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Neurophysiological Reserve With Caffeine Manipulation

NCT ID: NCT01167478

Last Updated: 2014-12-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-03-31

Study Completion Date

2011-09-30

Brief Summary

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The objective of this study is to verify if there is a neurophysiologic reserve when caffeine and placebo perceived as caffeine are manipulated in closed- and opened-loop exercises. Parameters of excitability level of skeletal muscle and Central Nervous System (CNS), and peripheral metabolism will be measured

Detailed Description

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A neurophysiological reserve related to central mechanisms is supposed to be present, which should be observed when an increased central drive occurs. In theory, according to the central regulation model of effort, an increased performance could be due to the elevation on Central Nervous System excitability and activity, since exercise is not peripherally limited. Conversely, the absence of muscle performance improvement to the increased central drive promoted by caffeine would be an evidence for a peripherally localized neurophysiological limit and would indicate the absence of reserve. Therefore, if present, this reserve could be verified by using peripheral and central measures derived from electric-stimulation, evoked twitch and interpolated twitch techniques, associated to measures of EMG and peripheral metabolism, when caffeine is manipulated during closed- and opened-loop exercise.

In addition, there should also be possible to access the reserve without stimulant substance manipulation (placebo effect). By teleological argument derived from the central regulation model of effort, a neurophysiological reserve would be a natural mechanism to protect the cellular integrity. Therefore, it would be reasonable to hypothesize that, if present, a reserve would be observed by an increase in performance promoted by an elevation in central drive when placebo is perceived as caffeine. Unfortunately, however, no study utilized this experimental approach, including measures of central and peripheral activity during closed- and opened-loop exercise, to consistently respond the reserve question.

Conditions

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Caffeine Placebo

Keywords

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Exercise Caffeine Reserve

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Caffeine

Group Type EXPERIMENTAL

Caffeine

Intervention Type DIETARY_SUPPLEMENT

After ingestion of 6 mg.kg-1 of body mass of caffeine, subjects will perform the one exercise trial.

Caffeine

Intervention Type DIETARY_SUPPLEMENT

6 mg/kg of body mass of caffeine will be ingested by subjects before exercise.

Interventions

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Caffeine

After ingestion of 6 mg.kg-1 of body mass of caffeine, subjects will perform the one exercise trial.

Intervention Type DIETARY_SUPPLEMENT

Caffeine

6 mg/kg of body mass of caffeine will be ingested by subjects before exercise.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* trained cyclists
* trained in long distance races

Exclusion Criteria

* Maximum oxygen uptake lower than 55 ml/kg/min
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Fundação de Amparo à Pesquisa do Estado de São Paulo

OTHER_GOV

Sponsor Role collaborator

University of Sao Paulo

OTHER

Sponsor Role lead

Responsible Party

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Flavio de Oliveira Pires

Post-doctoral

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Carlos Ugrinowitsch, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Sao Paulo

Locations

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University of São Paulo

São Paulo, São Paulo, Brazil

Site Status

Countries

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Brazil

References

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Lambert EV, St Clair Gibson A, Noakes TD. Complex systems model of fatigue: integrative homoeostatic control of peripheral physiological systems during exercise in humans. Br J Sports Med. 2005 Jan;39(1):52-62. doi: 10.1136/bjsm.2003.011247.

Reference Type BACKGROUND
PMID: 15618343 (View on PubMed)

Other Identifiers

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2010/01317-0

Identifier Type: -

Identifier Source: secondary_id

EEFE026

Identifier Type: -

Identifier Source: org_study_id