Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
122 participants
OBSERVATIONAL
2010-01-31
2010-07-31
Brief Summary
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Extreme low birth weight infants (ELBW, birth weight \< 1000 g) are at increased risk for development of PNAC.
Important factors implicated in the aetiology of PNAC are high caloric parenteral nutrition using amino acids or dextrose, but also intravenous lipids and infections in particular necrotizing enterocolitis (NEC).
Due to a change of paradigm a more aggressive nutrition with early use of parenteral amino acids/lipids and early fortification of mothers milk or alternatively high caloric preterm formula is warranted. Accordingly - in line with the existing expert opinion and evidence - the feeding policy at the neonatal care units of our hospital was adapted.
Evidence exists that PNAC might be caused by the use of high concentrations of amino acids and lipids in parenteral nutrition. Furthermore NEC is associated with high osmotic feeds. Therefore the incidence of PNAC might be increased directly and indirectly after introducing the new feeding policy.
The investigators therefore aim at retrospectively investigating the incidence of PNAC before and after introduction of a feeding policy of "aggressive nutrition" for ELBW infants.
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Detailed Description
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Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Before
ELBW infants before change of feeding policy
No interventions assigned to this group
After
ELBW infants after change of feeding policy
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Born in house between January 2005 - December 2006 ("before") and July 2007- June 2009 ("after")
Exclusion Criteria
* Death or transfer before 28 Days of life
* Diseases associated with Cholestasis
1 Hour
ALL
No
Sponsors
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Medical University of Vienna
OTHER
Responsible Party
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Nadja Haiden,MD
PD Dr.
Principal Investigators
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Nadja Haiden, MD
Role: PRINCIPAL_INVESTIGATOR
Medical University Vienna
Andreas Repa, MD
Role: PRINCIPAL_INVESTIGATOR
Medical University Vienna
References
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Repa A, Lochmann R, Unterasinger L, Weber M, Berger A, Haiden N. Aggressive nutrition in extremely low birth weight infants: impact on parenteral nutrition associated cholestasis and growth. PeerJ. 2016 Sep 20;4:e2483. doi: 10.7717/peerj.2483. eCollection 2016.
Study Documents
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Related Links
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Open source article
Other Identifiers
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MUVNeo-1
Identifier Type: -
Identifier Source: org_study_id
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