Trial Outcomes & Findings for Maintaining Autonomy as we Age. Strategy Training for Age-related Executive Dysfunction. (NCT NCT01163279)

NCT ID: NCT01163279

Last Updated: 2017-12-18

Results Overview

COPM is a standardized semi-structure interview in which participants identify goals related to everyday life activities. Goals considered improved to criterion are those that had 2 or more points increase on COPM ratings.

• Recruitment status: COMPLETED
• Study phase: NA
• Target enrollment: 19 participants
• Primary outcome timeframe: Immediately post intervention (2 months) and 3 months later
• Results posted on: 2017-12-18

Participant Flow

Participants were recruited from a research subject pool and a community psycho-education program at Baycrest.

A total of 96 participants were assessed for study eligibility. 60 participants were excluded after a phone screening interview and 17 were excluded after a more detailed baseline assessment which included cognitive paper and pencil tasks. The remaining 19 participants were randomized to either the experimental arm or the control arm.

Participant milestones

Measure	Cogntive Training Real world strategy approach: The key features of the protocol are: i. Participants are actively engaged in selecting their treatment goals. The research clinician will work with the participants to identify five specific, measurable real-world goals using a standardized semi-structured interview, the Canadian Occupational Performance Measure. Three of these will be training goals, two will not be trained but evaluated post-intervention for evidence of generalization and transfer to non-trained tasks; ii. A global problem solving approach is used (Goal- Plan- Do- Check). Participants are guided by the trainer to apply this strategy to their goals.	Psychosocial Education The active comparator was an information-based format and is designed to engage participants without providing any specific training techniques or strategies. During weekly sessions, participants received factual information on brain structure and function, age-related cognitive changes, and general brain health issues and spent time doing non-specific cognitive exercises including crossword and Sudoku puzzles. Homework consisted of reading assignments related to the session topics.
Overall Study STARTED	10	9
Overall Study COMPLETED	8	9
Overall Study NOT COMPLETED	2	0

Reasons for withdrawal

Measure	Cogntive Training Real world strategy approach: The key features of the protocol are: i. Participants are actively engaged in selecting their treatment goals. The research clinician will work with the participants to identify five specific, measurable real-world goals using a standardized semi-structured interview, the Canadian Occupational Performance Measure. Three of these will be training goals, two will not be trained but evaluated post-intervention for evidence of generalization and transfer to non-trained tasks; ii. A global problem solving approach is used (Goal- Plan- Do- Check). Participants are guided by the trainer to apply this strategy to their goals.	Psychosocial Education The active comparator was an information-based format and is designed to engage participants without providing any specific training techniques or strategies. During weekly sessions, participants received factual information on brain structure and function, age-related cognitive changes, and general brain health issues and spent time doing non-specific cognitive exercises including crossword and Sudoku puzzles. Homework consisted of reading assignments related to the session topics.
Overall Study Withdrawal by Subject	2	0

Baseline Characteristics

Maintaining Autonomy as we Age. Strategy Training for Age-related Executive Dysfunction.

Baseline characteristics by cohort

Measure	Cognitive Training n=10 Participants Real world strategy approach: The key features of the protocol are: i. Participants are actively engaged in selecting their treatment goals. The research clinician will work with the participants to identify five specific, measurable real-world goals using a standardized semi-structured interview, the Canadian Occupational Performance Measure. Three of these will be training goals, two will not be trained but evaluated post-intervention for evidence of generalization and transfer to non-trained tasks; ii. A global problem solving approach is used (Goal- Plan- Do- Check). Participants are guided by the trainer to apply this strategy to their goals.	Psychosocial Education n=9 Participants The active comparator uses an information-based format and is designed to engage participants without providing any specific training techniques or strategies. During weekly sessions, participants will receive factual information on brain structure and function, age-related cognitive changes, and general brain health issues and will spend time doing non-specific cognitive exercises including crossword and Sudoku puzzles. Homework will consist of reading assignments related to the session topics.	Total n=19 Participants Total of all reporting groups
Age, Categorical <=18 years	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants
Age, Categorical Between 18 and 65 years	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants
Age, Categorical >=65 years	10 Participants n=5 Participants	9 Participants n=7 Participants	19 Participants n=5 Participants
Age, Continuous	74.10 years STANDARD_DEVIATION 8.77 • n=5 Participants	73.67 years STANDARD_DEVIATION 5.43 • n=7 Participants	73.94 years STANDARD_DEVIATION 7.18 • n=5 Participants
Sex: Female, Male Female	9 Participants n=5 Participants	7 Participants n=7 Participants	16 Participants n=5 Participants
Sex: Female, Male Male	1 Participants n=5 Participants	2 Participants n=7 Participants	3 Participants n=5 Participants
Region of Enrollment Canada	10 participants n=5 Participants	9 participants n=7 Participants	19 participants n=5 Participants

