Perfusion CT as a Predictor of Treatment Response in Patients With Hepatic Malignancies

NCT ID: NCT01163526

Last Updated: 2017-01-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

13 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-09-30

Study Completion Date

2016-07-31

Brief Summary

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A research study of liver perfusion (how blood flows to the liver over time). We hope to learn whether perfusion characteristics of liver masses may be predictive of response to treatment and whether liver perfusion characteristics can be used to follow response to treatment.

Detailed Description

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Conditions

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Neuroendocrine Tumors Brain (Nervous System) Cancers Colon/Rectal Cancer Colon Cancer Hepatobiliary Cancers Hepatocellular Carcinoma (Hepatoma) Liver

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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neuroendocrine metastases

15 patients with neuroendocrine metastases

CT perfusion

Intervention Type PROCEDURE

colon cancer metastases

15 patients with colon cancer metastases

CT perfusion

Intervention Type PROCEDURE

HCC treated with cyberknife radiation and chemotherapy

15 patients with HCC treated with cyberknife radiation and chemotherapy

CT perfusion

Intervention Type PROCEDURE

HCC treated with Sirsphere embolization and chemotherapy

15 patients with HCC treated with Sirsphere embolization and chemotherapy

CT perfusion

Intervention Type PROCEDURE

Interventions

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CT perfusion

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

3.1.2 Patients who have undergone prior chemotherapy more than one year prior to the study are eligible for enrollment.

3.1.4 Patients must be 18 years or older. Patients must not be pregnant and, if of child-bearing age, must take precautions not to become pregnant.

3.1.5 No life expectancy restrictions.

3.1.6 ECOG and Karnofsky Performance Status will not be employed.

3.1.7 Patients with renal failure are ineligible for this study (Glomerular filtration rate (GFR) must be \> 60)

Exclusion Criteria

3.2.2 No restrictions regarding use of other investigational agents.

3.2.3 Patients with severe contrast allergy are ineligible.

3.2.4 Patients who are pregnant or are trying to become pregnant are excluded from this study.

3.2.5 Patients who are cancer survivors or Human Immunodeficiency Virus (HIV)-positive will not be excluded.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Siemens Corporation, Corporate Technology

INDUSTRY

Sponsor Role collaborator

GE Healthcare

INDUSTRY

Sponsor Role collaborator

Stanford University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Aya Kamaya

Role: PRINCIPAL_INVESTIGATOR

Stanford University

Locations

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Stanford University School of Medicine

Stanford, California, United States

Site Status

Countries

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United States

Other Identifiers

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SU-07092010-6491

Identifier Type: OTHER

Identifier Source: secondary_id

HEP0031

Identifier Type: -

Identifier Source: org_study_id

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