviation 0.50
|
3.5 Days
Standard Deviation 0.71
|
2.5 Days
Standard Deviation 1.09
|
|
Mean Number of Days With Malaria Treatment at Survey 1
20+Y, DMT
|
1.0 Days
Standard Deviation 0.00
|
—
|
—
|
—
|
2.6 Days
Standard Deviation 1.37
|
SECONDARY outcome
Timeframe: During the 14 day-period before the malaria treatmentPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit and who have data available during the past 14 days period of Malaria treatment.
The mean and standard deviation of the number of days of malaria treatment (DMT) were calculated for the past 14 days period of treatment. The malaria treatment data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=25 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=5 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=4 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=9 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=377 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Mean Number of Days With Malaria Treatment at Survey 2
6M-4Y, DMT
|
2.8 Days
Standard Deviation 1.48
|
5.7 Days
Standard Deviation 2.31
|
3.5 Days
Standard Deviation 0.71
|
2.0 Days
Standard Deviation 1.15
|
3.1 Days
Standard Deviation 1.16
|
|
Mean Number of Days With Malaria Treatment at Survey 2
5-19Y, DMT
|
2.8 Days
Standard Deviation 1.81
|
3.5 Days
Standard Deviation 2.12
|
3.0 Days
Standard Deviation 0.00
|
2.5 Days
Standard Deviation 1.00
|
2.5 Days
Standard Deviation 0.81
|
|
Mean Number of Days With Malaria Treatment at Survey 2
20+Y, DMT
|
3.0 Days
Standard Deviation 0.00
|
—
|
—
|
1.0 Days
Standard Deviation 0.00
|
2.5 Days
Standard Deviation 1.37
|
SECONDARY outcome
Timeframe: During the 14 day-period before the malaria treatmentPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit and who have data available during the past 14 days period of Malaria treatment.
The mean and standard deviation of the number of days of malaria treatment (DMT) were calculated for the past 14 days period of treatment. The malaria treatment data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=28 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=17 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=4 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=6 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=352 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Mean Number of Days With Malaria Treatment at Survey 3
6M-4Y, DMT
|
3.0 Days
Standard Deviation 0.71
|
3.3 Days
Standard Deviation 1.07
|
2.3 Days
Standard Deviation 1.15
|
2.2 Days
Standard Deviation 1.10
|
3.1 Days
Standard Deviation 1.08
|
|
Mean Number of Days With Malaria Treatment at Survey 3
5-19Y, DMT
|
3.9 Days
Standard Deviation 2.88
|
1.7 Days
Standard Deviation 1.15
|
3.0 Days
Standard Deviation 0.00
|
1.0 Days
Standard Deviation 0.00
|
2.9 Days
Standard Deviation 1.27
|
|
Mean Number of Days With Malaria Treatment at Survey 3
20+Y, DMT
|
1.4 Days
Standard Deviation 0.89
|
5.0 Days
Standard Deviation 2.83
|
—
|
—
|
2.3 Days
Standard Deviation 1.12
|
SECONDARY outcome
Timeframe: During the 14 day-period before the malaria treatmentPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit and who have data available during the past 14 days period of Malaria treatment.
The mean and standard deviation of the number of days of malaria treatment (DMT) were calculated for the past 14 days period of treatment. The malaria treatment data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=6 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=1 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=1 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=1 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=64 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Mean Number of Days With Malaria Treatment at Survey 4
6M-4Y, DMT
|
2.3 Days
Standard Deviation 1.15
|
3.0 Days
Standard Deviation 0.00
|
3.0 Days
Standard Deviation 0.00
|
1.0 Days
Standard Deviation 0.00
|
3.1 Days
Standard Deviation 0.59
|
|
Mean Number of Days With Malaria Treatment at Survey 4
5-19Y, DMT
|
3.0 Days
Standard Deviation 0.00
|
—
|
—
|
—
|
2.9 Days
Standard Deviation 0.38
|
|
Mean Number of Days With Malaria Treatment at Survey 4
20+Y, DMT
|
1.0 Days
Standard Deviation 0.00
|
—
|
—
|
—
|
3.3 Days
Standard Deviation 2.14
|
SECONDARY outcome
Timeframe: In the last 24 hours or at the survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
Measured characteristics of fever were the following: Fever in the last 24 hours (F 24h) and Fever at visit (F at V). Note: Fever set to "Yes" if temperature recorded after axillary conversion was ≥ 37.5 degrees Celsius (°C). Missing/NA = Missing or Not Applicable. Fever data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=786 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=258 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=81 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=188 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5088 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 1
6M-4Y, F at V - Missing/NA
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 1
20+Y, F 24h - No
|
89 Participants
|
8 Participants
|
—
|
9 Participants
|
1260 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 1
20+Y, F at V - Yes
|
3 Participants
|
0 Participants
|
—
|
1 Participants
|
23 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 1
6M-4Y, F 24h - Yes
|
71 Participants
|
53 Participants
|
21 Participants
|
60 Participants
|
361 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 1
6M-4Y, F 24h - No
|
302 Participants
|
117 Participants
|
37 Participants
|
59 Participants
|
2119 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 1
6M-4Y, F at V - Yes
|
26 Participants
|
13 Participants
|
7 Participants
|
22 Participants
|
79 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 1
6M-4Y, F at V - No
|
347 Participants
|
157 Participants
|
51 Participants
|
97 Participants
|
2400 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 1
5-19Y, F 24h - Yes
|
37 Participants
|
25 Participants
|
10 Participants
|
24 Participants
|
124 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 1
5-19Y, F 24h - No
|
257 Participants
|
46 Participants
|
13 Participants
|
34 Participants
|
1043 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 1
5-19Y, F at V - Yes
|
6 Participants
|
5 Participants
|
5 Participants
|
17 Participants
|
29 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 1
5-19Y, F at V - No
|
288 Participants
|
66 Participants
|
18 Participants
|
41 Participants
|
1138 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 1
20+Y, F 24h - Yes
|
30 Participants
|
9 Participants
|
—
|
2 Participants
|
181 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 1
20+Y, F at V - No
|
115 Participants
|
17 Participants
|
—
|
10 Participants
|
1418 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 1
20+Y, F at V - Missing/NA
|
1 Participants
|
0 Participants
|
—
|
0 Participants
|
0 Participants
|
SECONDARY outcome
Timeframe: In the last 24 hours or at the survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
Measured characteristics of fever were the following: Fever in the last 24 hours (F 24h) and Fever at visit (F at V). Note: Fever set to "Yes" if temperature recorded after axillary conversion was ≥ 37.5 degrees Celsius (°C). Missing/NA = Missing or Not Applicable. Fever data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=740 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=229 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=101 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=119 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5222 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 2
6M-4Y, F at V - No
|
257 Participants
|
132 Participants
|
52 Participants
|
47 Participants
|
2525 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 2
20+Y, F at V - No
|
114 Participants
|
10 Participants
|
5 Participants
|
6 Participants
|
1404 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 2
20+Y, F at V - Missing/NA
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 2
6M-4Y, F 24h - Yes
|
41 Participants
|
23 Participants
|
15 Participants
|
35 Participants
|
357 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 2
6M-4Y, F 24h - No
|
242 Participants
|
125 Participants
|
52 Participants
|
41 Participants
|
2266 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 2
6M-4Y, F at V - Yes
|
26 Participants
|
16 Participants
|
15 Participants
|
29 Participants
|
98 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 2
5-19Y, F 24h - Yes
|
39 Participants
|
11 Participants
|
11 Participants
|
13 Participants
|
115 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 2
5-19Y, F 24h - No
|
294 Participants
|
60 Participants
|
18 Participants
|
23 Participants
|
1043 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 2
5-19Y, F at V - Yes
|
24 Participants
|
4 Participants
|
3 Participants
|
8 Participants
|
26 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 2
5-19Y, F at V - No
|
309 Participants
|
67 Participants
|
26 Participants
|
28 Participants
|
1132 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 2
20+Y, F 24h - Yes
|
14 Participants
|
4 Participants
|
3 Participants
|
2 Participants
|
169 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 2
20+Y, F 24h - No
|
110 Participants
|
6 Participants
|
2 Participants
|
5 Participants
|
1272 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 2
20+Y, F at V - Yes
|
10 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
36 Participants
|
SECONDARY outcome
Timeframe: In the last 24 hours or at the survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
Measured characteristics of fever were the following: Fever in the last 24 hours (F 24h) and Fever at visit (F at V). Note: Fever set to "Yes" if temperature recorded after axillary conversion was ≥ 37.5 degrees Celsius (°C). Missing/NA = Missing or Not Applicable. Fever data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=791 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=268 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=92 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=130 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5119 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 3
6M-4Y, F 24h - Yes
|
60 Participants
|
44 Participants
|
28 Participants
|
44 Participants
|
360 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 3
6M-4Y, F at V - Yes
|
8 Participants
|
16 Participants
|
9 Participants
|
22 Participants
|
56 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 3
6M-4Y, F at V - No
|
271 Participants
|
145 Participants
|
65 Participants
|
69 Participants
|
2532 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 3
5-19Y, F at V - No
|
330 Participants
|
87 Participants
|
12 Participants
|
21 Participants
|
1107 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 3
5-19Y, F at V - Missing/NA
|
0 Participants
|
1 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 3
20+Y, F 24h - Yes
|
20 Participants
|
4 Participants
|
4 Participants
|
1 Participants
|
167 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 3
20+Y, F at V - No
|
166 Participants
|
13 Participants
|
2 Participants
|
3 Participants
|
1378 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 3
20+Y, F at V - Missing/NA
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 3
6M-4Y, F 24h - No
|
219 Participants
|
117 Participants
|
46 Participants
|
47 Participants
|
2228 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 3
5-19Y, F 24h - Yes
|
54 Participants
|
25 Participants
|
4 Participants
|
17 Participants
|
92 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 3
5-19Y, F 24h - No
|
287 Participants
|
69 Participants
|
9 Participants
|
18 Participants
|
1037 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 3
5-19Y, F at V - Yes
|
11 Participants
|
6 Participants
|
1 Participants
|
14 Participants
|
21 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 3
20+Y, F 24h - No
|
151 Participants
|
9 Participants
|
1 Participants
|
3 Participants
|
1235 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 3
20+Y, F at V - Yes
|
5 Participants
|
0 Participants
|
3 Participants
|
1 Participants
|
23 Participants
|
SECONDARY outcome
Timeframe: In the last 24 hours or at the survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
Measured characteristics of fever were the following: Fever in the last 24 hours (F 24h) and Fever at visit (F at V). Note: Fever set to "Yes" if temperature recorded after axillary conversion was ≥ 37.5 degrees Celsius (°C). Missing/NA = Missing or Not Applicable. Fever data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=453 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=158 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=36 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=68 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=1684 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 4
6M-4Y, F 24h - Yes
|
39 Participants
|
18 Participants
|
5 Participants
|
27 Participants
|
115 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 4
5-19Y, F 24h - Yes
|
38 Participants
|
8 Participants
|
4 Participants
|
4 Participants
|
22 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 4
20+Y, F 24h - Yes
|
11 Participants
|
0 Participants
|
—
|
0 Participants
|
25 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 4
20+Y, F at V - Yes
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
3 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 4
6M-4Y, F 24h - No
|
129 Participants
|
85 Participants
|
15 Participants
|
27 Participants
|
733 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 4
6M-4Y, F at V - Yes
|
8 Participants
|
8 Participants
|
4 Participants
|
18 Participants
|
20 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 4
6M-4Y, F at V - No
|
160 Participants
|
95 Participants
|
16 Participants
|
36 Participants
|
827 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 4
6M-4Y, F at V - Missing/NA
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 4
5-19Y, F 24h - No
|
160 Participants
|
43 Participants
|
12 Participants
|
9 Participants
|
306 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 4
5-19Y, F at V - Yes
|
5 Participants
|
0 Participants
|
2 Participants
|
1 Participants
|
4 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 4
5-19Y, F at V - No
|
193 Participants
|
51 Participants
|
14 Participants
|
12 Participants
|
324 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 4
20+Y, F 24h - No
|
76 Participants
|
4 Participants
|
—
|
1 Participants
|
483 Participants
|
|
Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 4
20+Y, F at V - No
|
87 Participants
|
4 Participants
|
—
|
1 Participants
|
505 Participants
|
SECONDARY outcome
Timeframe: During the survey period (approximatively 1 year)Population: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit and with fever reported in the last 24 hours.
The mean and standard deviation of the number of days ago with fever start (DaFs) were calculated for subjects having fever in the last 24 hours. Fever data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=138 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=87 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=31 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=86 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=663 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Mean Number of Days With Fever at Survey 1
6M-4Y, DaFs
|
2.5 Days
Standard Deviation 2.18
|
2.6 Days
Standard Deviation 2.23
|
2.1 Days
Standard Deviation 1.42
|
2.5 Days
Standard Deviation 4.13
|
2.3 Days
Standard Deviation 1.77
|
|
Mean Number of Days With Fever at Survey 1
5-19Y, DaFs
|
2.2 Days
Standard Deviation 1.41
|
2.2 Days
Standard Deviation 1.29
|
2.7 Days
Standard Deviation 2.06
|
1.7 Days
Standard Deviation 1.05
|
2.3 Days
Standard Deviation 1.93
|
|
Mean Number of Days With Fever at Survey 1
20+Y, DaFs
|
2.3 Days
Standard Deviation 1.56
|
2.3 Days
Standard Deviation 1.87
|
—
|
2.5 Days
Standard Deviation 0.71
|
2.9 Days
Standard Deviation 3.36
|
SECONDARY outcome
Timeframe: During the survey period (approximatively 1 year)Population: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit and with fever reported in the last 24 hours.
The mean and standard deviation of the number of days ago with fever start (DaFs) were calculated for subjects having fever in the last 24 hours. Fever data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=94 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=38 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=29 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=50 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=641 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Mean Number of Days With Fever at Survey 2
6M-4Y, DaFs
|
2.1 Days
Standard Deviation 1.35
|
2.7 Days
Standard Deviation 1.99
|
1.4 Days
Standard Deviation 0.51
|
2.0 Days
Standard Deviation 1.46
|
2.4 Days
Standard Deviation 1.76
|
|
Mean Number of Days With Fever at Survey 2
5-19Y, DaFs
|
2.5 Days
Standard Deviation 1.62
|
2.6 Days
Standard Deviation 2.38
|
2.5 Days
Standard Deviation 2.34
|
2.1 Days
Standard Deviation 1.80
|
2.1 Days
Standard Deviation 1.38
|
|
Mean Number of Days With Fever at Survey 2
20+Y, DaFs
|
4.0 Days
Standard Deviation 3.64
|
2.0 Days
Standard Deviation 1.15
|
2.0 Days
Standard Deviation 1.00
|
4.0 Days
Standard Deviation 2.83
|
3.2 Days
Standard Deviation 2.96
|
SECONDARY outcome
Timeframe: During the survey period (approximatively 1 year)Population: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit and with fever reported in the last 24 hours.