PRIMARY outcome

Timeframe: Immediately post intervention (2 months) and 3 months later

Population: Intention to treat analysis was done therefore, the analysis population includes all participants who were randomized (n=19).

COPM is a standardized semi-structure interview in which participants identify goals related to everyday life activities. Goals considered improved to criterion are those that had 2 or more points increase on COPM ratings.

Outcome measures

Measure	Cognitive Training n=52 Total number of goals Real world strategy approach: The key features of the protocol are: i. Participants are actively engaged in selecting their treatment goals. The research clinician will work with the participants to identify five specific, measurable real-world goals using a standardized semi-structured interview, the Canadian Occupational Performance Measure. Three of these will be training goals, two will not be trained but evaluated post-intervention for evidence of generalization and transfer to non-trained tasks; ii. A global problem solving approach is used (Goal- Plan- Do- Check). Participants are guided by the trainer to apply this strategy to their goals.	Psychosocial Education n=46 Total number of goals The active comparator uses an information-based format and is designed to engage participants without providing any specific training techniques or strategies. During weekly sessions, participants will receive factual information on brain structure and function, age-related cognitive changes, and general brain health issues and will spend time doing non-specific cognitive exercises including crossword and Sudoku puzzles. Homework will consist of reading assignments related to the session topics.
Total Number of Goals Improved to Criterion on the Canadian Occupational Performance Measure (COPM) post intervention performance	50 percentage of untrained goals improved	19.6 percentage of untrained goals improved
Total Number of Goals Improved to Criterion on the Canadian Occupational Performance Measure (COPM) post intervention satisfaction	50 percentage of untrained goals improved	32.6 percentage of untrained goals improved
Total Number of Goals Improved to Criterion on the Canadian Occupational Performance Measure (COPM) 3-month follow up performance	36.4 percentage of untrained goals improved	26.1 percentage of untrained goals improved
Total Number of Goals Improved to Criterion on the Canadian Occupational Performance Measure (COPM) 3-month follow up satisfaction	45.5 percentage of untrained goals improved	28.3 percentage of untrained goals improved

SECONDARY outcome

Timeframe: Baseline, Immediately post intervention (2 months) and 3 months later

Population: Intention to treat analysis was done therefore, the analysis population includes all participants who were randomized (n=19).

GSE is a self efficacy scale with a minimum score of 10 and a maximum score of 40. Higher scores indicate higher self efficacy

Outcome measures

Measure	Cognitive Training n=10 Participants Real world strategy approach: The key features of the protocol are: i. Participants are actively engaged in selecting their treatment goals. The research clinician will work with the participants to identify five specific, measurable real-world goals using a standardized semi-structured interview, the Canadian Occupational Performance Measure. Three of these will be training goals, two will not be trained but evaluated post-intervention for evidence of generalization and transfer to non-trained tasks; ii. A global problem solving approach is used (Goal- Plan- Do- Check). Participants are guided by the trainer to apply this strategy to their goals.	Psychosocial Education n=9 Participants The active comparator uses an information-based format and is designed to engage participants without providing any specific training techniques or strategies. During weekly sessions, participants will receive factual information on brain structure and function, age-related cognitive changes, and general brain health issues and will spend time doing non-specific cognitive exercises including crossword and Sudoku puzzles. Homework will consist of reading assignments related to the session topics.
General Self Efficacy Scale (GSE) Baseline	29.10 Scores on scale Standard Deviation 3.41	32.56 Scores on scale Standard Deviation 3.40
General Self Efficacy Scale (GSE) Immediately post intervention (2 months)	30.90 Scores on scale Standard Deviation 3.98	33.56 Scores on scale Standard Deviation 4.28
General Self Efficacy Scale (GSE) 3 months post intervention	30.50 Scores on scale Standard Deviation 4.12	33.56 Scores on scale Standard Deviation 3.43

SECONDARY outcome

Timeframe: Baseline, Immediately post intervention (2 months) and 3 months later

Population: Intention to treat analysis was done therefore, the analysis population includes all participants who were randomized (n=19).

