Australian Clinical Study of the Apnex Medical HGNS System to Treat Obstructive Sleep Apnea

NCT ID: NCT01186926

Last Updated: 2015-04-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2/PHASE3

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-03-31

Study Completion Date

2013-05-31

Brief Summary

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The overall goal of the study is to evaluate the safety, efficacy and therapy settings of the HGNS System for stimulating the hypoglossal nerve to help maintain an open airway in subjects with obstructive sleep apnea (OSA).

Detailed Description

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Conditions

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Obstructive Sleep Apnea

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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HGNS Treatment

Group Type EXPERIMENTAL

HGNS Treatment

Intervention Type DEVICE

The Apnex Hypoglossal Nerve Stimulation (HGNS) System is an implanted medical device that is designed to prevent the tongue from blocking the airway during sleep. It is fully automatic and can be implanted during a simple surgical procedure. After it is implanted, the device is programmed to meet the unique needs of each patient. The device is on when the patient is sleeping, and off when the patient is awake.

Interventions

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HGNS Treatment

The Apnex Hypoglossal Nerve Stimulation (HGNS) System is an implanted medical device that is designed to prevent the tongue from blocking the airway during sleep. It is fully automatic and can be implanted during a simple surgical procedure. After it is implanted, the device is programmed to meet the unique needs of each patient. The device is on when the patient is sleeping, and off when the patient is awake.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

Eligibility Criteria

1. Previously diagnosed with moderate to severe obstructive sleep apnea.
2. Subject has failed or does not tolerate CPAP treatment.
3. Age between 21 and 70 years.
4. Body mass index (BMI) less than or equal to 40
Minimum Eligible Age

21 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Apnex Medical, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Maree Barnes, MD

Role: PRINCIPAL_INVESTIGATOR

Institute for Breathing and Sleep, Austin Health

David Hillman, MD

Role: PRINCIPAL_INVESTIGATOR

West Australian Sleep Disorders Research Institute, St. Charles Gardner Hospital

Doug McEvoy, MD

Role: PRINCIPAL_INVESTIGATOR

Adelaide Institute for Sleep Health, Repatriation General Hospital

John Wheatley, MD

Role: PRINCIPAL_INVESTIGATOR

Westmead Hospital Dept of Respiratory Medicine

References

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Eastwood PR, Barnes M, Walsh JH, Maddison KJ, Hee G, Schwartz AR, Smith PL, Malhotra A, McEvoy RD, Wheatley JR, O'Donoghue FJ, Rochford PD, Churchward T, Campbell MC, Palme CE, Robinson S, Goding GS, Eckert DJ, Jordan AS, Catcheside PG, Tyler L, Antic NA, Worsnop CJ, Kezirian EJ, Hillman DR. Treating obstructive sleep apnea with hypoglossal nerve stimulation. Sleep. 2011 Nov 1;34(11):1479-86. doi: 10.5665/sleep.1380.

Reference Type RESULT
PMID: 22043118 (View on PubMed)

Other Identifiers

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CLP-003

Identifier Type: -

Identifier Source: org_study_id

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