The mean and standard deviation of the number of days ago with fever start (DaFs) were calculated for subjects having fever in the last 24 hours. Fever data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=134 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=72 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=36 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=62 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=619 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Mean Number of Days With Fever at Survey 3
6M-4Y, DaFs
|
2.3 Days
Standard Deviation 1.90
|
2.4 Days
Standard Deviation 1.95
|
2.2 Days
Standard Deviation 1.33
|
2.1 Days
Standard Deviation 1.37
|
2.5 Days
Standard Deviation 1.80
|
|
Mean Number of Days With Fever at Survey 3
5-19Y, DaFs
|
2.3 Days
Standard Deviation 1.58
|
2.8 Days
Standard Deviation 1.63
|
2.5 Days
Standard Deviation 1.73
|
1.8 Days
Standard Deviation 0.53
|
2.7 Days
Standard Deviation 2.21
|
|
Mean Number of Days With Fever at Survey 3
20+Y, DaFs
|
3.0 Days
Standard Deviation 1.81
|
2.8 Days
Standard Deviation 0.50
|
3.8 Days
Standard Deviation 2.22
|
3.0 Days
Standard Deviation 0.00
|
3.3 Days
Standard Deviation 4.28
|
SECONDARY outcome
Timeframe: During the survey period (approximatively 1 year)Population: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit and with fever reported in the last 24 hours.
The mean and standard deviation of the number of days ago with fever start (DaFs) were calculated for subjects having fever in the last 24 hours. Fever data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=88 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=26 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=9 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=31 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=162 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Mean Number of Days With Fever at Survey 4
6M-4Y, DaFs
|
2.2 Days
Standard Deviation 1.05
|
2.4 Days
Standard Deviation 2.43
|
1.6 Days
Standard Deviation 0.89
|
2.2 Days
Standard Deviation 1.64
|
2.7 Days
Standard Deviation 1.88
|
|
Mean Number of Days With Fever at Survey 4
5-19Y, DaFs
|
2.0 Days
Standard Deviation 0.97
|
3.8 Days
Standard Deviation 2.38
|
1.5 Days
Standard Deviation 0.58
|
2.0 Days
Standard Deviation 1.15
|
2.1 Days
Standard Deviation 1.23
|
|
Mean Number of Days With Fever at Survey 4
20+Y, DaFs
|
2.5 Days
Standard Deviation 1.21
|
—
|
—
|
—
|
3.2 Days
Standard Deviation 1.38
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The mean and standard deviation of the axillary temperature at visit (A temp. at V) were calculated. Axillary temperature data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=785 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=258 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=81 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=188 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5087 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Axillary Temperature at Visit in Survey 1
20+Y, A temp. at V
|
36.55 Degrees Celsius
Standard Deviation 0.459
|
36.70 Degrees Celsius
Standard Deviation 0.387
|
—
|
36.82 Degrees Celsius
Standard Deviation 0.462
|
36.60 Degrees Celsius
Standard Deviation 0.478
|
|
Axillary Temperature at Visit in Survey 1
6M-4Y, A temp. at V
|
36.65 Degrees Celsius
Standard Deviation 0.521
|
36.64 Degrees Celsius
Standard Deviation 0.623
|
36.72 Degrees Celsius
Standard Deviation 0.782
|
37.04 Degrees Celsius
Standard Deviation 0.803
|
36.55 Degrees Celsius
Standard Deviation 0.522
|
|
Axillary Temperature at Visit in Survey 1
5-19Y, A temp. at V
|
36.56 Degrees Celsius
Standard Deviation 0.469
|
36.70 Degrees Celsius
Standard Deviation 0.597
|
37.07 Degrees Celsius
Standard Deviation 0.853
|
37.29 Degrees Celsius
Standard Deviation 0.928
|
36.63 Degrees Celsius
Standard Deviation 0.496
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The mean and standard deviation of axillary temperature at visit (A temp. at V) were calculated. Axillary temperature data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=740 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=229 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=101 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=119 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5221 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Axillary Temperature at Visit in Survey 2
20+Y, A temp. at V
|
36.70 Degrees Celsius
Standard Deviation 0.478
|
36.75 Degrees Celsius
Standard Deviation 0.375
|
36.64 Degrees Celsius
Standard Deviation 0.559
|
37.09 Degrees Celsius
Standard Deviation 0.713
|
36.67 Degrees Celsius
Standard Deviation 0.430
|
|
Axillary Temperature at Visit in Survey 2
6M-4Y, A temp. at V
|
36.69 Degrees Celsius
Standard Deviation 0.574
|
36.75 Degrees Celsius
Standard Deviation 0.628
|
36.86 Degrees Celsius
Standard Deviation 0.725
|
37.41 Degrees Celsius
Standard Deviation 1.201
|
36.60 Degrees Celsius
Standard Deviation 0.479
|
|
Axillary Temperature at Visit in Survey 2
5-19Y, A temp. at V
|
36.70 Degrees Celsius
Standard Deviation 0.522
|
36.76 Degrees Celsius
Standard Deviation 0.507
|
36.76 Degrees Celsius
Standard Deviation 0.773
|
37.36 Degrees Celsius
Standard Deviation 0.949
|
36.66 Degrees Celsius
Standard Deviation 0.447
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The mean and standard deviation of axillary temperature at visit (A temp. at V) were calculated. Axillary temperature data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=791 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=267 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=92 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=130 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5117 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Axillary Temperature at Visit in Survey 3
6M-4Y, A temp. at V
|
36.47 Degrees Celsius
Standard Deviation 0.517
|
36.66 Degrees Celsius
Standard Deviation 0.652
|
36.68 Degrees Celsius
Standard Deviation 0.701
|
36.97 Degrees Celsius
Standard Deviation 0.951
|
36.54 Degrees Celsius
Standard Deviation 0.496
|
|
Axillary Temperature at Visit in Survey 3
20+Y, A temp. at V
|
36.44 Degrees Celsius
Standard Deviation 0.515
|
36.42 Degrees Celsius
Standard Deviation 0.409
|
37.54 Degrees Celsius
Standard Deviation 1.135
|
37.18 Degrees Celsius
Standard Deviation 0.727
|
36.55 Degrees Celsius
Standard Deviation 0.493
|
|
Axillary Temperature at Visit in Survey 3
5-19Y, A temp. at V
|
36.56 Degrees Celsius
Standard Deviation 0.551
|
36.66 Degrees Celsius
Standard Deviation 0.571
|
36.61 Degrees Celsius
Standard Deviation 0.475
|
37.45 Degrees Celsius
Standard Deviation 1.117
|
36.59 Degrees Celsius
Standard Deviation 0.462
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The mean and standard deviation of axillary temperature at visit (A temp. at V) were calculated. Axillary temperature data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=453 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=158 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=36 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=68 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=1683 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Axillary Temperature at Visit in Survey 4
6M-4Y, A temp. at V
|
36.51 Degrees Celsius
Standard Deviation 0.508
|
36.51 Degrees Celsius
Standard Deviation 0.535
|
36.95 Degrees Celsius
Standard Deviation 0.927
|
37.16 Degrees Celsius
Standard Deviation 1.187
|
36.40 Degrees Celsius
Standard Deviation 0.492
|
|
Axillary Temperature at Visit in Survey 4
5-19Y, A temp. at V
|
36.53 Degrees Celsius
Standard Deviation 0.510
|
36.55 Degrees Celsius
Standard Deviation 0.379
|
36.53 Degrees Celsius
Standard Deviation 0.570
|
36.61 Degrees Celsius
Standard Deviation 0.431
|
36.38 Degrees Celsius
Standard Deviation 0.430
|
|
Axillary Temperature at Visit in Survey 4
20+Y, A temp. at V
|
36.42 Degrees Celsius
Standard Deviation 0.444
|
36.68 Degrees Celsius
Standard Deviation 0.206
|
—
|
36.50 Degrees Celsius
Standard Deviation 0.000
|
36.39 Degrees Celsius
Standard Deviation 0.457
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The malaria prevention and risk factors characteristics were: Number of persons living in the same part of the house (PLSPH) among persons enrolled in the study (PES), in the following combinations: \< y/x (less than \[\<\] y PLSPH among x PES), y-z/x (y to z PLSPH among x PES), \> z/x (more than \[\>\] z PLSPH among x PES), y-z/\> x (y to z PLSPH among more than \[\>\] x PES), \> z/\> x (more than \[\>\] z PLSPH among more than \[\>\] x PES, or missing information). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=786 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=258 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=81 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=188 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5088 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects Living in the Same House at Survey 1
6M-4Y, PLSPH/PES, <3/1
|
34 Participants
|
13 Participants
|
3 Participants
|
2 Participants
|
78 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
6M-4Y, PLSPH/PES, >5/1
|
20 Participants
|
10 Participants
|
0 Participants
|
3 Participants
|
123 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
6M-4Y, PLSPH/PES, 4-5/2
|
106 Participants
|
49 Participants
|
13 Participants
|
36 Participants
|
737 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
6M-4Y, PLSPH/PES, <3/3
|
1 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
3 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
6M-4Y, PLSPH/PES, >5/3
|
13 Participants
|
7 Participants
|
4 Participants
|
1 Participants
|
45 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
6M-4Y, PLSPH/PES, 4-5/>3
|
0 Participants
|
0 Participants
|
1 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
6M-4Y, Missing
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
5-19Y, PLSPH/PES, <3/1
|
20 Participants
|
6 Participants
|
0 Participants
|
0 Participants
|
28 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
5-19Y, PLSPH/PES, >5/2
|
111 Participants
|
38 Participants
|
10 Participants
|
34 Participants
|
560 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
5-19Y, PLSPH/PES, 4-5/>3
|
1 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
20+Y, PLSPH/PES, >5/1
|
6 Participants
|
1 Participants
|
—
|
0 Participants
|
26 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
20+Y, PLSPH/PES, <3/2
|
22 Participants
|
2 Participants
|
—
|
2 Participants
|
234 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
20+Y, PLSPH/PES, 4-5/2
|
40 Participants
|
7 Participants
|
—
|
3 Participants
|
449 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
20+Y, PLSPH/PES, >5/2
|
33 Participants
|
7 Participants
|
—
|
6 Participants
|
575 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
20+Y, PLSPH/PES, <3/3
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
2 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
20+Y, PLSPH/PES, 4-5/3
|
3 Participants
|
0 Participants
|
—
|
0 Participants
|
18 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
20+Y, PLSPH/PES, 4-5/>3
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
1 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
20+Y, PLSPH/PES, >5/>3
|
1 Participants
|
0 Participants
|
—
|
0 Participants
|
18 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
6M-4Y, PLSPH/PES, 4-5/1
|
32 Participants
|
15 Participants
|
1 Participants
|
2 Participants
|
146 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
20+Y, PLSPH/PES, >5/3
|
10 Participants
|
0 Participants
|
—
|
0 Participants
|
51 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
20+Y, Missing
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
2 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
6M-4Y, PLSPH/PES, <3/2
|
46 Participants
|
14 Participants
|
6 Participants
|
14 Participants
|
280 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
6M-4Y, PLSPH/PES, >5/2
|
119 Participants
|
59 Participants
|
28 Participants
|
59 Participants
|
1038 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
6M-4Y, PLSPH/PES, 4-5/3
|
1 Participants
|
1 Participants
|
1 Participants
|
1 Participants
|
19 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
6M-4Y, PLSPH/PES, >5/>3
|
1 Participants
|
2 Participants
|
1 Participants
|
1 Participants
|
9 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
5-19Y, PLSPH/PES, 4-5/1
|
14 Participants
|
2 Participants
|
1 Participants
|
1 Participants
|
17 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
5-19Y, PLSPH/PES, >5/1
|
8 Participants
|
3 Participants
|
1 Participants
|
0 Participants
|
37 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
5-19Y, PLSPH/PES, <3/2
|
19 Participants
|
4 Participants
|
1 Participants
|
5 Participants
|
75 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
5-19Y, PLSPH/PES, 4-5/2
|
76 Participants
|
13 Participants
|
9 Participants
|
17 Participants
|
357 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
5-19Y, PLSPH/PES, <3/3
|
0 Participants
|
1 Participants
|
0 Participants
|
0 Participants
|
2 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
5-19Y, PLSPH/PES, 4-5/3
|
10 Participants
|
1 Participants
|
0 Participants
|
0 Participants
|
14 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
5-19Y, PLSPH/PES, >5/3
|
25 Participants
|
2 Participants
|
1 Participants
|
1 Participants
|
59 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
5-19Y, PLSPH/PES, >5/>3
|
10 Participants
|
1 Participants
|
0 Participants
|
0 Participants
|
17 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
5-19Y, Missing
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
20+Y, PLSPH/PES, <3/1
|
3 Participants
|
0 Participants
|
—
|
0 Participants
|
49 Participants
|
|
Number of Subjects Living in the Same House at Survey 1
20+Y, PLSPH/PES, 4-5/1
|
1 Participants
|
0 Participants
|
—
|
0 Participants
|
16 Participants
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The malaria prevention and risk factors characteristics were: Number of persons living in the same part of the house (PLSPH) among persons enrolled in the study (PES), in the following combinations: \< y/x (less than \[\<\] y PLSPH among x PES), y-z/x (y to z PLSPH among x PES), \> z/x (more than \[\>\] z PLSPH among x PES), y-z/\> x (y to z PLSPH among more than \[\>\] x PES), \> z/\> x (more than \[\>\] z PLSPH among more than \[\>\] x PES, or missing information). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=740 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=229 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=101 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=119 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5222 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects Living in the Same House at Survey 2
6M-4Y, PLSPH/PES, <3/1
|
27 Participants
|
18 Participants
|
8 Participants
|
2 Participants
|
59 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
6M-4Y, PLSPH/PES, 4-5/1
|
33 Participants
|
18 Participants
|
8 Participants
|
3 Participants
|
112 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
6M-4Y, PLSPH/PES, >5/2
|
76 Participants
|
32 Participants
|
19 Participants
|
27 Participants
|
1059 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
6M-4Y, PLSPH/PES, 4-5/3
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
11 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
6M-4Y, PLSPH/PES, >5/3
|
3 Participants
|
1 Participants
|
4 Participants
|
2 Participants
|
24 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
6M-4Y, PLSPH/PES, 4-5/>3
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
2 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
6M-4Y, PLSPH/PES, >5/>3
|
0 Participants
|
1 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
5-19Y, PLSPH/PES, <3/1
|
34 Participants
|
3 Participants
|
1 Participants
|
3 Participants
|
23 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
5-19Y, PLSPH/PES, 4-5/2
|
98 Participants
|
17 Participants
|
10 Participants
|
13 Participants
|
426 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
5-19Y, PLSPH/PES, >5/2
|
105 Participants
|
28 Participants
|
15 Participants
|
17 Participants
|
548 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
5-19Y, PLSPH/PES, >5/3
|
14 Participants
|
4 Participants
|
1 Participants
|
1 Participants
|
20 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
20+Y, PLSPH/PES, 4-5/3
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
9 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
20+Y, PLSPH/PES, >5/3
|
3 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
25 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
6M-4Y, PLSPH/PES, <3/3
|
1 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
2 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
6M-4Y, PLSPH/PES, >5/1
|
13 Participants
|
9 Participants
|
3 Participants
|
4 Participants
|
84 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
6M-4Y, PLSPH/PES, <3/2
|
37 Participants
|
21 Participants
|
8 Participants
|
14 Participants
|
306 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
6M-4Y, PLSPH/PES, 4-5/2
|
93 Participants
|
48 Participants
|
17 Participants
|
24 Participants
|
964 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
5-19Y, PLSPH/PES, 4-5/1
|
30 Participants
|
13 Participants
|
2 Participants
|
0 Participants
|
20 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
5-19Y, PLSPH/PES, >5/1
|
16 Participants
|
3 Participants
|
0 Participants
|
0 Participants
|
38 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
5-19Y, PLSPH/PES, <3/2
|
30 Participants
|
3 Participants
|
0 Participants
|
2 Participants
|
69 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
5-19Y, PLSPH/PES, <3/3
|
2 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
5-19Y, PLSPH/PES, 4-5/3
|
4 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
9 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
5-19Y, PLSPH/PES, 4-5/>3
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
4 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
5-19Y, PLSPH/PES, >5/>3
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
20+Y, PLSPH-PES, <3/1
|
14 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
40 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
20+Y, PLSPH/PES, 4-5/1