Stanford Patient Education Research Center has different measures of health related behaviors. General Health is one of the subscales. scores range 1-5 and higher score indicate better general health

Outcome measures

Measure	Cognitive Training n=10 Participants Real world strategy approach: The key features of the protocol are: i. Participants are actively engaged in selecting their treatment goals. The research clinician will work with the participants to identify five specific, measurable real-world goals using a standardized semi-structured interview, the Canadian Occupational Performance Measure. Three of these will be training goals, two will not be trained but evaluated post-intervention for evidence of generalization and transfer to non-trained tasks; ii. A global problem solving approach is used (Goal- Plan- Do- Check). Participants are guided by the trainer to apply this strategy to their goals.	Psychosocial Education n=9 Participants The active comparator uses an information-based format and is designed to engage participants without providing any specific training techniques or strategies. During weekly sessions, participants will receive factual information on brain structure and function, age-related cognitive changes, and general brain health issues and will spend time doing non-specific cognitive exercises including crossword and Sudoku puzzles. Homework will consist of reading assignments related to the session topics.
Stanford Patient Education Research Center- General Health Subscale Baseline	2.20 units on a scale Standard Deviation 0.63	1.89 units on a scale Standard Deviation 0.78
Stanford Patient Education Research Center- General Health Subscale Immediately post intervention (2 months)	2.20 units on a scale Standard Deviation 0.42	1.78 units on a scale Standard Deviation 0.83
Stanford Patient Education Research Center- General Health Subscale 3 months post intervention	2.20 units on a scale Standard Deviation 0.92	2.00 units on a scale Standard Deviation 0.87

SECONDARY outcome

Timeframe: Baseline, Immediately post intervention (2 months) and 3 months later

Population: Intention to treat analysis was done therefore, the analysis population includes all participants who were randomized (n=19).

Stanford Patient Education Research Center has different measures of health related behaviors. Health distress is one of the subscales. Scores range 0-20 and higher score indicates more distress.

Outcome measures

Measure	Cognitive Training n=10 Participants Real world strategy approach: The key features of the protocol are: i. Participants are actively engaged in selecting their treatment goals. The research clinician will work with the participants to identify five specific, measurable real-world goals using a standardized semi-structured interview, the Canadian Occupational Performance Measure. Three of these will be training goals, two will not be trained but evaluated post-intervention for evidence of generalization and transfer to non-trained tasks; ii. A global problem solving approach is used (Goal- Plan- Do- Check). Participants are guided by the trainer to apply this strategy to their goals.	Psychosocial Education n=9 Participants The active comparator uses an information-based format and is designed to engage participants without providing any specific training techniques or strategies. During weekly sessions, participants will receive factual information on brain structure and function, age-related cognitive changes, and general brain health issues and will spend time doing non-specific cognitive exercises including crossword and Sudoku puzzles. Homework will consist of reading assignments related to the session topics.
Stanford Patient Education Research Center- Health Distress Subscale Baseline	2.70 units on a scale Standard Deviation 2.21	4.22 units on a scale Standard Deviation 2.77
Stanford Patient Education Research Center- Health Distress Subscale Immediately post intervention (2 months)	3.80 units on a scale Standard Deviation 3.46	3.67 units on a scale Standard Deviation 4.21
Stanford Patient Education Research Center- Health Distress Subscale 3 months post intervention	3.70 units on a scale Standard Deviation 3.37	4.11 units on a scale Standard Deviation 2.03

SECONDARY outcome

Timeframe: Baseline, Immediately post intervention (2 months) and 3 months later

Population: Intention to treat analysis was done therefore, the analysis population includes all participants who were randomized (n=19).

