Chronic Muscle Disuse in the Elderly

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

35 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-10-31

Study Completion Date

2016-06-30

Brief Summary

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The purpose of this study is to define the effects of chronic disuse on skeletal muscle structure and function in elderly individuals at the cellular and molecular level by examining elderly characterized by chronic muscle disuse (patients with knee osteoarthritis) and healthy elderly no evidence of knee osteoarthritis and normal physical activity levels.

Detailed Description

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Skeletal muscle disuse is an important contributing factor to physical disability. Disuse is more frequent in the elderly and they are more susceptible to its debilitating effects because of their diminished physiological reserve. Despite these facts, the mechanisms whereby disuse promotes skeletal muscle contractile dysfunction in this population remain largely undetermined. Therefore, the investigators will systematically test for modifications of single skeletal muscle fiber structure and function that underlie contractile dysfunction. Elderly individuals characterized by chronic muscle disuse (patients with knee osteoarthritis) will be compared to carefully-matched controls with no clinical evidence of knee osteoarthritis and normal activity levels. Thereafter, elderly with chronic disuse will undergo an exercise intervention to remediate muscle disuse. The investigators hypothesize that muscle disuse impairs contractile function, in part, through alterations in myosin kinetics, myofilament protein content and the mechanical properties of the myofilament lattice and that exercise rehabilitation will counteract these deficits. The investigators will specifically examine the effect of disuse on mechanical, kinetic and structural properties and molecular composition of single muscle fibers in cases and controls, as well as determine how increasing muscle use in elderly with chronic disuse via exercise training affects muscle fiber mechanical, kinetic and structural properties and molecular composition. These translational studies will provide the first comprehensive evaluation of the cellular and molecular mechanisms through which muscle disuse alters skeletal muscle structure and contractile function in elderly humans. This knowledge can assist in the development and refinement of preventative and corrective therapies for disability by tailoring these approaches to address specific molecular defects.

Conditions

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Osteoarthritis

Keywords

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elderly muscle disuse osteoarthritis exercise

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Resistance exercise training

Exercise is being used as an experimental tool to determine if remediation of muscle disuse counteracts cellular/molecular defects in muscle structure/function.

Group Type OTHER

Resistance exercise training

Intervention Type BEHAVIORAL

Lower extremity resistance exercise training 3x/wk

Interventions

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Resistance exercise training

Lower extremity resistance exercise training 3x/wk

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* 60-80 yrs of age
* physician-diagnosed, symptomatic knee osteoarthritis
* ambulatory and able to perform lower extremity resistance exercise

Exclusion Criteria

* rheumatoid arthritis or other autoimmune disease
* chronic heart, lung, kidney or liver disease or hypertension
* diabetes
* history of stroke
* other neurological or musculoskeletal disease

HEALTHY CONTROLS

Criteria are identical to those for knee osteoarthritis patients above, but controls will have no clinical or radiographic evidence of osteoarthritis and will have normal activity physical activity levels.

Minimum Eligible Age

60 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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Michael J. Toth, Ph.D.

Associate Professor of Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Michael J. Toth, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of Vermont and State Agricultural College

Locations

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University of Vermont and State Agricultural College

Burlington, Vermont, United States

Site Status

Countries

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United States

Reference Type DERIVED

PMID: 31533814 (View on PubMed)

Other Identifiers

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R01AG033547

Identifier Type: NIH

Identifier Source: secondary_id

View Link

033547

Identifier Type: -

Identifier Source: org_study_id

Chronic Muscle Disuse in the Elderly

Study Results

Basic Information

Brief Summary

Detailed Description

Conditions

Keywords

Study Design

Study Groups

Resistance exercise training

Resistance exercise training

Interventions

Resistance exercise training

Eligibility Criteria

Inclusion Criteria

Exclusion Criteria

Sponsors

National Institute on Aging (NIA)

University of Vermont

Responsible Party

Michael J. Toth, Ph.D.

Principal Investigators

Michael J. Toth, Ph.D.

Locations

University of Vermont and State Agricultural College

Countries

References

Gustavson AM, Wolfe P, Falvey JR, Eckhoff DG, Toth MJ, Stevens-Lapsley JE. Men and Women Demonstrate Differences in Early Functional Recovery After Total Knee Arthroplasty. Arch Phys Med Rehabil. 2016 Jul;97(7):1154-62. doi: 10.1016/j.apmr.2016.03.007. Epub 2016 Apr 8.

Rengo JL, Callahan DM, Savage PD, Ades PA, Toth MJ. Skeletal muscle ultrastructure and function in statin-tolerant individuals. Muscle Nerve. 2016 Feb;53(2):242-51. doi: 10.1002/mus.24722. Epub 2015 Dec 9.

Miller MS, Bedrin NG, Ades PA, Palmer BM, Toth MJ. Molecular determinants of force production in human skeletal muscle fibers: effects of myosin isoform expression and cross-sectional area. Am J Physiol Cell Physiol. 2015 Mar 15;308(6):C473-84. doi: 10.1152/ajpcell.00158.2014. Epub 2015 Jan 7.

Miller MS, Callahan DM, Toth MJ. Skeletal muscle myofilament adaptations to aging, disease, and disuse and their effects on whole muscle performance in older adult humans. Front Physiol. 2014 Sep 26;5:369. doi: 10.3389/fphys.2014.00369. eCollection 2014.

Other Identifiers

R01AG033547

033547