|
8 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
26 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
20+Y, PLSPH/PES, >5/1
|
5 Participants
|
0 Participants
|
1 Participants
|
0 Participants
|
51 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
20+Y, PLSPH/PES, <3/2
|
34 Participants
|
2 Participants
|
1 Participants
|
2 Participants
|
253 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
20+Y, PLSPH/PES, 4-5/2
|
39 Participants
|
3 Participants
|
0 Participants
|
2 Participants
|
553 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
20+Y, PLSPH/PES, >5/2
|
21 Participants
|
5 Participants
|
3 Participants
|
3 Participants
|
476 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
20+Y, PLSPH/PES, <3/3
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
3 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
20+Y, PLSPH/PES, 4-5/>3
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
2 Participants
|
|
Number of Subjects Living in the Same House at Survey 2
20+Y, PLSPH/PES, >5/>3
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
3 Participants
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The malaria prevention and risk factors characteristics were: Number of persons living in the same part of the house (PLSPH) among persons enrolled in the study (PES), in the following combinations: \< y/x (less than \[\<\] y PLSPH among x PES), y-z/x (y to z PLSPH among x PES), \> z/x (more than \[\>\] z PLSPH among x PES), y-z/\> x (y to z PLSPH among more than \[\>\] x PES), \> z/\> x (more than \[\>\] z PLSPH among more than \[\>\] x PES, or missing information). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=791 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=268 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=92 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=130 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5119 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects Living in the Same House at Survey 3
6M-4Y, PLSPH/PES, >5/2
|
75 Participants
|
44 Participants
|
19 Participants
|
26 Participants
|
984 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
6M-4Y, PLSPH/PES, 4-5/3
|
2 Participants
|
0 Participants
|
1 Participants
|
0 Participants
|
11 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
6M-4Y, PLSPH/PES, >5/3
|
6 Participants
|
11 Participants
|
1 Participants
|
2 Participants
|
29 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
6M-4Y, PLSPH/PES, >5/>3
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
5-19Y, PLSPH/PES, <3/1
|
40 Participants
|
9 Participants
|
1 Participants
|
1 Participants
|
24 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
5-19Y, PLSPH/PES, <3/2
|
24 Participants
|
13 Participants
|
0 Participants
|
2 Participants
|
88 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
5-19Y, PLSPH/PES, 4-5/2
|
74 Participants
|
25 Participants
|
5 Participants
|
13 Participants
|
421 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
5-19Y, PLSPH/PES, >5/2
|
103 Participants
|
36 Participants
|
7 Participants
|
15 Participants
|
507 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
5-19Y, PLSPH/PES, <3/3
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
5-19Y, PLSPH/PES, 4-5/3
|
7 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
7 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
5-19Y, PLSPH/PES, >5/3
|
30 Participants
|
2 Participants
|
0 Participants
|
0 Participants
|
17 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
5-19Y, PLSPH/PES, 4-5/>3
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
20+Y, PLSPH/PES, <3/1
|
18 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
40 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
20+Y, PLSPH/PES, >5/2
|
28 Participants
|
6 Participants
|
2 Participants
|
3 Participants
|
463 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
20+Y, PLSPH/PES, >5/3
|
13 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
36 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
6M-4Y, PLSPH/PES, <3/1
|
31 Participants
|
16 Participants
|
7 Participants
|
11 Participants
|
63 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
6M-4Y, PLSPH/PES, 4-5/1
|
31 Participants
|
26 Participants
|
8 Participants
|
11 Participants
|
94 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
6M-4Y, PLSPH/PES, >5/1
|
15 Participants
|
10 Participants
|
6 Participants
|
2 Participants
|
94 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
6M-4Y, PLSPH/PES, <3/2
|
43 Participants
|
24 Participants
|
13 Participants
|
17 Participants
|
340 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
6M-4Y, PLSPH/PES, 4-5/2
|
76 Participants
|
30 Participants
|
19 Participants
|
22 Participants
|
973 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
6M-4Y, PLSPH/PES, <3/3
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
6M-4Y, PLSPH/PES, 4-5/>3
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
5-19Y, PLSPH/PES, 4-5/1
|
32 Participants
|
8 Participants
|
0 Participants
|
1 Participants
|
23 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
5-19Y, PLSPH/PES, >5/1
|
31 Participants
|
1 Participants
|
0 Participants
|
3 Participants
|
42 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
5-19Y, PLSPH/PES, >5/>3
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
20+Y, PLSPH/PES, 4-5/1
|
7 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
27 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
20+Y, PLSPH/PES, >5/1
|
5 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
33 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
20+Y, PLSPH/PES, <3/2
|
43 Participants
|
3 Participants
|
0 Participants
|
1 Participants
|
273 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
20+Y, PLSPH/PES, 4-5/2
|
57 Participants
|
4 Participants
|
3 Participants
|
0 Participants
|
516 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
20+Y, PLSPH/PES, <3/3
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
20+Y, PLSPH/PES, 4-5/3
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
14 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
20+Y, PLSPH/PES, 4-5/>3
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects Living in the Same House at Survey 3
20+Y, PLSPH/PES, >5/>3
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The malaria prevention and risk factors characteristics were: Number of persons living in the same part of the house (PLSPH) among persons enrolled in the study (PES), in the following combinations: \< y/x (less than \[\<\] y PLSPH among x PES), y-z/x (y to z PLSPH among x PES), \> z/x (more than \[\>\] z PLSPH among x PES), y-z/\> x (y to z PLSPH among more than \[\>\] x PES), \> z/\> x (more than \[\>\] z PLSPH among more than \[\>\] x PES, or missing information). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=453 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=158 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=36 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=68 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=1684 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects Living in the Same House at Survey 4
6M-4Y, PLSPH/PES, >5/2
|
25 Participants
|
12 Participants
|
4 Participants
|
12 Participants
|
338 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
5-19Y, PLSPH/PES, >5/3
|
42 Participants
|
9 Participants
|
3 Participants
|
1 Participants
|
38 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
5-19Y, PLSPH/PES, >5/>3
|
5 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
5 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
20+Y, PLSPH/PES, <3/2
|
23 Participants
|
0 Participants
|
—
|
0 Participants
|
81 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
20+Y, PLSPH/PES, <3/3
|
1 Participants
|
0 Participants
|
—
|
0 Participants
|
3 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
20+Y, PLSPH/PES, 4-5/3
|
2 Participants
|
0 Participants
|
—
|
1 Participants
|
3 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
20+Y, PLSPH/PES, >5/3
|
11 Participants
|
1 Participants
|
—
|
0 Participants
|
67 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
20+Y, PLSPH/PES, >5/>3
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
5 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
5-19Y, PLSPH/PES, 4-5/>3
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
2 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
20+Y, PLSPH/PES, <3/1
|
4 Participants
|
0 Participants
|
—
|
0 Participants
|
20 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
20+Y, PLSPH/PES, 4-5/1
|
4 Participants
|
0 Participants
|
—
|
0 Participants
|
8 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
20+Y, PLSPH/PES, >5/1
|
1 Participants
|
0 Participants
|
—
|
0 Participants
|
10 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
20+Y, PLSPH/PES, 4-5/2
|
26 Participants
|
2 Participants
|
—
|
0 Participants
|
119 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
20+Y, PLSPH/PES, >5/2
|
15 Participants
|
1 Participants
|
—
|
0 Participants
|
191 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
20+Y, PLSPH/PES, 4-5/>3
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
1 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
6M-4Y, PLSPH/PES, <3/1
|
28 Participants
|
21 Participants
|
2 Participants
|
7 Participants
|
42 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
6M-4Y, PLSPH/PES, 4-5/1
|
24 Participants
|
14 Participants
|
4 Participants
|
5 Participants
|
74 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
6M-4Y, PLSPH/PES, >5/1
|
18 Participants
|
7 Participants
|
1 Participants
|
5 Participants
|
59 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
6M-4Y, PLSPH/PES, <3/2
|
27 Participants
|
18 Participants
|
3 Participants
|
10 Participants
|
74 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
6M-4Y, PLSPH/PES, 4-5/2
|
30 Participants
|
23 Participants
|
3 Participants
|
13 Participants
|
184 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
6M-4Y, PLSPH-PES, <3/3
|
0 Participants
|
0 Participants
|
1 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
6M-4Y, PLSPH/PES, 4-5/3
|
1 Participants
|
1 Participants
|
0 Participants
|
1 Participants
|
9 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
6M-4Y, PLSPH/PES, >5/3
|
14 Participants
|
7 Participants
|
2 Participants
|
1 Participants
|
62 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
6M-4Y, PLSPH/PES, 4-5/>3
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
6M-4Y, PLSPH/PES, >5/>3
|
1 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
4 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
5-19Y, PLSPH/PES, <3/1
|
36 Participants
|
5 Participants
|
2 Participants
|
2 Participants
|
17 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
5-19Y, PLSPH/PES, 4-5/1
|
35 Participants
|
11 Participants
|
1 Participants
|
2 Participants
|
23 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
5-19Y, PLSPH/PES, >5/1
|
4 Participants
|
2 Participants
|
2 Participants
|
1 Participants
|
7 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
5-19Y, PLSPH/PES, <3/2
|
13 Participants
|
5 Participants
|
2 Participants
|
0 Participants
|
10 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
5-19Y, PLSPH/PES, 4-5/2
|
27 Participants
|
8 Participants
|
3 Participants
|
3 Participants
|
65 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
5-19Y, PLSPH/PES, >5/2
|
31 Participants
|
10 Participants
|
3 Participants
|
4 Participants
|
149 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
5-19Y, PLSPH/PES, <3/3
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects Living in the Same House at Survey 4
5-19Y, PLSPH/PES, 4-5/3
|
5 Participants
|
1 Participants
|
0 Participants
|
0 Participants
|
12 Participants
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The malaria prevention and risk factors characteristics were the following: the mean and standard deviation of the number of persons living in the same part of the house (PLSPH). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=786 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=258 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=81 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=188 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5088 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Mean Number of Subjects Living in the Same House at Survey 1
6M-4Y, PLSPH
|
6.4 Persons
Standard Deviation 4.83
|
6.3 Persons
Standard Deviation 4.23
|
6.5 Persons
Standard Deviation 3.98
|
5.8 Persons
Standard Deviation 2.14
|
6.5 Persons
Standard Deviation 4.28
|
|
Mean Number of Subjects Living in the Same House at Survey 1
5-19Y, PLSPH
|
6.9 Persons
Standard Deviation 4.55
|
6.6 Persons
Standard Deviation 3.53
|
5.9 Persons
Standard Deviation 1.91
|
6.5 Persons
Standard Deviation 3.04
|
7.1 Persons
Standard Deviation 4.69
|
|
Mean Number of Subjects Living in the Same House at Survey 1
20+Y, PLSPH
|
6.1 Persons
Standard Deviation 4.15
|
7.4 Persons
Standard Deviation 5.21
|
—
|
6.2 Persons
Standard Deviation 2.99
|
6.3 Persons
Standard Deviation 4.24
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The malaria prevention and risk factors characteristics were the following: the mean and standard deviation of the number of persons living in the same part of the house (PLSPH). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=740 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=229 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=101 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=119 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5222 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Mean Number of Subjects Living in the Same House at Survey 2
6M-4Y, PLSPH
|
5.1 Persons
Standard Deviation 2.90
|
5.0 Persons
Standard Deviation 2.17
|
5.1 Persons
Standard Deviation 2.34
|
5.4 Persons
Standard Deviation 2.62
|
5.8 Persons
Standard Deviation 2.66
|
|
Mean Number of Subjects Living in the Same House at Survey 2
5-19Y, PLSPH
|
5.5 Persons
Standard Deviation 2.64
|
6.1 Persons
Standard Deviation 2.78
|
5.9 Persons
Standard Deviation 1.89
|
5.9 Persons
Standard Deviation 2.81
|
6.2 Persons
Standard Deviation 2.78
|
|
Mean Number of Subjects Living in the Same House at Survey 2
20+Y, PLSPH
|
4.7 Persons
Standard Deviation 3.35
|
6.5 Persons
Standard Deviation 3.24
|
7.8 Persons
Standard Deviation 3.27
|
5.3 Persons
Standard Deviation 2.56
|
5.4 Persons
Standard Deviation 2.64
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The malaria prevention and risk factors characteristics were the following: the mean and standard deviation of the number of persons living in the same part of the house (PLSPH). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=791 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=268 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=92 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=130 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5119 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Mean Number of Subjects Living in the Same House at Survey 3
6M-4Y, PLSPH
|
5.1 Persons
Standard Deviation 2.73
|
5.4 Persons
Standard Deviation 2.74
|
5.1 Persons
Standard Deviation 3.40
|
5.0 Persons
Standard Deviation 2.43
|
5.6 Persons
Standard Deviation 2.48
|
|
Mean Number of Subjects Living in the Same House at Survey 3
5-19Y, PLSPH
|
5.9 Persons
Standard Deviation 3.25
|
5.1 Persons
Standard Deviation 2.04
|
5.5 Persons
Standard Deviation 1.85
|
5.8 Persons
Standard Deviation 2.06
|
6.0 Persons
Standard Deviation 2.42
|
|
Mean Number of Subjects Living in the Same House at Survey 3
20+Y, PLSPH
|
4.5 Persons
Standard Deviation 2.16
|
5.9 Persons
Standard Deviation 3.23
|
5.4 Persons
Standard Deviation 1.14
|
6.5 Persons
Standard Deviation 2.89
|
5.4 Persons
Standard Deviation 2.77
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The malaria prevention and risk factors characteristics were the following: the mean and standard deviation of the number of persons living in the same part of the house (PLSPH). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=453 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=158 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=36 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=68 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=1684 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Mean Number of Subjects Living in the Same House at Survey 4
6M-4Y, PLSPH
|
5.4 Persons
Standard Deviation 3.12
|
5.1 Persons
Standard Deviation 3.73
|
5.5 Persons
Standard Deviation 3.50
|
5.2 Persons
Standard Deviation 3.24
|
6.6 Persons
Standard Deviation 3.33
|
|
Mean Number of Subjects Living in the Same House at Survey 4
5-19Y, PLSPH
|
6.5 Persons
Standard Deviation 4.55
|
6.1 Persons
Standard Deviation 3.95
|
6.3 Persons
Standard Deviation 3.13
|
6.8 Persons
Standard Deviation 4.28
|
7.3 Persons
Standard Deviation 3.70
|
|
Mean Number of Subjects Living in the Same House at Survey 4
20+Y, PLSPH
|
5.0 Persons
Standard Deviation 2.94
|
6.3 Persons
Standard Deviation 2.22
|
—
|
5.0 Persons
Standard Deviation 0.00
|
6.6 Persons
Standard Deviation 3.96
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The malaria prevention and risk factors characteristics were the following: localisation categories (i.e.: rural, urban, semi-rural or missing) and Type of Location (i.e.: Large city: \>1 million habitants; Small city: \>50000 \& \< 1 million habitants; Town: \> 10000 and \< 50000 habitants; Countryside: \< 10000 habitants or missing type of location). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=786 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=258 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=81 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=188 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5088 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects by Localisation and Type of Location at Survey 1
6M-4Y, rural
|
309 Participants
|
136 Participants
|
45 Participants
|
106 Participants
|
1415 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 1
6M-4Y, urban
|
39 Participants
|
22 Participants
|
10 Participants
|
11 Participants
|
803 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 1
6M-4Y, semi-rural
|
25 Participants
|
12 Participants
|
3 Participants
|
2 Participants
|
262 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 1
6M-4Y, missing - localisation