Stanford Patient Education Research Center has different measures of health related behaviors. Physical activity is one of the subscales. Scores indicate number of hours of physical activity per week

Outcome measures

Measure	Cognitive Training n=10 Participants Real world strategy approach: The key features of the protocol are: i. Participants are actively engaged in selecting their treatment goals. The research clinician will work with the participants to identify five specific, measurable real-world goals using a standardized semi-structured interview, the Canadian Occupational Performance Measure. Three of these will be training goals, two will not be trained but evaluated post-intervention for evidence of generalization and transfer to non-trained tasks; ii. A global problem solving approach is used (Goal- Plan- Do- Check). Participants are guided by the trainer to apply this strategy to their goals.	Psychosocial Education n=9 Participants The active comparator uses an information-based format and is designed to engage participants without providing any specific training techniques or strategies. During weekly sessions, participants will receive factual information on brain structure and function, age-related cognitive changes, and general brain health issues and will spend time doing non-specific cognitive exercises including crossword and Sudoku puzzles. Homework will consist of reading assignments related to the session topics.
Stanford Patient Education Research Center- Physical Activity Subscale Baseline	4.08 hours of physical activity/week Standard Deviation 2.22	5.31 hours of physical activity/week Standard Deviation 1.47
Stanford Patient Education Research Center- Physical Activity Subscale Immediately post intervention (2 months)	4.45 hours of physical activity/week Standard Deviation 2.53	3.64 hours of physical activity/week Standard Deviation 1.35
Stanford Patient Education Research Center- Physical Activity Subscale 3 months post intervention	4.15 hours of physical activity/week Standard Deviation 1.83	3.19 hours of physical activity/week Standard Deviation 1.56

SECONDARY outcome

Timeframe: Baseline, Immediately post intervention (2 months) and 3 months later

Population: Intention to treat analysis was done therefore, the analysis population includes all participants who were randomized (n=19).

Stanford Patient Education Research Center has different measures of health related behaviors. communication with physicians is one of the subscales. Scores range 1-15 and higher score indicates more preparation for visits and greater ability to ask questions

Outcome measures

Measure	Cognitive Training n=10 Participants Real world strategy approach: The key features of the protocol are: i. Participants are actively engaged in selecting their treatment goals. The research clinician will work with the participants to identify five specific, measurable real-world goals using a standardized semi-structured interview, the Canadian Occupational Performance Measure. Three of these will be training goals, two will not be trained but evaluated post-intervention for evidence of generalization and transfer to non-trained tasks; ii. A global problem solving approach is used (Goal- Plan- Do- Check). Participants are guided by the trainer to apply this strategy to their goals.	Psychosocial Education n=9 Participants The active comparator uses an information-based format and is designed to engage participants without providing any specific training techniques or strategies. During weekly sessions, participants will receive factual information on brain structure and function, age-related cognitive changes, and general brain health issues and will spend time doing non-specific cognitive exercises including crossword and Sudoku puzzles. Homework will consist of reading assignments related to the session topics.
Stanford Patient Education Research Center- Communication With Physicians Subscale Baseline	8.40 units on a scale Standard Deviation 3.84	11.00 units on a scale Standard Deviation 3.04
Stanford Patient Education Research Center- Communication With Physicians Subscale Immediately post intervention (2 months)	9.50 units on a scale Standard Deviation 4.17	9.11 units on a scale Standard Deviation 3.33
Stanford Patient Education Research Center- Communication With Physicians Subscale 3 months post intervention	10.00 units on a scale Standard Deviation 3.80	8.89 units on a scale Standard Deviation 4.17

SECONDARY outcome

Timeframe: Baseline, Immediately post intervention (2 months) and 3 months later

Population: Intention to treat analysis was done therefore, the analysis population includes all participants who were randomized (n=19).

Stanford Patient Education Research Center has different measures of health related behaviors. Visits to physician and emergency department in the past six months subscale is one of the subscales.

