Chlorhexidine Mouthwash and Bacterial Contamination During Endoscopy
NCT ID: NCT01154530
Last Updated: 2011-08-17
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
Recruitment Status
COMPLETED
Clinical Phase
NA
Total Enrollment
102 participants
Study Classification
INTERVENTIONAL
Study Start Date
2011-01-31
Study Completion Date
2011-08-31
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Background:
Natural Orifice Transluminal Endoscopic Surgery (NOTES) is a surgical technique that has been rapidly evolving over the last five years. The technique probably has a great potential in surgical gastroenterology, urology and gynaecology.
The technique is based on the idea of minimally invasive surgery. The human organism is affected by a stress response when exposed to surgery. This stress response can be minimized by reducing the size of the openings whereby the surgeon gains access to the organs. This affects how quickly a patient recovers after surgery and can be discharged and resumes daily life and work. The same principal have been responsible for the surgical evolution in the last 15-20 years where many procedures have gone from traditional open operations with large incisions in the abdominal wall to laparoscopic surgery with cameras through small holes in the abdominal wall.
The latest addition to minimal invasive surgery is NOTES. Here the surgeon gains access to the abdominal organs with flexible endoscopes through the body's natural openings i.e. the mouth and stomach. With this technique the surgeon avoids cutting through skin and muscle of the abdominal wall, thus minimizing the surgical stress response. This minimizes postoperative pain, the incidence of incisional hernias, eliminates wound infection, and properly prevents scar tissue formation inside the abdominal cavity which way lead to ileus. The end result is a quicker discharge and a better cosmetic result.
It has been shown in numerous animal studies that NOTES is feasible and in recent years a rapidly increasing number of published patient series.
However, there is a risk of infection associated with accessing the abdominal cavity through a natural body opening, which initially is unclean and can not be disinfected in the same way as the skin of the abdominal wall.
Numerous microbiological pig studies have shown that there is transfer of bacteria from the body opening (i.e. mouth) to the abdominal cavity when performing NOTES, but this contamination have no correlation to infection after surgery, neither in terms of healing or survival.
It is unclear from the literature whether patients should be offered proton pump inhibitor (PPI) therapy to reduce the acidity of the stomach before NOTES interventions. The rationale has been that such a treatment can make the gastric juices less acidic and thereby reduce the incidence of chemical peritonitis, which can occur when acidic juices flows from the stomach and into the abdominal cavity. It is known however that the acidic environment of the stomach provides a natural barrier for bacteria. Making the gastric juices less acidic could potentially increase the risk of bacterial peritonitis.
It is known that the bacterial content of the stomach is low due the acidic environment but bacteria passed down from the mouth and throat with the endoscope could potentially result in bacterial peritonitis.
That bacteria from the throat can lead to infections due to instrumentation is known from intensive care units. Ventilated patients may risk getting pneumonia with bacteria from the throat. Several studies have shown that using mouthwash with a chlorhexidine solution can reduce the risk of ventilator associated pneumonia.
Hypothesis:
Mouthwash with 2 cl 0,2% chlorhexidine solution before a gastroscopy reduces the bacterial content in cultures taken from the stomach and the endoscope after a gastroscopy.
Simultaneous PPI treatment gives higher bacterial counts in the cultures.
Natural Orifice Transluminal Endoscopic Surgery (NOTES) is a surgical technique that has been rapidly evolving over the last five years. The technique probably has a great potential in surgical gastroenterology, urology and gynaecology.
The technique is based on the idea of minimally invasive surgery. The human organism is affected by a stress response when exposed to surgery. This stress response can be minimized by reducing the size of the openings whereby the surgeon gains access to the organs. This affects how quickly a patient recovers after surgery and can be discharged and resumes daily life and work. The same principal have been responsible for the surgical evolution in the last 15-20 years where many procedures have gone from traditional open operations with large incisions in the abdominal wall to laparoscopic surgery with cameras through small holes in the abdominal wall.
The latest addition to minimal invasive surgery is NOTES. Here the surgeon gains access to the abdominal organs with flexible endoscopes through the body's natural openings i.e. the mouth and stomach. With this technique the surgeon avoids cutting through skin and muscle of the abdominal wall, thus minimizing the surgical stress response. This minimizes postoperative pain, the incidence of incisional hernias, eliminates wound infection, and properly prevents scar tissue formation inside the abdominal cavity which way lead to ileus. The end result is a quicker discharge and a better cosmetic result.
It has been shown in numerous animal studies that NOTES is feasible and in recent years a rapidly increasing number of published patient series.
However, there is a risk of infection associated with accessing the abdominal cavity through a natural body opening, which initially is unclean and can not be disinfected in the same way as the skin of the abdominal wall.