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 1
6M-4Y, large city
|
18 Participants
|
14 Participants
|
7 Participants
|
7 Participants
|
355 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 1
6M-4Y, small city
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
18 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 1
6M-4Y, town
|
44 Participants
|
16 Participants
|
5 Participants
|
6 Participants
|
644 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 1
6M-4Y, countryside
|
311 Participants
|
140 Participants
|
46 Participants
|
106 Participants
|
1463 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 1
5-19Y, rural
|
225 Participants
|
55 Participants
|
16 Participants
|
51 Participants
|
688 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 1
5-19Y, urban
|
50 Participants
|
13 Participants
|
4 Participants
|
5 Participants
|
350 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 1
5-19Y, semi-rural
|
19 Participants
|
3 Participants
|
3 Participants
|
2 Participants
|
128 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 1
5-19Y, missing - localisation
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 1
5-19Y, large city
|
25 Participants
|
5 Participants
|
4 Participants
|
4 Participants
|
162 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 1
5-19Y, small city
|
1 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
7 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 1
5-19Y, town
|
43 Participants
|
11 Participants
|
2 Participants
|
3 Participants
|
282 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 1
5-19Y, countryside
|
225 Participants
|
55 Participants
|
17 Participants
|
51 Participants
|
715 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 1
5-19Y, missing - type of localisation
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 1
20+Y, rural
|
89 Participants
|
12 Participants
|
—
|
10 Participants
|
923 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 1
20+Y, urban
|
26 Participants
|
3 Participants
|
—
|
0 Participants
|
370 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 1
20+Y, semi-rural
|
4 Participants
|
2 Participants
|
—
|
1 Participants
|
147 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 1
20+Y, missing - localisation
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
1 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 1
20+Y, large city
|
16 Participants
|
3 Participants
|
—
|
0 Participants
|
181 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 1
20+Y, small city
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
9 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 1
20+Y, town
|
14 Participants
|
2 Participants
|
—
|
1 Participants
|
299 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 1
20+Y, countryside
|
89 Participants
|
12 Participants
|
—
|
10 Participants
|
951 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 1
20+Y, missing - type of localisation
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
1 Participants
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The malaria prevention and risk factors characteristics were the following: localisation categories (i.e.: rural, urban, semi-rural) and Type of Location (i.e.: Large city: \>1 million habitants; Small city: \>50000 \& \< 1 million habitants; Town: \> 10000 and \< 50000 habitants; Countryside: \< 10000 habitants). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=740 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=229 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=101 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=119 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5222 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects by Localisation and Type of Location at Survey 2
6M-4Y, large city
|
10 Participants
|
4 Participants
|
5 Participants
|
6 Participants
|
374 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 2
6M-4Y, rural
|
212 Participants
|
120 Participants
|
51 Participants
|
60 Participants
|
1377 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 2
6M-4Y, urban
|
44 Participants
|
16 Participants
|
14 Participants
|
15 Participants
|
995 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 2
6M-4Y, semi-rural
|
27 Participants
|
12 Participants
|
2 Participants
|
1 Participants
|
251 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 2
6M-4Y, small city
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
6 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 2
6M-4Y, town
|
34 Participants
|
12 Participants
|
9 Participants
|
9 Participants
|
632 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 2
6M-4Y, countryside
|
239 Participants
|
132 Participants
|
53 Participants
|
61 Participants
|
1611 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 2
5-19Y, rural
|
237 Participants
|
48 Participants
|
17 Participants
|
25 Participants
|
583 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 2
5-19Y, urban
|
72 Participants
|
22 Participants
|
11 Participants
|
10 Participants
|
472 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 2
5-19Y, semi-rural
|
24 Participants
|
1 Participants
|
1 Participants
|
1 Participants
|
103 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 2
5-19Y, large city
|
15 Participants
|
5 Participants
|
2 Participants
|
7 Participants
|
172 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 2
5-19Y, small city
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 2
5-19Y, town
|
57 Participants
|
17 Participants
|
9 Participants
|
3 Participants
|
305 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 2
5-19Y, countryside
|
261 Participants
|
49 Participants
|
18 Participants
|
26 Participants
|
680 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 2
20+Y, rural
|
94 Participants
|
6 Participants
|
2 Participants
|
6 Participants
|
769 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 2
20+Y, urban
|
26 Participants
|
4 Participants
|
3 Participants
|
1 Participants
|
515 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 2
20+Y, semi-rural
|
4 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
157 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 2
20+Y, large city
|
6 Participants
|
2 Participants
|
0 Participants
|
1 Participants
|
191 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 2
20+Y, small city
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
5 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 2
20+Y, town
|
20 Participants
|
2 Participants
|
3 Participants
|
0 Participants
|
330 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 2
20+Y, countryside
|
98 Participants
|
6 Participants
|
2 Participants
|
6 Participants
|
915 Participants
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The malaria prevention and risk factors characteristics were the following: localisation categories (i.e.: rural, urban, semi-rural) and Type of Location (i.e.: Large city: \>1 million habitants; Small city: \>50000 \& \< 1 million habitants; Town: \> 10000 and \< 50000 habitants; Countryside: \< 10000 habitants). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=791 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=268 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=92 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=130 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5119 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects by Localisation and Type of Location at Survey 3
6M-4Y, rural
|
234 Participants
|
146 Participants
|
65 Participants
|
82 Participants
|
1531 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 3
6M-4Y, urban
|
30 Participants
|
11 Participants
|
5 Participants
|
5 Participants
|
881 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 3
6M-4Y, semi-rural
|
15 Participants
|
4 Participants
|
4 Participants
|
4 Participants
|
176 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 3
6M-4Y, large city
|
7 Participants
|
3 Participants
|
1 Participants
|
3 Participants
|
386 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 3
6M-4Y, small city
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
2 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 3
6M-4Y, town
|
23 Participants
|
9 Participants
|
4 Participants
|
2 Participants
|
541 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 3
6M-4Y, countryside
|
249 Participants
|
149 Participants
|
69 Participants
|
86 Participants
|
1659 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 3
5-19Y, rural
|
283 Participants
|
78 Participants
|
9 Participants
|
28 Participants
|
645 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 3
5-19Y, urban
|
42 Participants
|
12 Participants
|
4 Participants
|
7 Participants
|
404 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 3
5-19Y, semi-rural
|
16 Participants
|
4 Participants
|
0 Participants
|
0 Participants
|
80 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 3
5-19Y, large city
|
12 Participants
|
2 Participants
|
2 Participants
|
2 Participants
|
182 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 3
5-19Y, small city
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 3
5-19Y, town
|
30 Participants
|
10 Participants
|
2 Participants
|
5 Participants
|
241 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 3
5-19Y, countryside
|
299 Participants
|
82 Participants
|
9 Participants
|
28 Participants
|
705 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 3
20+Y, rural
|
147 Participants
|
8 Participants
|
5 Participants
|
3 Participants
|
868 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 3
20+Y, urban
|
23 Participants
|
3 Participants
|
0 Participants
|
1 Participants
|
430 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 3
20+Y, semi-rural
|
1 Participants
|
2 Participants
|
0 Participants
|
0 Participants
|
104 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 3
20+Y, large city
|
15 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
185 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 3
20+Y, small city
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 3
20+Y, town
|
8 Participants
|
3 Participants
|
0 Participants
|
1 Participants
|
273 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 3
20+Y, countryside
|
148 Participants
|
10 Participants
|
5 Participants
|
3 Participants
|
943 Participants
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The malaria prevention and risk factors characteristics were the following: localisation categories (i.e.: rural, urban, semi-rural) and Type of Location (i.e.: Large city: \>1 million habitants; Small city: \>50000 \& \< 1 million habitants; Town: \> 10000 and \< 50000 habitants; Countryside: \< 10000 habitants). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=453 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=158 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=36 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=68 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=1684 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects by Localisation and Type of Location at Survey 4
20+Y, town
|
2 Participants
|
0 Participants
|
—
|
0 Participants
|
155 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 4
20+Y, countryside
|
85 Participants
|
4 Participants
|
—
|
1 Participants
|
353 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 4
6M-4Y, rural
|
153 Participants
|
102 Participants
|
20 Participants
|
53 Participants
|
536 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 4
6M-4Y, urban
|
15 Participants
|
1 Participants
|
0 Participants
|
1 Participants
|
312 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 4
6M-4Y, semi-rural
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 4
6M-4Y, large city
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 4
6M-4Y, small city
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 4
6M-4Y, town
|
15 Participants
|
1 Participants
|
0 Participants
|
1 Participants
|
311 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 4
6M-4Y, countryside
|
153 Participants
|
102 Participants
|
20 Participants
|
53 Participants
|
537 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 4
5-19Y, rural
|
184 Participants
|
49 Participants
|
14 Participants
|
11 Participants
|
186 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 4
5-19Y, urban
|
14 Participants
|
2 Participants
|
2 Participants
|
2 Participants
|
142 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 4
5-19Y, countryside
|
184 Participants
|
49 Participants
|
14 Participants
|
11 Participants
|
187 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 4
5-19Y, semi-rural
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 4
5-19Y, large city
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 4
5-19Y, small city
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 4
5-19Y, town
|
14 Participants
|
2 Participants
|
2 Participants
|
2 Participants
|
141 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 4
20+Y, rural
|
85 Participants
|
4 Participants
|
—
|
1 Participants
|
352 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 4
20+Y, urban
|
2 Participants
|
0 Participants
|
—
|
0 Participants
|
156 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 4
20+Y, semi-rural
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
0 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 4
20+Y, large city
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
0 Participants
|
|
Number of Subjects by Localisation and Type of Location at Survey 4
20+Y, small city
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
0 Participants
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The malaria prevention and risk factors characteristics were the following: Main house construction material (MHCM) walls and MHCM floor. MHCM walls data were assessed for the following sub-categories: mud, brick, cement/plaster, cement/paint, other and missing. MHCM floor data were assessed for the following sub-categories: natural floor, rudimentary floor, parquet polished wood, vinyl or asphalt strips, ceramic tiles, cement, carpet, missing. Note: Natural floor = earth, sand, dung; Rudimentary floor = wood planks, palm, bamboo. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=786 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=258 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=81 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=188 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5088 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
20+Y, MHCM floor - natural floor
|
64 Participants
|
5 Participants
|
—
|
8 Participants
|
690 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
20+Y, MHCM floor - rudimentary floor
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
2 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
20+Y, MHCM floor - ceramic tiles
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
13 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
20+Y, MHCM floor - missing
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
1 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
20+Y, MHCM walls - mud
|
43 Participants
|
7 Participants
|
—
|
9 Participants
|
548 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
20+Y, MHCM walls - brick
|
43 Participants
|
2 Participants
|
—
|
0 Participants
|
337 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
20+Y, MHCM walls - cement/plaster
|
12 Participants
|
5 Participants
|
—
|
1 Participants
|
192 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
20+Y, MHCM walls - missing
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
1 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
6M-4Y, MHCM walls - mud
|
97 Participants
|
62 Participants
|
34 Participants
|
84 Participants
|
869 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
6M-4Y, MHCM walls - brick
|
190 Participants
|
76 Participants
|
12 Participants
|
12 Participants
|
504 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
6M-4Y, MHCM walls - cement/plaster
|
41 Participants
|
16 Participants
|
7 Participants
|
11 Participants
|
383 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
6M-4Y, MHCM walls - cement/paint
|
29 Participants
|
12 Participants
|
5 Participants
|
11 Participants
|
408 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
20+Y, MHCM floor - parquet polished wood
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
1 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
6M-4Y, MHCM walls - other
|
16 Participants
|
4 Participants
|
0 Participants
|
1 Participants
|
316 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
20+Y, MHCM floor - vinyl/asphalt strips
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
2 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
6M-4Y, MHCM floor - natural floor
|
197 Participants
|
100 Participants
|
42 Participants
|
83 Participants
|
1079 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
6M-4Y, MHCM floor - rudimentary floor
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
3 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
6M-4Y, MHCM floor - parquet polished wood
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
2 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
6M-4Y, MHCM floor - vinyl/asphalt strips
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
4 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
6M-4Y, MHCM floor - ceramic tiles
|
0 Participants
|
1 Participants
|
0 Participants
|
0 Participants
|
30 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
6M-4Y, MHCM floor - cement
|
170 Participants
|
69 Participants
|
16 Participants
|
33 Participants
|
1309 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
20+Y, MHCM floor - cement
|
55 Participants
|
11 Participants
|
—
|
3 Participants
|
705 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
6M-4Y, MHCM floor - carpet
|
6 Participants
|
0 Participants
|
0 Participants
|
3 Participants
|
53 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
20+Y, MHCM floor - carpet
|
0 Participants
|
1 Participants
|
—
|
0 Participants
|
27 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
5-19Y, MHCM walls - mud
|
89 Participants
|
29 Participants
|
13 Participants
|
48 Participants
|
424 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
5-19Y, MHCM walls - brick
|
119 Participants
|
23 Participants
|
3 Participants
|
4 Participants
|