Outcome measures

Measure	Cognitive Training n=10 Participants Real world strategy approach: The key features of the protocol are: i. Participants are actively engaged in selecting their treatment goals. The research clinician will work with the participants to identify five specific, measurable real-world goals using a standardized semi-structured interview, the Canadian Occupational Performance Measure. Three of these will be training goals, two will not be trained but evaluated post-intervention for evidence of generalization and transfer to non-trained tasks; ii. A global problem solving approach is used (Goal- Plan- Do- Check). Participants are guided by the trainer to apply this strategy to their goals.	Psychosocial Education n=9 Participants The active comparator uses an information-based format and is designed to engage participants without providing any specific training techniques or strategies. During weekly sessions, participants will receive factual information on brain structure and function, age-related cognitive changes, and general brain health issues and will spend time doing non-specific cognitive exercises including crossword and Sudoku puzzles. Homework will consist of reading assignments related to the session topics.
Stanford Patient Education Research Center- Visits to Physician and Emergency Department in the Past Six Months Subscale Baseline	2.30 number of visits Standard Deviation 0.95	2.78 number of visits Standard Deviation 3.07
Stanford Patient Education Research Center- Visits to Physician and Emergency Department in the Past Six Months Subscale Immediately post intervention (2 months)	1.50 number of visits Standard Deviation 0.97	3.33 number of visits Standard Deviation 4.00
Stanford Patient Education Research Center- Visits to Physician and Emergency Department in the Past Six Months Subscale 3 months post intervention	2.00 number of visits Standard Deviation 1.24	2.33 number of visits Standard Deviation 2.74

SECONDARY outcome

Timeframe: Baseline, Immediately post intervention (2 months) and 3 months later

Population: Intention to treat analysis was done therefore, the analysis population includes all participants who were randomized (n=19).

This is a measure of executive function. The score reflects the average of the participant's first-move times, i.e. the time a participant took to make the first move

Outcome measures

Measure	Cognitive Training n=10 Participants Real world strategy approach: The key features of the protocol are: i. Participants are actively engaged in selecting their treatment goals. The research clinician will work with the participants to identify five specific, measurable real-world goals using a standardized semi-structured interview, the Canadian Occupational Performance Measure. Three of these will be training goals, two will not be trained but evaluated post-intervention for evidence of generalization and transfer to non-trained tasks; ii. A global problem solving approach is used (Goal- Plan- Do- Check). Participants are guided by the trainer to apply this strategy to their goals.	Psychosocial Education n=9 Participants The active comparator uses an information-based format and is designed to engage participants without providing any specific training techniques or strategies. During weekly sessions, participants will receive factual information on brain structure and function, age-related cognitive changes, and general brain health issues and will spend time doing non-specific cognitive exercises including crossword and Sudoku puzzles. Homework will consist of reading assignments related to the session topics.
Delis Kaplan Executive Function System (DKEFS) Tower Test- Mean First-Move Time Baseline	5.48 Time in seconds Standard Deviation 3.72	6.13 Time in seconds Standard Deviation 5.83
Delis Kaplan Executive Function System (DKEFS) Tower Test- Mean First-Move Time Immediately post intervention (2 months)	3.00 Time in seconds Standard Deviation 1.72	3.69 Time in seconds Standard Deviation 2.89
Delis Kaplan Executive Function System (DKEFS) Tower Test- Mean First-Move Time 3 months post intervention	2.47 Time in seconds Standard Deviation 1.78	1.72 Time in seconds Standard Deviation 0.71

SECONDARY outcome

Timeframe: Baseline, Immediately post intervention (2 months) and 3 months later

Population: Intention to treat analysis was done therefore, the analysis population includes all participants who were randomized (n=19).

This is a measure of executive function. Total achievement scores indicate the highest score participants scored on the test. The lowest score possible is 0 and the highest score possible is 30. Higher scores indicate better performance.

Outcome measures

Measure	Cognitive Training n=10 Participants Real world strategy approach: The key features of the protocol are: i. Participants are actively engaged in selecting their treatment goals. The research clinician will work with the participants to identify five specific, measurable real-world goals using a standardized semi-structured interview, the Canadian Occupational Performance Measure. Three of these will be training goals, two will not be trained but evaluated post-intervention for evidence of generalization and transfer to non-trained tasks; ii. A global problem solving approach is used (Goal- Plan- Do- Check). Participants are guided by the trainer to apply this strategy to their goals.	Psychosocial Education n=9 Participants The active comparator uses an information-based format and is designed to engage participants without providing any specific training techniques or strategies. During weekly sessions, participants will receive factual information on brain structure and function, age-related cognitive changes, and general brain health issues and will spend time doing non-specific cognitive exercises including crossword and Sudoku puzzles. Homework will consist of reading assignments related to the session topics.
DKEFS Tower Test- Achievement Score Baseline	17.10 units on a scale Standard Deviation 3.57	15.78 units on a scale Standard Deviation 4.09
DKEFS Tower Test- Achievement Score Immediately post intervention (2 months)	18.30 units on a scale Standard Deviation 3.59	19.44 units on a scale Standard Deviation 4.07
DKEFS Tower Test- Achievement Score 3 months post intervention	20.90 units on a scale Standard Deviation 4.31	18.89 units on a scale Standard Deviation 3.30

SECONDARY outcome

Timeframe: Baseline, Immediately post intervention (2 months) and 3 months later

Population: Intention to treat analysis was done therefore, the analysis population includes all participants who were randomized (n=19).