Numerous microbiological pig studies have shown that there is transfer of bacteria from the body opening (i.e. mouth) to the abdominal cavity when performing NOTES, but this contamination have no correlation to infection after surgery, neither in terms of healing or survival.
It is unclear from the literature whether patients should be offered proton pump inhibitor (PPI) therapy to reduce the acidity of the stomach before NOTES interventions. The rationale has been that such a treatment can make the gastric juices less acidic and thereby reduce the incidence of chemical peritonitis, which can occur when acidic juices flows from the stomach and into the abdominal cavity. It is known however that the acidic environment of the stomach provides a natural barrier for bacteria. Making the gastric juices less acidic could potentially increase the risk of bacterial peritonitis.
It is known that the bacterial content of the stomach is low due the acidic environment but bacteria passed down from the mouth and throat with the endoscope could potentially result in bacterial peritonitis.
That bacteria from the throat can lead to infections due to instrumentation is known from intensive care units. Ventilated patients may risk getting pneumonia with bacteria from the throat. Several studies have shown that using mouthwash with a chlorhexidine solution can reduce the risk of ventilator associated pneumonia.
Hypothesis:
Mouthwash with 2 cl 0,2% chlorhexidine solution before a gastroscopy reduces the bacterial content in cultures taken from the stomach and the endoscope after a gastroscopy.
Simultaneous PPI treatment gives higher bacterial counts in the cultures.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
The Effect of Two Different Endoscopic Entry Techniques on Postoperative Gastrointestinal Function
NCT02543853
Gastrointestinal Disorder Postoperative
UNKNOWN
NA
Postoperative Gastroesophageal Reflux Symptoms After Laparoscopic Sleeve Gastrectomy Based on the Presence of Preoperative Symptoms
NCT06835933
Obesity and Obesity-related Medical Conditions
Laparoscopic Sleeve Gastrectomy
Gastro-oesophageal Reflux
ACTIVE_NOT_RECRUITING
Testing for Bacterial Contamination During Gastric Surgeries
NCT00417651
Gastric Surgery
COMPLETED
Preoperative Viscous Lidocaine for Upper Gastrointestinal Endoscopy
NCT04725695
Anesthetics, Local
Esophagogastroduodenoscopy
TERMINATED
PHASE4
Pathophysiology of Perioperative Fluid Management in Emergency Laparotomy
NCT03997721
Intestinal Obstruction
Intestinal Perforation
Anastomotic Leak
+2 more
COMPLETED
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Background:
Natural Orifice Transluminal Endoscopic Surgery (NOTES) is a surgical technique that has been rapidly evolving over the last five years. The technique probably has a great potential in surgical gastroenterology, urology and gynaecology.
The technique is based on the idea of minimally invasive surgery. The human organism is affected by a stress response when exposed to surgery. This stress response can be minimized by reducing the size of the openings whereby the surgeon gains access to the organs. This affects how quickly a patient recovers after surgery and can be discharged and resumes daily life and work. The same principal have been responsible for the surgical evolution in the last 15-20 years where many procedures have gone from traditional open operations with large incisions in the abdominal wall to laparoscopic surgery with cameras through small holes in the abdominal wall.
The latest addition to minimal invasive surgery is NOTES. Here the surgeon gains access to the abdominal organs with flexible endoscopes through the body's natural openings i.e. the mouth and stomach. With this technique the surgeon avoids cutting through skin and muscle of the abdominal wall, thus minimizing the surgical stress response. This minimizes postoperative pain, the incidence of incisional hernias, eliminates wound infection, and properly prevents scar tissue formation inside the abdominal cavity which way lead to ileus. The end result is a quicker discharge and a better cosmetic result.
It has been shown in numerous animal studies that NOTES is feasible and in recent years a rapidly increasing number of published patient series.
However, there is a risk of infection associated with accessing the abdominal cavity through a natural body opening, which initially is unclean and can not be disinfected in the same way as the skin of the abdominal wall.
Numerous microbiological pig studies have shown that there is transfer of bacteria from the body opening (i.e. mouth) to the abdominal cavity when performing NOTES, but this contamination have no correlation to infection after surgery, neither in terms of healing or survival.
It is unclear from the literature whether patients should be offered proton pump inhibitor (PPI) therapy to reduce the acidity of the stomach before NOTES interventions. The rationale has been that such a treatment can make the gastric juices less acidic and thereby reduce the incidence of chemical peritonitis, which can occur when acidic juices flows from the stomach and into the abdominal cavity. It is known however that the acidic environment of the stomach provides a natural barrier for bacteria. Making the gastric juices less acidic could potentially increase the risk of bacterial peritonitis.
It is known that the bacterial content of the stomach is low due the acidic environment but bacteria passed down from the mouth and throat with the endoscope could potentially result in bacterial peritonitis.