223 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
5-19Y, MHCM walls - cement/plaster
|
43 Participants
|
8 Participants
|
4 Participants
|
5 Participants
|
168 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
5-19Y, MHCM walls - cement/paint
|
30 Participants
|
4 Participants
|
3 Participants
|
1 Participants
|
186 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
5-19Y, MHCM walls - other
|
13 Participants
|
7 Participants
|
0 Participants
|
0 Participants
|
165 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
5-19Y, MHCM walls - missing
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
5-19Y, MHCM floor - natural floor
|
146 Participants
|
46 Participants
|
12 Participants
|
48 Participants
|
511 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
5-19Y, MHCM floor - rudimentary floor
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
5-19Y, MHCM floor - parquet polished wood
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
20+Y, MHCM walls - other
|
5 Participants
|
0 Participants
|
—
|
1 Participants
|
146 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
5-19Y, MHCM floor - vinyl/asphalt strips
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
2 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
5-19Y, MHCM floor - ceramic tiles
|
0 Participants
|
1 Participants
|
0 Participants
|
0 Participants
|
14 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
5-19Y, MHCM floor - cement
|
146 Participants
|
24 Participants
|
11 Participants
|
10 Participants
|
607 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
5-19Y, MHCM floor - carpet
|
2 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
30 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
5-19Y, MHCM floor - missing
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
20+Y, MHCM walls - cement/paint
|
16 Participants
|
3 Participants
|
—
|
0 Participants
|
217 Participants
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The malaria prevention and risk factors characteristics were the following: Main house construction material (MHCM) walls and MHCM floor. MHCM walls data were assessed for the following sub-categories: mud, brick, cement/plaster, cement/paint, other. MHCM floor data were assessed for the following sub-categories: natural floor, rudimentary floor, parquet polished wood, vinyl or asphalt strips, ceramic tiles, cement, carpet. Note: Natural floor = earth, sand, dung; Rudimentary floor = wood planks, palm, bamboo. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=740 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=229 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=101 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=119 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5222 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
6M-4Y, MHCM walls - mud
|
49 Participants
|
30 Participants
|
15 Participants
|
29 Participants
|
1010 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
6M-4Y, MHCM floor - ceramic tiles
|
0 Participants
|
1 Participants
|
0 Participants
|
1 Participants
|
40 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
6M-4Y, MHCM floor - cement
|
84 Participants
|
50 Participants
|
20 Participants
|
22 Participants
|
1357 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
5-19Y, MHCM walls - mud
|
79 Participants
|
20 Participants
|
11 Participants
|
21 Participants
|
445 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
5-19Y, MHCM walls - brick
|
155 Participants
|
26 Participants
|
11 Participants
|
7 Participants
|
191 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
5-19Y, MHCM walls - cement/plaster
|
51 Participants
|
15 Participants
|
2 Participants
|
4 Participants
|
207 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
5-19Y, MHCM walls - cement/paint
|
34 Participants
|
5 Participants
|
1 Participants
|
0 Participants
|
182 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
5-19Y, MHCM floor - rudimentary floor
|
1 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
5-19Y, MHCM floor - parquet polished wood
|
0 Participants
|
0 Participants
|
1 Participants
|
0 Participants
|
5 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
6M-4Y, MHCM floor - carpet
|
5 Participants
|
0 Participants
|
1 Participants
|
0 Participants
|
58 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
6M-4Y, MHCM walls - cement/plaster
|
33 Participants
|
14 Participants
|
8 Participants
|
8 Participants
|
472 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
6M-4Y, MHCM walls - cement/paint
|
32 Participants
|
15 Participants
|
4 Participants
|
2 Participants
|
393 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
6M-4Y, MHCM walls - other
|
6 Participants
|
8 Participants
|
6 Participants
|
6 Participants
|
290 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
6M-4Y, MHCM floor - natural floor
|
194 Participants
|
97 Participants
|
45 Participants
|
53 Participants
|
1145 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
6M-4Y, MHCM floor - rudimentary floor
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
2 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
6M-4Y, MHCM floor - parquet polished wood
|
0 Participants
|
0 Participants
|
1 Participants
|
0 Participants
|
6 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
6M-4Y, MHCM floor - vinyl/asphalt strips
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
15 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
6M-4Y, MHCM walls - brick
|
163 Participants
|
81 Participants
|
34 Participants
|
31 Participants
|
458 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
5-19Y, MHCM walls - other
|
14 Participants
|
5 Participants
|
4 Participants
|
4 Participants
|
133 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
5-19Y, MHCM floor - natural floor
|
207 Participants
|
42 Participants
|
17 Participants
|
26 Participants
|
508 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
5-19Y, MHCM floor - vinyl/asphalt strips
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
10 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
5-19Y, MHCM floor - ceramic tiles
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
26 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
5-19Y, MHCM floor - cement
|
117 Participants
|
29 Participants
|
11 Participants
|
9 Participants
|
587 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
5-19Y, MHCM floor - carpet
|
8 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
22 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
20+Y, MHCM walls - mud
|
26 Participants
|
5 Participants
|
1 Participants
|
5 Participants
|
520 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
20+Y, MHCM walls - brick
|
69 Participants
|
2 Participants
|
0 Participants
|
0 Participants
|
302 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
20+Y, MHCM walls - cement/plaster
|
7 Participants
|
0 Participants
|
1 Participants
|
1 Participants
|
258 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
20+Y, MHCM walls - cement/paint
|
15 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
215 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
20+Y, MHCM walls - other
|
7 Participants
|
3 Participants
|
3 Participants
|
1 Participants
|
146 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
20+Y, MHCM floor - natural floor
|
88 Participants
|
7 Participants
|
2 Participants
|
5 Participants
|
653 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
20+Y, MHCM floor - rudimentary floor
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
20+Y, MHCM floor - parquet polished wood
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
20+Y, MHCM floor - vinyl/asphalt strips
|
0 Participants
|
0 Participants
|
1 Participants
|
0 Participants
|
4 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
20+Y, MHCM floor - ceramic tiles
|
1 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
15 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
20+Y, MHCM floor - cement
|
34 Participants
|
3 Participants
|
2 Participants
|
2 Participants
|
732 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
20+Y, MHCM floor - carpet
|
1 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
35 Participants
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The malaria prevention and risk factors characteristics were the following: Main house construction material (MHCM) walls and MHCM floor. MHCM walls data were assessed for the following sub-categories: mud, brick, cement/plaster, cement/paint, other. MHCM floor data were assessed for the following sub-categories: natural floor, rudimentary floor, ceramic tiles, cement, carpet. Note: Natural floor = earth, sand, dung; Rudimentary floor = wood planks, palm, bamboo. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=791 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=268 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=92 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=130 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5119 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
6M-4Y, MHCM walls - mud
|
65 Participants
|
42 Participants
|
19 Participants
|
33 Participants
|
969 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
6M-4Y, MHCM walls - brick
|
143 Participants
|
91 Participants
|
41 Participants
|
43 Participants
|
485 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
6M-4Y, MHCM walls - cement/plaster
|
23 Participants
|
10 Participants
|
10 Participants
|
5 Participants
|
350 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
6M-4Y, MHCM walls - cement/paint
|
28 Participants
|
12 Participants
|
3 Participants
|
5 Participants
|
464 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
6M-4Y, MHCM walls - other
|
20 Participants
|
6 Participants
|
1 Participants
|
5 Participants
|
320 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
6M-4Y, MHCM floor - natural floor
|
188 Participants
|
111 Participants
|
54 Participants
|
65 Participants
|
1082 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
6M-4Y, MHCM floor - rudimentary floor
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
4 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
6M-4Y, MHCM floor - ceramic tiles
|
1 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
26 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
6M-4Y, MHCM floor - cement
|
85 Participants
|
49 Participants
|
20 Participants
|
25 Participants
|
1406 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
6M-4Y, MHCM floor - carpet
|
5 Participants
|
1 Participants
|
0 Participants
|
1 Participants
|
70 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
5-19Y, MHCM walls - mud
|
90 Participants
|
32 Participants
|
4 Participants
|
13 Participants
|
432 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
5-19Y, MHCM walls - brick
|
161 Participants
|
42 Participants
|
2 Participants
|
12 Participants
|
205 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
5-19Y, MHCM walls - cement/plaster
|
38 Participants
|
8 Participants
|
1 Participants
|
3 Participants
|
136 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
5-19Y, MHCM walls - cement/paint
|
41 Participants
|
5 Participants
|
2 Participants
|
2 Participants
|
214 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
5-19Y, MHCM walls - other
|
11 Participants
|
7 Participants
|
4 Participants
|
5 Participants
|
142 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
5-19Y, MHCM floor - natural floor
|
185 Participants
|
67 Participants
|
7 Participants
|
24 Participants
|
449 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
5-19Y, MHCM floor - rudimentary floor
|
0 Participants
|
1 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
5-19Y, MHCM floor - ceramic tiles
|
2 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
12 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
5-19Y, MHCM floor - cement
|
149 Participants
|
26 Participants
|
6 Participants
|
11 Participants
|
636 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
5-19Y, MHCM floor - carpet
|
5 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
32 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
20+Y, MHCM walls - mud
|
46 Participants
|
3 Participants
|
4 Participants
|
3 Participants
|
520 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
20+Y, MHCM walls - brick
|
90 Participants
|
4 Participants
|
0 Participants
|
0 Participants
|
298 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
20+Y, MHCM walls - cement/plaster
|
10 Participants
|
0 Participants
|
1 Participants
|
0 Participants
|
188 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
20+Y, MHCM walls - cement/paint
|
15 Participants
|
1 Participants
|
0 Participants
|
0 Participants
|
228 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
20+Y, MHCM walls - other
|
10 Participants
|
5 Participants
|
0 Participants
|
1 Participants
|
168 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
20+Y, MHCM floor - natural floor
|
124 Participants
|
9 Participants
|
4 Participants
|
3 Participants
|
651 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
20+Y, MHCM floor - rudimentary floor
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
2 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
20+Y, MHCM floor - ceramic tiles
|
0 Participants
|
1 Participants
|
0 Participants
|
0 Participants
|
12 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
20+Y, MHCM floor - cement
|
46 Participants
|
3 Participants
|
1 Participants
|
1 Participants
|
699 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
20+Y, MHCM floor - carpet
|
1 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
38 Participants
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The malaria prevention and risk factors characteristics were the following: Main house construction material (MHCM) walls and MHCM floor. MHCM walls data were assessed for the following sub-categories: mud, brick, cement/plaster, cement/paint, other. MHCM floor data were assessed for the following sub-categories: natural floor, rudimentary floor, vinyl or asphalt strips, ceramic tiles, cement, carpet. Note: Natural floor = earth, sand, dung; Rudimentary floor = wood planks, palm, bamboo. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=453 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=158 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=36 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=68 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=1684 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
5-19Y, MHCM floor - ceramic tiles
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
9 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
5-19Y, MHCM floor - carpet
|
4 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
8 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
6M-4Y, MHCM walls - mud
|
33 Participants
|
14 Participants
|
2 Participants
|
14 Participants
|
127 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
6M-4Y, MHCM walls - brick
|
92 Participants
|
76 Participants
|
17 Participants
|
33 Participants
|
231 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
6M-4Y, MHCM walls - cement/plaster
|
23 Participants
|
8 Participants
|
1 Participants
|
2 Participants
|
120 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
6M-4Y, MHCM walls - cement/paint
|
6 Participants
|
2 Participants
|
0 Participants
|
1 Participants
|
81 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
6M-4Y, MHCM walls - other
|
14 Participants
|
3 Participants
|
0 Participants
|
4 Participants
|
289 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
6M-4Y, MHCM floor - natural floor
|
97 Participants
|
76 Participants
|
15 Participants
|
37 Participants
|
267 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
6M-4Y, MHCM floor - rudimentary floor
|
0 Participants
|
1 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
6M-4Y, MHCM floor - vinyl/asphalt strips
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
2 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
6M-4Y, MHCM floor - ceramic tiles
|
0 Participants
|
1 Participants
|
0 Participants
|
0 Participants
|
16 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
6M-4Y, MHCM floor - cement
|
70 Participants
|
23 Participants
|
5 Participants
|
16 Participants
|
541 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
6M-4Y, MHCM floor - carpet
|
1 Participants
|
2 Participants
|
0 Participants
|
1 Participants
|
22 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
5-19Y, MHCM walls - mud
|
40 Participants
|
4 Participants
|
0 Participants
|
2 Participants
|
36 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
5-19Y, MHCM walls - brick
|
114 Participants
|
27 Participants
|
9 Participants
|
5 Participants
|
78 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
5-19Y, MHCM walls - cement/plaster
|
24 Participants
|
11 Participants
|
4 Participants
|
1 Participants
|
52 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
5-19Y, MHCM walls - cement/paint
|
13 Participants
|
4 Participants
|
1 Participants
|
0 Participants
|
30 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
5-19Y, MHCM walls - other
|
7 Participants
|
5 Participants
|
2 Participants
|
5 Participants
|
132 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
5-19Y, MHCM floor - natural floor
|
105 Participants
|
27 Participants
|
9 Participants
|
6 Participants
|
96 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
5-19Y, MHCM floor - rudimentary floor
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
20+Y, MHCM walls - other
|
3 Participants
|
1 Participants
|
—
|
0 Participants
|
153 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
5-19Y, MHCM floor - vinyl/asphalt strips
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
5-19Y, MHCM floor - cement
|
89 Participants
|
24 Participants
|
7 Participants
|
7 Participants
|
214 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
20+Y, MHCM walls - mud
|
18 Participants
|
0 Participants
|
—
|
1 Participants
|
76 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
20+Y, MHCM walls - brick
|
52 Participants
|
1 Participants
|
—
|
0 Participants
|
171 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
20+Y, MHCM walls - cement/plaster
|
13 Participants
|
2 Participants
|
—
|
0 Participants
|
70 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
20+Y, MHCM walls - cement/paint
|