This is a measure of executive function where participants are given a letter and asked to generate as many words as they can think of within 60 seconds

Outcome measures

Measure	Cognitive Training n=10 Participants Real world strategy approach: The key features of the protocol are: i. Participants are actively engaged in selecting their treatment goals. The research clinician will work with the participants to identify five specific, measurable real-world goals using a standardized semi-structured interview, the Canadian Occupational Performance Measure. Three of these will be training goals, two will not be trained but evaluated post-intervention for evidence of generalization and transfer to non-trained tasks; ii. A global problem solving approach is used (Goal- Plan- Do- Check). Participants are guided by the trainer to apply this strategy to their goals.	Psychosocial Education n=9 Participants The active comparator uses an information-based format and is designed to engage participants without providing any specific training techniques or strategies. During weekly sessions, participants will receive factual information on brain structure and function, age-related cognitive changes, and general brain health issues and will spend time doing non-specific cognitive exercises including crossword and Sudoku puzzles. Homework will consist of reading assignments related to the session topics.
DKEFS Word Fluency Baseline	55.30 Number of words generated Standard Deviation 15.25	48.56 Number of words generated Standard Deviation 11.74
DKEFS Word Fluency Immediately post intervention (2 months)	56.40 Number of words generated Standard Deviation 18.38	50.33 Number of words generated Standard Deviation 9.12
DKEFS Word Fluency 3 months post intervention	57.40 Number of words generated Standard Deviation 16.34	50.11 Number of words generated Standard Deviation 13.05

SECONDARY outcome

Timeframe: Baseline, Immediately post intervention (2 months) and 3 months later

Population: Intention to treat analysis was done therefore, the analysis population includes all participants who were randomized (n=19).

DKEFS trail making condition 4 is a measure of executive function that requires the participant to switch back and forth between connecting numbers and letters in a sequence

Outcome measures

Measure	Cognitive Training n=10 Participants Real world strategy approach: The key features of the protocol are: i. Participants are actively engaged in selecting their treatment goals. The research clinician will work with the participants to identify five specific, measurable real-world goals using a standardized semi-structured interview, the Canadian Occupational Performance Measure. Three of these will be training goals, two will not be trained but evaluated post-intervention for evidence of generalization and transfer to non-trained tasks; ii. A global problem solving approach is used (Goal- Plan- Do- Check). Participants are guided by the trainer to apply this strategy to their goals.	Psychosocial Education n=9 Participants The active comparator uses an information-based format and is designed to engage participants without providing any specific training techniques or strategies. During weekly sessions, participants will receive factual information on brain structure and function, age-related cognitive changes, and general brain health issues and will spend time doing non-specific cognitive exercises including crossword and Sudoku puzzles. Homework will consist of reading assignments related to the session topics.
DKEFS Trail Making- Condition 4: Number-letter Switching Baseline	104.50 Time in seconds Standard Deviation 43.87	91.11 Time in seconds Standard Deviation 19.19
DKEFS Trail Making- Condition 4: Number-letter Switching Immediately post intervention (2 months)	88.40 Time in seconds Standard Deviation 28.55	80.56 Time in seconds Standard Deviation 25.37
DKEFS Trail Making- Condition 4: Number-letter Switching 3 months post intervention	94.10 Time in seconds Standard Deviation 32.70	84.44 Time in seconds Standard Deviation 31.33

Adverse Events

Cognitive Training

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Psychosocial Education

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Dr. Deirdre Dawson

Baycrest Health Sciences

Phone: 416-785-2500

Email: ddawson@research.baycrest.org

Results disclosure agreements

• Principal investigator is a sponsor employee
• Publication restrictions are in place