That bacteria from the throat can lead to infections due to instrumentation is known from intensive care units. Ventilated patients may risk getting pneumonia with bacteria from the throat. Several studies have shown that using mouthwash with a chlorhexidine solution can reduce the risk of ventilator associated pneumonia.
Hypothesis:
Mouthwash with 2 cl 0,2% chlorhexidine solution before a gastroscopy reduces the bacterial content in cultures taken from the stomach and the endoscope after a gastroscopy.
Simultaneous PPI treatment gives higher bacterial counts in the cultures.
Trial Participants:
Trial Participants will be recruited among patients referred to gastroscopy in an outpatient setting, at Herlev, Gentofte and Bispebjerg Hospital.
Participants must be over 18 years old regardless of gender. The participants are included after oral and written information about the trial and with written consent. The request for participation and written information about the trial is send to the patient by conventional mail. The oral information is given on the day of the gastroscopy. Inclusion in the trial has no consequences for the purpose of the gastroscopy, or on any further diagnostic procedures or treatments. Trial Participants may at any time withdraw from the trial without consequences.
Method:
Included participants are randomized by drawing a random envelope with a continuous registration number containing information on whether the patient is allocated to the intervention or control group.
Enclosed in the envelope is a registration form where the following is recorded: sex, age, weight, height, indication for gastroscopy, number of instrumentations during gastroscopy, the use of rinse and suction, and PPI treatment.
Participants in the intervention group perform a mouthwash with 2 cl 0,2% chlorhexidine for 30 seconds immediately before the gastroscopy.
Participants in the control group perform no mouthwash before the gastroscopy.
The gastroscopy is performed in accordance with the indication.
A total of 2 culture samples will be taken from each participant. The culture samples are sent to the department of clinical microbiology, Herlev Hospital for cultivation, bacterial count and typing.
The first culture sample is taken by instilling 50ml sterile saline through the instrumentation channel with the gastroscope located in the fundus of the stomach . Approximately 10ml is aspirated through the same channel in the antrum of the stomach.
The second culture sample is taken from the gastroscope after the procedure by rinsing the instrumentation channel with sterile saline. A sample of approximately 10 ml is collected at the distal end of the gastroscope.
Samples are marked with the respective continuous registration numbers according to the randomization.
Side effects, discomfort and risks:
There are no side effects associated with the use chlorhexidine mouthwash.
There is some discomfort associated with the gastroscopy. This is not a result of participation in the trial.
Many patients feel slight discomfort when the gastroscope passes through the throat. The passage can stimulate the vomiting reflex. For this reason a gastroscopy is always performed with the patient in a left lateral position to ensure free airways. There may be mild soreness and irritation in the throat during and in the first few days after the gastroscopy.
The only discomfort that is directly linked to participation in the trial is the taste of chlorhexidine mouthwash for half of the participants.
There are no risks associated with participation in the trial, although there are some risks associated with the gastroscopy itself. These are bleeding from the stomach wall and perforation of the stomach or duodenum. These complications are very rare.
Ethics:
Since the participants are recruited after referral to gastroscopy from a general practitioner the indication for the gastroscopy has already been assessed and outweighs the above mentioned rare risks.
The only discomfort that is directly related to the trail is a brief sensation of bad taste in the mouth for half of the participants.
The results gained from the trial greatly overshadow the mild discomfort associated with the taste of chlorhexidine mouthwash.
Economy:
The above mentioned trial is a part of a PhD project which tries to bridge the gap between animal studies and the implementation of NOTES in daily clinical practice.
Salaries are funded through grants from the University of Copenhagen, Herlev Hospital Research Council and the Capitol Region of Denmark Research Foundation for Health Research. Operating costs are founded through grants from private foundations. There is no commercial interest in or support for the project.
Natural Orifice Transluminal Endoscopic Surgery (NOTES) is a surgical technique that has been rapidly evolving over the last five years. The technique probably has a great potential in surgical gastroenterology, urology and gynaecology.
The technique is based on the idea of minimally invasive surgery. The human organism is affected by a stress response when exposed to surgery. This stress response can be minimized by reducing the size of the openings whereby the surgeon gains access to the organs. This affects how quickly a patient recovers after surgery and can be discharged and resumes daily life and work. The same principal have been responsible for the surgical evolution in the last 15-20 years where many procedures have gone from traditional open operations with large incisions in the abdominal wall to laparoscopic surgery with cameras through small holes in the abdominal wall.
The latest addition to minimal invasive surgery is NOTES. Here the surgeon gains access to the abdominal organs with flexible endoscopes through the body's natural openings i.e. the mouth and stomach. With this technique the surgeon avoids cutting through skin and muscle of the abdominal wall, thus minimizing the surgical stress response. This minimizes postoperative pain, the incidence of incisional hernias, eliminates wound infection, and properly prevents scar tissue formation inside the abdominal cavity which way lead to ileus. The end result is a quicker discharge and a better cosmetic result.