1 Participants
|
0 Participants
|
—
|
0 Participants
|
38 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
20+Y, MHCM floor - natural floor
|
50 Participants
|
1 Participants
|
—
|
0 Participants
|
201 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
20+Y, MHCM floor - rudimentary floor
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
1 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
20+Y, MHCM floor - vinyl/asphalt strips
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
1 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
20+Y, MHCM floor - ceramic tiles
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
8 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
20+Y, MHCM floor - cement
|
37 Participants
|
3 Participants
|
—
|
1 Participants
|
287 Participants
|
|
Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
20+Y, MHCM floor - carpet
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
10 Participants
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The malaria prevention and risk factors characteristics were the following: main house construction material (MHCM) roof, windows/eaves, nets. MHCM roof data were assessed for the following sub-categories: grass/palm, iron sheet, tiles, other, missing. MHCM windows/eaves data were assessed for the following sub-categories: closed, open, partially open, missing. MHCM nets data were assessed for the following sub-categories: nets not present, nets present on all windows, nets present on some windows, missing. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=786 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=258 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=81 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=188 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5088 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
6M-4Y, MHCM, nets - present on all windows
|
26 Participants
|
6 Participants
|
1 Participants
|
21 Participants
|
450 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
6M-4Y, MHCM windows/eaves - open
|
76 Participants
|
33 Participants
|
17 Participants
|
20 Participants
|
486 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
6M-4Y, MHCM roof - grass/palm
|
112 Participants
|
53 Participants
|
22 Participants
|
44 Participants
|
453 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
6M-4Y, MHCM roof - iron sheet
|
231 Participants
|
109 Participants
|
35 Participants
|
74 Participants
|
1980 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
6M-4Y, MHCM roof - tiles
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
7 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
6M-4Y, MHCM roof - other
|
30 Participants
|
8 Participants
|
1 Participants
|
1 Participants
|
40 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
6M-4Y, MHCM windows/eaves - closed
|
193 Participants
|
93 Participants
|
31 Participants
|
77 Participants
|
1467 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
6M-4Y, MHCM windows/eaves - partially open
|
104 Participants
|
44 Participants
|
10 Participants
|
22 Participants
|
527 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
6M-4Y, MHCM windows/eaves - missing
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
6M-4Y, MHCM, nets - not present
|
322 Participants
|
157 Participants
|
54 Participants
|
91 Participants
|
1795 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
6M-4Y, MHCM, nets - present on some windows
|
25 Participants
|
7 Participants
|
3 Participants
|
7 Participants
|
235 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
5-19Y, MHCM roof - grass/palm
|
88 Participants
|
19 Participants
|
7 Participants
|
28 Participants
|
212 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
5-19Y, MHCM roof - iron sheet
|
193 Participants
|
48 Participants
|
16 Participants
|
30 Participants
|
944 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
5-19Y, MHCM roof - tiles
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
2 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
5-19Y, MHCM roof - other
|
13 Participants
|
4 Participants
|
0 Participants
|
0 Participants
|
8 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
5-19Y, MHCM roof - missing
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
5-19Y, MHCM windows/eaves - closed
|
154 Participants
|
44 Participants
|
14 Participants
|
38 Participants
|
669 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
5-19Y, MHCM windows/eaves - open
|
71 Participants
|
16 Participants
|
5 Participants
|
9 Participants
|
233 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
5-19Y, MHCM windows/eaves - partially open
|
69 Participants
|
11 Participants
|
4 Participants
|
11 Participants
|
264 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
5-19Y, MHCM windows/eaves - missing
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
5-19Y, MHCM, nets - not present
|
256 Participants
|
63 Participants
|
21 Participants
|
42 Participants
|
853 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
5-19Y, MHCM, nets - present on all windows
|
22 Participants
|
6 Participants
|
1 Participants
|
11 Participants
|
197 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
5-19Y, MHCM, nets - present on some windows
|
16 Participants
|
2 Participants
|
1 Participants
|
5 Participants
|
116 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
5-19Y, MHCM, nets - missing
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
20+Y, MHCM roof - grass/palm
|
31 Participants
|
5 Participants
|
—
|
3 Participants
|
280 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
20+Y, MHCM roof - iron sheet
|
84 Participants
|
12 Participants
|
—
|
8 Participants
|
1117 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
20+Y, MHCM roof - tiles
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
6 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
20+Y, MHCM roof - other
|
4 Participants
|
0 Participants
|
—
|
0 Participants
|
37 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
20+Y, MHCM roof - missing
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
1 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
20+Y, MHCM windows/eaves - closed
|
65 Participants
|
8 Participants
|
—
|
5 Participants
|
798 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
20+Y, MHCM windows/eaves - open
|
25 Participants
|
5 Participants
|
—
|
2 Participants
|
291 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
20+Y, MHCM windows/eaves - partially open
|
29 Participants
|
4 Participants
|
—
|
4 Participants
|
351 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
20+Y, MHCM windows/eaves - missing
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
1 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
20+Y, MHCM, nets - not present
|
107 Participants
|
12 Participants
|
—
|
7 Participants
|
1081 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
20+Y, MHCM, nets - present on all windows
|
8 Participants
|
3 Participants
|
—
|
2 Participants
|
223 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
20+Y, MHCM, nets - present on some windows
|
4 Participants
|
2 Participants
|
—
|
2 Participants
|
136 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
20+Y, MHCM, nets - missing
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
1 Participants
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The malaria prevention and risk factors characteristics were the following: main house construction material (MHCM) roof, windows/eaves, nets. MHCM roof data were assessed for the following sub-categories: grass/palm, iron sheet, tiles, other. MHCM windows/eaves data were assessed for the following sub-categories: closed, open, partially open. MHCM nets data were assessed for the following sub-categories: nets not present, nets present on all windows, nets present on some windows. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=740 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=229 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=101 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=119 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5222 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
6M-4Y, MHCM roof - grass/palm
|
52 Participants
|
32 Participants
|
16 Participants
|
23 Participants
|
509 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
6M-4Y, MHCM roof - iron sheet
|
201 Participants
|
102 Participants
|
46 Participants
|
50 Participants
|
2092 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
6M-4Y, MHCM roof - tiles
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
6M-4Y, MHCM roof - other
|
30 Participants
|
14 Participants
|
5 Participants
|
3 Participants
|
21 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
6M-4Y, MHCM windows/eaves - closed
|
97 Participants
|
54 Participants
|
30 Participants
|
39 Participants
|
1411 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
6M-4Y, MHCM windows/eaves - open
|
88 Participants
|
45 Participants
|
20 Participants
|
19 Participants
|
669 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
6M-4Y, MHCM windows/eaves - partially open
|
98 Participants
|
49 Participants
|
17 Participants
|
18 Participants
|
543 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
6M-4Y, MHCM, nets - not present
|
242 Participants
|
136 Participants
|
62 Participants
|
66 Participants
|
1843 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
6M-4Y, MHCM, nets - present on all windows
|
26 Participants
|
6 Participants
|
4 Participants
|
8 Participants
|
626 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
6M-4Y, MHCM, nets - present on some windows
|
15 Participants
|
6 Participants
|
1 Participants
|
2 Participants
|
154 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
5-19Y, MHCM roof - grass/palm
|
76 Participants
|
15 Participants
|
3 Participants
|
13 Participants
|
207 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
5-19Y, MHCM roof - iron sheet
|
241 Participants
|
54 Participants
|
26 Participants
|
23 Participants
|
940 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
5-19Y, MHCM roof - tiles
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
5-19Y, MHCM roof - other
|
16 Participants
|
2 Participants
|
0 Participants
|
0 Participants
|
11 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
5-19Y, MHCM windows/eaves - closed
|
159 Participants
|
36 Participants
|
16 Participants
|
14 Participants
|
610 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
5-19Y, MHCM windows/eaves - open
|
85 Participants
|
24 Participants
|
6 Participants
|
17 Participants
|
294 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
5-19Y, MHCM windows/eaves - partially open
|
89 Participants
|
11 Participants
|
7 Participants
|
5 Participants
|
254 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
5-19Y, MHCM, nets - not present
|
290 Participants
|
65 Participants
|
23 Participants
|
28 Participants
|
793 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
5-19Y, MHCM, nets - present on all windows
|
36 Participants
|
5 Participants
|
3 Participants
|
6 Participants
|
296 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
5-19Y, MHCM, nets - present on some windows
|
7 Participants
|
1 Participants
|
3 Participants
|
2 Participants
|
69 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
20+Y, MHCM roof - grass/palm
|
30 Participants
|
3 Participants
|
1 Participants
|
2 Participants
|
276 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
20+Y, MHCM roof - iron sheet
|
80 Participants
|
7 Participants
|
4 Participants
|
5 Participants
|
1144 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
20+Y, MHCM roof - tiles
|
1 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
2 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
20+Y, MHCM roof - other
|
13 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
19 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
20+Y, MHCM windows/eaves - closed
|
49 Participants
|
6 Participants
|
3 Participants
|
4 Participants
|
732 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
20+Y, MHCM windows/eaves - open
|
42 Participants
|
3 Participants
|
2 Participants
|
2 Participants
|
372 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
20+Y, MHCM windows/eaves - partially open
|
33 Participants
|
1 Participants
|
0 Participants
|
1 Participants
|
337 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
20+Y, MHCM, nets - not present
|
115 Participants
|
9 Participants
|
3 Participants
|
4 Participants
|
1033 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
20+Y, MHCM, nets - present on all windows
|
5 Participants
|
0 Participants
|
2 Participants
|
3 Participants
|
320 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
20+Y, MHCM, nets - present on some windows
|
4 Participants
|
1 Participants
|
0 Participants
|
0 Participants
|
88 Participants
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The malaria prevention and risk factors characteristics were the following: main house construction material (MHCM) roof, windows/eaves, nets. MHCM roof data were assessed for the following sub-categories: grass/palm, iron sheet, tiles, other. MHCM windows/eaves data were assessed for the following sub-categories: closed, open, partially open. MHCM nets data were assessed for the following sub-categories: nets not present, nets present on all windows, nets present on some windows. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=791 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=268 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=92 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=130 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5119 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
6M-4Y, MHCM roof - iron sheet
|
214 Participants
|
125 Participants
|
60 Participants
|
63 Participants
|
2111 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
5-19Y, MHCM roof - other
|
1 Participants
|
1 Participants
|
0 Participants
|
0 Participants
|
2 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
20+Y, MHCM windows/eaves - partially open
|
10 Participants
|
2 Participants
|
0 Participants
|
0 Participants
|
204 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
20+Y, MHCM, nets - not present
|
153 Participants
|
12 Participants
|
4 Participants
|
4 Participants
|
1052 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
20+Y, MHCM, nets - present on all windows
|
11 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
262 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
20+Y, MHCM, nets - present on some windows
|
7 Participants
|
1 Participants
|
1 Participants
|
0 Participants
|
88 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
6M-4Y, MHCM windows/eaves - partially open
|
29 Participants
|
12 Participants
|
8 Participants
|
4 Participants
|
391 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
6M-4Y, MHCM, nets - not present
|
244 Participants
|
149 Participants
|
63 Participants
|
84 Participants
|
1918 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
6M-4Y, MHCM, nets - present on all windows
|
21 Participants
|
10 Participants
|
6 Participants
|
4 Participants
|
532 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
6M-4Y, MHCM, nets - present on some windows
|
14 Participants
|
2 Participants
|
5 Participants
|
3 Participants
|
138 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
5-19Y, MHCM roof - grass/palm
|
76 Participants
|
16 Participants
|
1 Participants
|
5 Participants
|
186 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
5-19Y, MHCM roof - iron sheet
|
264 Participants
|
77 Participants
|
12 Participants
|
30 Participants
|
940 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
5-19Y, MHCM roof - tiles
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
5-19Y, MHCM windows/eaves - closed
|
165 Participants
|
58 Participants
|
9 Participants
|
18 Participants
|
593 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
5-19Y, MHCM windows/eaves - open
|
143 Participants
|
26 Participants
|
2 Participants
|
16 Participants
|
357 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
5-19Y, MHCM windows/eaves - partially open
|
33 Participants
|
10 Participants
|
2 Participants
|
1 Participants
|
179 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
5-19Y, MHCM, nets - not present
|
290 Participants
|
83 Participants
|
13 Participants
|
28 Participants
|
818 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
5-19Y, MHCM, nets - present on all windows
|
31 Participants
|
9 Participants
|
0 Participants
|
4 Participants
|
261 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
5-19Y, MHCM, nets - present on some windows
|
20 Participants
|
2 Participants
|
0 Participants
|
3 Participants
|
50 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
20+Y, MHCM roof - grass/palm
|
45 Participants
|
1 Participants
|
2 Participants
|
2 Participants
|
259 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
20+Y, MHCM roof - iron sheet
|
123 Participants
|
12 Participants
|
3 Participants
|
2 Participants
|
1123 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
20+Y, MHCM roof - tiles
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
9 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
20+Y, MHCM roof - other
|
3 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
11 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
20+Y, MHCM windows/eaves - closed
|
112 Participants
|
9 Participants
|
4 Participants
|
1 Participants
|
715 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
20+Y, MHCM windows/eaves - open
|
49 Participants
|
2 Participants
|
1 Participants
|
3 Participants
|
483 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
6M-4Y, MHCM roof - grass/palm
|
55 Participants
|
35 Participants
|
12 Participants
|
26 Participants
|
464 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
6M-4Y, MHCM roof - tiles
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
9 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
6M-4Y, MHCM roof - other
|
10 Participants
|
1 Participants
|
2 Participants
|
1 Participants
|
4 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
6M-4Y, MHCM windows/eaves - closed
|
164 Participants
|
82 Participants
|
38 Participants
|
57 Participants
|
1352 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
6M-4Y, MHCM windows/eaves - open
|
86 Participants
|
67 Participants
|
28 Participants
|
30 Participants
|
845 Participants
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The malaria prevention and risk factors characteristics were the following: main house construction material (MHCM) roof, windows/eaves, nets. MHCM roof data were assessed for the following sub-categories: grass/palm, iron sheet, other. MHCM windows/eaves data were assessed for the following sub-categories: closed, open, partially open. MHCM nets data were assessed for the following sub-categories: nets not present, nets present on all windows, nets present on some windows. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=453 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=158 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=36 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=68 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=1684 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
6M-4Y, MHCM roof - grass/palm
|
51 Participants
|
29 Participants
|
6 Participants
|
17 Participants
|
161 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
6M-4Y, MHCM roof - iron sheet
|
111 Participants
|
67 Participants
|
14 Participants
|
28 Participants
|
673 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
6M-4Y, MHCM windows/eaves - closed
|
124 Participants
|
58 Participants
|
13 Participants
|
34 Participants
|
725 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
6M-4Y, MHCM windows/eaves - open
|
15 Participants
|
13 Participants
|
1 Participants
|
5 Participants
|
66 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
6M-4Y, MHCM windows/eaves - partially open
|
29 Participants
|
32 Participants
|
6 Participants
|
15 Participants
|
57 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
6M-4Y, MHCM, nets - present on all windows
|
8 Participants
|
1 Participants
|
2 Participants
|
2 Participants
|
79 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
5-19Y, MHCM roof - grass/palm
|
55 Participants
|
10 Participants
|
1 Participants
|
2 Participants
|
51 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
5-19Y, MHCM roof - iron sheet
|
134 Participants
|
37 Participants
|
13 Participants
|
9 Participants
|
276 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
5-19Y, MHCM windows/eaves - closed
|
139 Participants
|
32 Participants
|
11 Participants
|
9 Participants
|
292 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
5-19Y, MHCM windows/eaves - open
|
24 Participants
|
8 Participants
|
4 Participants
|
1 Participants
|
17 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
5-19Y, MHCM windows/eaves - partially open
|
35 Participants
|
11 Participants
|
1 Participants
|
3 Participants
|
19 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
5-19Y, MHCM, nets - not present
|
162 Participants
|
41 Participants
|
14 Participants
|
13 Participants
|
276 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
5-19Y, MHCM, nets - present on some windows
|
19 Participants
|
5 Participants
|
0 Participants
|
0 Participants
|
27 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
20+Y, MHCM roof - grass/palm
|
27 Participants
|
0 Participants
|
—
|
1 Participants
|
98 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
20+Y, MHCM roof - other
|
4 Participants
|
0 Participants
|
—
|
1 Participants
|
16 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
20+Y, MHCM windows/eaves - closed
|
64 Participants
|
4 Participants
|
—
|
1 Participants
|
421 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
20+Y, MHCM windows/eaves - open
|
9 Participants
|
0 Participants
|
—
|
0 Participants
|
33 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
20+Y, MHCM windows/eaves - partially open
|
14 Participants
|
0 Participants
|
—
|
0 Participants
|
54 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
20+Y, MHCM, nets - not present
|
74 Participants
|
4 Participants
|
—
|
1 Participants
|
438 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
20+Y, MHCM, nets - present on all windows
|
7 Participants
|
0 Participants
|
—
|
0 Participants
|
32 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
6M-4Y, MHCM roof - other
|
6 Participants
|
7 Participants
|
0 Participants
|
9 Participants
|
14 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
6M-4Y, MHCM, nets - not present
|
156 Participants
|
95 Participants
|
16 Participants
|
51 Participants
|
712 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
6M-4Y, MHCM, nets - present on some windows
|
4 Participants
|
7 Participants
|
2 Participants
|
1 Participants
|
57 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
5-19Y, MHCM roof - other
|
9 Participants
|
4 Participants
|
2 Participants
|
2 Participants
|
1 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
5-19Y, MHCM, nets - present on all windows
|
17 Participants
|
5 Participants
|
2 Participants
|
0 Participants
|
25 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
20+Y, MHCM roof - iron sheet
|
56 Participants
|
4 Participants
|
—
|
0 Participants
|
394 Participants
|
|
Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
20+Y, MHCM, nets - present on some windows
|
6 Participants
|
0 Participants
|
—
|
0 Participants
|
38 Participants
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The malaria prevention and risk factors characteristics were the following: Main source of drinking water (MSDW): bottled water, closed water source (piped water, tube well, dug well, protected well), open water source (unprotected well, spring water, rainwater, tanker truck, surface water), missing; and Presence of electricity (PE): Yes, No, missing. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=786 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=258 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=81 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=188 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5088 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 1
5-19Y, MSDW - closed water source
|
182 Participants
|
41 Participants
|
13 Participants
|
19 Participants
|
767 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 1
6M-4Y, MSDW - bottled water
|
1 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
22 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 1
6M-4Y, MSDW - closed water source
|
246 Participants
|
111 Participants
|
28 Participants
|
49 Participants
|
1637 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 1
6M-4Y, MSDW - open water source
|
126 Participants
|
59 Participants
|
30 Participants
|
70 Participants
|
821 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 1
5-19Y, MSDW - open water source
|
111 Participants
|
30 Participants
|
10 Participants
|
39 Participants
|
390 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 1
5-19Y, MSDW - missing
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 1
5-19Y, PE - Yes
|
48 Participants
|
13 Participants
|
4 Participants
|
4 Participants
|
384 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 1
5-19Y, PE - No
|
246 Participants
|
58 Participants
|
19 Participants
|
54 Participants
|
782 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 1
5-19Y, PE - missing
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 1
20+Y, MSDW - bottled water
|
1 Participants
|
0 Participants
|
—
|
0 Participants
|
12 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 1
20+Y, MSDW - closed water source
|
82 Participants
|
10 Participants
|
—
|
4 Participants
|
943 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 1
20+Y, PE - No
|
101 Participants
|
12 Participants
|
—
|
10 Participants
|
1043 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 1
20+Y, PE - missing
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
1 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 1
6M-4Y, PE - Yes
|
66 Participants
|
24 Participants
|
7 Participants
|
13 Participants
|
780 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 1
6M-4Y, PE - No
|
307 Participants
|
146 Participants
|
51 Participants
|
106 Participants
|
1700 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 1
5-19Y, MSDW - bottled water
|
1 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
9 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 1
20+Y, MSDW - open water source
|
36 Participants
|
7 Participants
|
—
|
7 Participants
|
485 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 1
20+Y, MSDW - missing
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
1 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 1
20+Y, PE - Yes
|
18 Participants
|
5 Participants
|
—
|
1 Participants
|
397 Participants
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The malaria prevention and risk factors characteristics were the following: Main source of drinking water (MSDW): bottled water, closed water source (piped water, tube well, dug well, protected well), open water source (unprotected well, spring water, rainwater, tanker truck, surface water); and Presence of electricity (PE): Yes, No. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=740 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=229 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=101 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=119 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5222 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 2
6M-4Y, MSDW - bottled water
|
1 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
4 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 2
6M-4Y, MSDW - closed water source
|
207 Participants
|
93 Participants
|
44 Participants
|
42 Participants
|
1784 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 2
6M-4Y, MSDW - open water source
|
75 Participants
|
55 Participants
|
23 Participants
|
34 Participants
|
835 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 2
6M-4Y, PE - Yes
|
49 Participants
|
18 Participants
|
9 Participants
|
9 Participants
|
824 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 2
6M-4Y, PE - No
|
234 Participants
|
130 Participants
|
58 Participants
|
67 Participants
|
1799 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 2
5-19Y, MSDW - bottled water
|
1 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
3 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 2
5-19Y, MSDW - closed water source
|
229 Participants
|
45 Participants
|
22 Participants
|
21 Participants
|
760 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 2
5-19Y, PE - No
|
273 Participants
|
59 Participants
|
18 Participants
|
32 Participants
|
792 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 2
20+Y, MSDW - bottled water
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
4 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 2
20+Y, PE - Yes
|
23 Participants
|
4 Participants
|
2 Participants
|
1 Participants
|
436 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 2
5-19Y, MSDW - open water source
|
103 Participants
|
26 Participants
|
7 Participants
|
15 Participants
|
395 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 2
5-19Y, PE - Yes
|
60 Participants
|
12 Participants
|
11 Participants
|
4 Participants
|
366 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 2
20+Y, MSDW - closed water source
|
87 Participants
|
7 Participants
|
4 Participants
|
1 Participants
|
987 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 2
20+Y, MSDW - open water source
|
37 Participants
|
3 Participants
|
1 Participants
|
6 Participants
|
450 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 2
20+Y, PE - No
|
101 Participants
|
6 Participants
|
3 Participants
|
6 Participants
|
1005 Participants
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The malaria prevention and risk factors characteristics were the following: Main source of drinking water (MSDW): bottled water, closed water source (piped water, tube well, dug well, protected well), open water source (unprotected well, spring water, rainwater, tanker truck, surface water); and Presence of electricity (PE): Yes, No. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=791 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=268 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=92 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=130 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=5119 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 3
6M-4Y, MSDW - closed water source
|
185 Participants
|
97 Participants
|
37 Participants
|
53 Participants
|
1613 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 3
20+Y, MSDW - open water source
|
70 Participants
|
5 Participants
|
3 Participants
|
3 Participants
|
503 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 3
6M-4Y, MSDW - bottled water
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
26 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 3
6M-4Y, MSDW - open water source
|
94 Participants
|
64 Participants
|
37 Participants
|
37 Participants
|
949 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 3
6M-4Y, PE - Yes
|
36 Participants
|
25 Participants
|
8 Participants
|
11 Participants
|
775 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 3
6M-4Y, PE - No
|
243 Participants
|
136 Participants
|
66 Participants
|
80 Participants
|
1813 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 3
5-19Y, MSDW - bottled water
|
0 Participants
|
1 Participants
|
0 Participants
|
0 Participants
|
13 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 3
5-19Y, MSDW - closed water source
|
214 Participants
|
51 Participants
|
6 Participants
|
23 Participants
|
715 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 3
5-19Y, MSDW - open water source
|
127 Participants
|
42 Participants
|
7 Participants
|
12 Participants
|
401 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 3
5-19Y, PE - Yes
|
56 Participants
|
19 Participants
|
5 Participants
|
7 Participants
|
348 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 3
5-19Y, PE - No
|
285 Participants
|
75 Participants
|
8 Participants
|
28 Participants
|
781 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 3
20+Y, MSDW - bottled water
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
15 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 3
20+Y, MSDW - closed water source
|
101 Participants
|
8 Participants
|
2 Participants
|
1 Participants
|
884 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 3
20+Y, PE - Yes
|
19 Participants
|
3 Participants
|
0 Participants
|
1 Participants
|
386 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 3
20+Y, PE - No
|
152 Participants
|
10 Participants
|
5 Participants
|
3 Participants
|
1016 Participants
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The malaria prevention and risk factors characteristics were the following: Main source of drinking water (MSDW): bottled water, closed water source (piped water, tube well, dug well, protected well), open water source (unprotected well, spring water, rainwater, tanker truck, surface water); and Presence of electricity (PE): Yes, No. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=453 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=158 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=36 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=68 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
n=1684 Participants
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 4
6M-4Y, PE - No
|
148 Participants
|
98 Participants
|
20 Participants
|
51 Participants
|
464 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 4
5-19Y, MSDW - bottled water
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 4
6M-4Y, MSDW - bottled water
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
1 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 4
6M-4Y, MSDW - closed water source
|
139 Participants
|
79 Participants
|
15 Participants
|
38 Participants
|
656 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 4
6M-4Y, MSDW - open water source
|
29 Participants
|
24 Participants
|
5 Participants
|
16 Participants
|
191 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 4
6M-4Y, PE - Yes
|
20 Participants
|
5 Participants
|
0 Participants
|
3 Participants
|
384 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 4
5-19Y, MSDW - closed water source
|
155 Participants
|
38 Participants
|
12 Participants
|
9 Participants
|
247 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 4
5-19Y, MSDW - open water source
|
43 Participants
|
13 Participants
|
4 Participants
|
4 Participants
|
81 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 4
5-19Y, PE - Yes
|
23 Participants
|
8 Participants
|
3 Participants
|
4 Participants
|
161 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 4
5-19Y, PE - No
|
175 Participants
|
43 Participants
|
13 Participants
|
9 Participants
|
167 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 4
20+Y, MSDW - bottled water
|
0 Participants
|
0 Participants
|
—
|
0 Participants
|
1 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 4
20+Y, MSDW - closed water source
|
69 Participants
|
2 Participants
|
—
|
1 Participants
|
391 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 4
20+Y, MSDW - open water source
|
18 Participants
|
2 Participants
|
—
|
0 Participants
|
116 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 4
20+Y, PE - Yes
|
9 Participants
|
2 Participants
|
—
|
0 Participants
|
206 Participants
|
|
Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 4
20+Y, PE - No
|
78 Participants
|
2 Participants
|
—
|
1 Participants
|
302 Participants
|
SECONDARY outcome
Timeframe: At each Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
The malaria prevention measures (MPM) data were collected across centers from subjects with age between and including: 6M-4Y, 5-19 Y and 20Y+, for each Survey. The MPM results include the following categories: Use of Mosquito coils over 7 days (UMc \> 7D), Use of Insecticide spray over 7 days (UIs \> 7D), Use of Commercial Repellents over 7 days (UCR \> 7D), Use of Traditional Repellents over 7 days (UTR \> 7D), Use of none of above over 7 days (Una \>7D), Use of indoor residual spray in past 12 months to spray interior walls (Uirs past 12M), Use of indoor residual spray - number of months ago (Uirs-nM) or Use of indoor residual spray- no spray (Uirs-no spray): the number of months ago for each Uirs-nM sub-categories is defined using the following \[x Months\]. Not all Uirs-nM sub-categories were analyzed in each survey.
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=6401 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=6411 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=6400 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=2399 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[6M-4Y], Una >7D, Yes
|
2663 Participants
|
2726 Participants
|
2778 Participants
|
905 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[5-19Y], Una >7D, Missing/No
|
277 Participants
|
246 Participants
|
211 Participants
|
146 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[6M-4Y], Uirs past 12M, Yes
|
59 Participants
|
15 Participants
|
7 Participants
|
3 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[6M-4Y], UMc > 7D, Yes
|
433 Participants
|
398 Participants
|
348 Participants
|
239 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[6M-4Y], UMc > 7D, Missing/No
|
2767 Participants
|
2799 Participants
|
2845 Participants
|
954 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[6M-4Y], UIs > 7D, Yes
|
101 Participants
|
60 Participants
|
48 Participants
|
27 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[6M-4Y], UIs > 7D, Missing/No
|
3099 Participants
|
3137 Participants
|
3145 Participants
|
1166 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[6M-4Y], UCR > 7D, Yes
|
4 Participants
|
5 Participants
|
24 Participants
|
20 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[6M-4Y], UCR > 7D, Missing/No
|
3196 Participants
|
3192 Participants
|
3169 Participants
|
1173 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[6M-4Y], UTR > 7D, Yes
|
7 Participants
|
9 Participants
|
0 Participants
|
2 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[6M-4Y], UTR > 7D, Missing/No
|
3193 Participants
|
3188 Participants
|
3193 Participants
|
1191 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[6M-4Y], Una >7D, Missing/No
|
537 Participants
|
471 Participants
|
415 Participants
|
288 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[6M-4Y], Uirs past 12M, Missing/No
|
3141 Participants
|
3182 Participants
|
3186 Participants
|
1190 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[6M-4Y], Uirs-nM [1 Month]
|
9 Participants
|
1 Participants
|
1 Participants
|
0 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[6M-4Y], Uirs-nM [11 Months]
|
—
|
—
|
1 Participants
|
—
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[6M-4Y], Uirs-nM [12 Months]
|
5 Participants
|
1 Participants
|
2 Participants
|
—
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[6M-4Y], Uirs-nM [10 Months]
|
—
|
—
|
—
|
1 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[6M-4Y], Uirs-nM [2 Months]
|
6 Participants
|
3 Participants
|
—
|
1 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[6M-4Y], Uirs-nM [3 Months]
|
21 Participants
|
5 Participants
|
3 Participants
|
1 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[6M-4Y], Uirs-nM [4 Months]
|
9 Participants
|
2 Participants
|
1 Participants
|
—
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[6M-4Y], Uirs-nM [5 Months]
|
1 Participants
|
2 Participants
|
—
|
—
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[6M-4Y], Uirs-nM [6 Months]
|
6 Participants
|
—
|
—
|
—
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[6M-4Y], Uirs-nM [7 Months]
|
1 Participants
|
1 Participants
|
—
|
—
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[6M-4Y], Uirs-nM [9 Months]
|
1 Participants
|
—
|
—
|
—
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[6M-4Y], Uirs-nM [no spray]
|
3141 Participants
|
3182 Participants
|
3186 Participants
|
1190 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[5-19Y], UMc > 7D, Yes
|
227 Participants
|
209 Participants
|
180 Participants
|
127 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[5-19Y], UMc > 7D, Missing/No
|
1386 Participants
|
1418 Participants
|
1432 Participants
|
479 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[5-19Y], UIs > 7D, Yes
|
45 Participants
|
32 Participants
|
20 Participants
|
10 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[5-19Y], UIs > 7D, Missing/No
|
1568 Participants
|
1595 Participants
|
1592 Participants
|
596 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[5-19Y], UCR > 7D, Yes
|
4 Participants
|
2 Participants
|
12 Participants
|
7 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[5-19Y], UCR > 7D, Missing/No
|
1609 Participants
|
1625 Participants
|
1600 Participants
|
599 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[5-19Y], UTR > 7D, Yes
|
3 Participants
|
3 Participants
|
0 Participants
|
2 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[5-19Y], UTR > 7D, Missing/No
|
1610 Participants
|
1624 Participants
|
1612 Participants
|
604 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[5-19Y], Una >7D, Yes
|
1336 Participants
|
1381 Participants
|
1401 Participants
|
460 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[5-19Y], Uirs past 12M, Yes
|
24 Participants
|
8 Participants
|
3 Participants
|
1 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[5-19Y], Uirs past 12M, Missing/No
|
1589 Participants
|
1619 Participants
|
1609 Participants
|
605 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[5-19Y], Uirs-nM [1 Month]
|
2 Participants
|
1 Participants
|
—
|
1 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[5-19Y], Uirs-nM [11 Months]
|
—
|
—
|
1 Participants
|
—
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[5-19Y], Uirs-nM [12 Months]
|
2 Participants
|
1 Participants
|
1 Participants
|
—
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[5-19Y], Uirs-nM [2 Months]
|
1 Participants
|
2 Participants
|
—
|
0 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[5-19Y], Uirs-nM [3 Months]
|
13 Participants
|
3 Participants
|
0 Participants
|
0 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[5-19Y], Uirs-nM [4 Months]
|
2 Participants
|
0 Participants
|
1 Participants
|
—
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[5-19Y], Uirs-nM [5 Months]
|
0 Participants
|
1 Participants
|
—
|
—
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[5-19Y], Uirs-nM [6 Months]
|
4 Participants
|
—
|
—
|
—
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[5-19Y], Uirs-nM [7 Months]
|
0 Participants
|
0 Participants
|
—
|
—
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[5-19Y], Uirs-nM [9 Months]
|
0 Participants
|
—
|
—
|
—
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[5-19Y], Uirs-nM [no spray]
|
1589 Participants
|
1619 Participants
|
1609 Participants
|
605 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[Y20+], UMc > 7D, Yes
|
196 Participants
|
199 Participants
|
167 Participants
|
117 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[Y20+], UMc > 7D, Missing/No
|
1392 Participants
|
1388 Participants
|
1428 Participants
|
483 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[Y20+], UIs > 7D, Yes
|
46 Participants
|
30 Participants
|
28 Participants
|
11 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[Y20+], UIs > 7D, Missing/No
|
1542 Participants
|
1557 Participants
|
1567 Participants
|
589 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[Y20+], UCR > 7D, Yes
|
0 Participants
|
4 Participants
|
12 Participants
|
12 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[Y20+], UCR > 7D, Missing/No
|
1588 Participants
|
1583 Participants
|
1583 Participants
|
588 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[Y20+], UTR > 7D, Yes
|
4 Participants
|
4 Participants
|
0 Participants
|
0 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[Y20+], UTR > 7D, Missing/No
|
1584 Participants
|
1583 Participants
|
1595 Participants
|
600 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[Y20+], Una >7D, Yes
|
1346 Participants
|
1350 Participants
|
1392 Participants
|
460 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[Y20+], Una >7D, Missing/No
|
242 Participants
|
237 Participants
|
203 Participants
|
140 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[Y20+], Uirs past 12M, Yes
|
32 Participants
|
7 Participants
|
2 Participants
|
2 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[Y20+], Uirs past 12M, Missing/No
|
1556 Participants
|
1580 Participants
|
1593 Participants
|
598 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[Y20+], Uirs-nM [1 Month]
|
7 Participants
|
0 Participants
|
—
|
0 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[Y20+], Uirs-nM [11 Months]
|
—
|
—
|
0 Participants
|
—
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[Y20+], Uirs-nM [12 Months]
|
3 Participants
|
0 Participants
|
1 Participants
|
—
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[Y20+], Uirs-nM [10 Months]
|
—
|
—
|
—
|
1 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[Y20+], Uirs-nM [2 Months]
|
4 Participants
|
1 Participants
|
—
|
1 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[Y20+], Uirs-nM [3 Months]
|
8 Participants
|
3 Participants
|
1 Participants
|
0 Participants
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[Y20+], Uirs-nM [4 Months]
|
6 Participants
|
2 Participants
|
0 Participants
|
—
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[Y20+], Uirs-nM [5 Months]
|
1 Participants
|
1 Participants
|
—
|
—
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[Y20+], Uirs-nM [6 Months]
|
2 Participants
|
—
|
—
|
—
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[Y20+], Uirs-nM [7 Months]
|
1 Participants
|
0 Participants
|
—
|
—
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[Y20+], Uirs-nM [9 Months]
|
0 Participants
|
—
|
—
|
—
|
—
|
|
Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
[Y20+], Uirs-nM [no spray]
|
1556 Participants
|
1580 Participants
|
1593 Participants
|
598 Participants
|
—
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
Data were collected across centers from subjects with age between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. The other Plasmodium species assessed were: P. Malaria, P. Vivax, P. Ovale. Infection were determined using a blood smear slide, and categorized according positive (Pos) and negative (Neg) results.
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=3200 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=1613 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=1588 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 1
P.Malariae, Pos
|
19 Participants
|
21 Participants
|
1 Participants
|
—
|
—
|
|
Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 1
P.Malariae, Neg
|
3181 Participants
|
1592 Participants
|
1587 Participants
|
—
|
—
|
|
Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 1
P.Vivax, Pos
|
0 Participants
|
0 Participants
|
0 Participants
|
—
|
—
|
|
Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 1
P.Vivax, Neg
|
3200 Participants
|
1613 Participants
|
1588 Participants
|
—
|
—
|
|
Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 1
P.Ovale, Pos
|
3 Participants
|
1 Participants
|
0 Participants
|
—
|
—
|
|
Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 1
P.Ovale, Neg
|
3197 Participants
|
1612 Participants
|
1588 Participants
|
—
|
—
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
Data were collected across centers from subjects with age between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. The other Plasmodium species assessed were: P. Malaria, P. Vivax, P. Ovale. Infection were determined using a blood smear slide, and categorized according positive (Pos) and negative (Neg) results.
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=3197 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=1627 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=1587 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 2
P.Ovale, Pos
|
6 Participants
|
3 Participants
|
2 Participants
|
—
|
—
|
|
Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 2
P.Ovale, Neg
|
3191 Participants
|
1624 Participants
|
1585 Participants
|
—
|
—
|
|
Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 2
P.Malariae, Pos
|
32 Participants
|
27 Participants
|
2 Participants
|
—
|
—
|
|
Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 2
P.Malariae, Neg
|
3165 Participants
|
1600 Participants
|
1585 Participants
|
—
|
—
|
|
Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 2
P.Vivax, Pos
|
0 Participants
|
0 Participants
|
0 Participants
|
—
|
—
|
|
Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 2
P.Vivax, Neg
|
3197 Participants
|
1627 Participants
|
1587 Participants
|
—
|
—
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
Data were collected across centers from subjects with age between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. The other Plasmodium species assessed were: P. Malaria, P. Vivax, P. Ovale. Infection were determined using a blood smear slide, and categorized according positive (Pos) and negative (Neg) results.
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=3193 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=1612 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=1595 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 3
P.Malariae, Pos
|
48 Participants
|
27 Participants
|
0 Participants
|
—
|
—
|
|
Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 3
P.Malariae, Neg
|
3145 Participants
|
1585 Participants
|
1595 Participants
|
—
|
—
|
|
Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 3
P.Vivax, Pos
|
0 Participants
|
0 Participants
|
0 Participants
|
—
|
—
|
|
Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 3
P.Vivax, Neg
|
3193 Participants
|
1612 Participants
|
1595 Participants
|
—
|
—
|
|
Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 3
P.Ovale, Pos
|
6 Participants
|
4 Participants
|
1 Participants
|
—
|
—
|
|
Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 3
P.Ovale, Neg
|
3187 Participants
|
1608 Participants
|
1594 Participants
|
—
|
—
|
SECONDARY outcome
Timeframe: At Survey visitPopulation: Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.
Data were collected across centers from subjects with age between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. The other Plasmodium species assessed were: P. Malaria, P. Vivax, P. Ovale. Infection were determined using a blood smear slide, and categorized according positive (Pos) and negative (Neg) results.
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=1193 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=606 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=600 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 4
P.Malariae, Pos
|
32 Participants
|
28 Participants
|
0 Participants
|
—
|
—
|
|
Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 4
P.Malariae, Neg
|
1161 Participants
|
578 Participants
|
600 Participants
|
—
|
—
|
|
Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 4
P.Vivax, Pos
|
0 Participants
|
0 Participants
|
0 Participants
|
—
|
—
|
|
Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 4
P.Vivax, Neg
|
1193 Participants
|
606 Participants
|
600 Participants
|
—
|
—
|
|
Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 4
P.Ovale, Pos
|
3 Participants
|
3 Participants
|
1 Participants
|
—
|
—
|
|
Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 4
P.Ovale, Neg
|
1190 Participants
|
603 Participants
|
599 Participants
|
—
|
—
|
SECONDARY outcome
Timeframe: At each Survey visitPopulation: The analysis was performed on the Total cohort, which included all subjects enrolled in the study.
Serious adverse events (SAEs) assessed include medical occurrences that result in death, are life threatening, require hospitalization or prolongation of hospitalization or result in disability/incapacity. Capillary blood sampling was the only invasive procedure involved in this study. SAEs related to this procedure were recorded at the Survey visit.
Outcome measures
| Measure |
Overall Study Group (Survey 1)
n=6404 Participants
Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 2)
n=6414 Participants
Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 3)
n=6400 Participants
Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Overall Study Group (Survey 4)
n=2400 Participants
Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
|
Neg PD Group (Survey 1)
Subjects from Survey 1 not infected with P.falciparum.
|
|---|---|---|---|---|---|
|
Number of Subjects With Serious Adverse Events (SAEs) Related to Study Procedure for Each Survey
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
—
|
Adverse Events
Overall Study Group (Survey 1)
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Overall Study Group (Survey 2)
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Overall Study Group (Survey 3)
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Overall Study Group (Survey 4)
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee GSK agreements may vary with individual investigators, but will not prohibit any investigator from publishing. GSK supports the publication of results from all centers of a multi-center trial but requests that reports based on single-site data not precede the primary publication of the entire clinical trial.
- Publication restrictions are in place
Restriction type: OTHER