It has been shown in numerous animal studies that NOTES is feasible and in recent years a rapidly increasing number of published patient series.
However, there is a risk of infection associated with accessing the abdominal cavity through a natural body opening, which initially is unclean and can not be disinfected in the same way as the skin of the abdominal wall.
Numerous microbiological pig studies have shown that there is transfer of bacteria from the body opening (i.e. mouth) to the abdominal cavity when performing NOTES, but this contamination have no correlation to infection after surgery, neither in terms of healing or survival.
It is unclear from the literature whether patients should be offered proton pump inhibitor (PPI) therapy to reduce the acidity of the stomach before NOTES interventions. The rationale has been that such a treatment can make the gastric juices less acidic and thereby reduce the incidence of chemical peritonitis, which can occur when acidic juices flows from the stomach and into the abdominal cavity. It is known however that the acidic environment of the stomach provides a natural barrier for bacteria. Making the gastric juices less acidic could potentially increase the risk of bacterial peritonitis.
It is known that the bacterial content of the stomach is low due the acidic environment but bacteria passed down from the mouth and throat with the endoscope could potentially result in bacterial peritonitis.
That bacteria from the throat can lead to infections due to instrumentation is known from intensive care units. Ventilated patients may risk getting pneumonia with bacteria from the throat. Several studies have shown that using mouthwash with a chlorhexidine solution can reduce the risk of ventilator associated pneumonia.
Hypothesis:
Mouthwash with 2 cl 0,2% chlorhexidine solution before a gastroscopy reduces the bacterial content in cultures taken from the stomach and the endoscope after a gastroscopy.
Simultaneous PPI treatment gives higher bacterial counts in the cultures.
Trial Participants:
Trial Participants will be recruited among patients referred to gastroscopy in an outpatient setting, at Herlev, Gentofte and Bispebjerg Hospital.
Participants must be over 18 years old regardless of gender. The participants are included after oral and written information about the trial and with written consent. The request for participation and written information about the trial is send to the patient by conventional mail. The oral information is given on the day of the gastroscopy. Inclusion in the trial has no consequences for the purpose of the gastroscopy, or on any further diagnostic procedures or treatments. Trial Participants may at any time withdraw from the trial without consequences.
Method:
Included participants are randomized by drawing a random envelope with a continuous registration number containing information on whether the patient is allocated to the intervention or control group.
Enclosed in the envelope is a registration form where the following is recorded: sex, age, weight, height, indication for gastroscopy, number of instrumentations during gastroscopy, the use of rinse and suction, and PPI treatment.
Participants in the intervention group perform a mouthwash with 2 cl 0,2% chlorhexidine for 30 seconds immediately before the gastroscopy.
Participants in the control group perform no mouthwash before the gastroscopy.
The gastroscopy is performed in accordance with the indication.
A total of 2 culture samples will be taken from each participant. The culture samples are sent to the department of clinical microbiology, Herlev Hospital for cultivation, bacterial count and typing.
The first culture sample is taken by instilling 50ml sterile saline through the instrumentation channel with the gastroscope located in the fundus of the stomach . Approximately 10ml is aspirated through the same channel in the antrum of the stomach.
The second culture sample is taken from the gastroscope after the procedure by rinsing the instrumentation channel with sterile saline. A sample of approximately 10 ml is collected at the distal end of the gastroscope.
Samples are marked with the respective continuous registration numbers according to the randomization.
Side effects, discomfort and risks:
There are no side effects associated with the use chlorhexidine mouthwash.
There is some discomfort associated with the gastroscopy. This is not a result of participation in the trial.
Many patients feel slight discomfort when the gastroscope passes through the throat. The passage can stimulate the vomiting reflex. For this reason a gastroscopy is always performed with the patient in a left lateral position to ensure free airways. There may be mild soreness and irritation in the throat during and in the first few days after the gastroscopy.
The only discomfort that is directly linked to participation in the trial is the taste of chlorhexidine mouthwash for half of the participants.
There are no risks associated with participation in the trial, although there are some risks associated with the gastroscopy itself. These are bleeding from the stomach wall and perforation of the stomach or duodenum. These complications are very rare.
Ethics:
Since the participants are recruited after referral to gastroscopy from a general practitioner the indication for the gastroscopy has already been assessed and outweighs the above mentioned rare risks.
The only discomfort that is directly related to the trail is a brief sensation of bad taste in the mouth for half of the participants.
The results gained from the trial greatly overshadow the mild discomfort associated with the taste of chlorhexidine mouthwash.
Economy:
The above mentioned trial is a part of a PhD project which tries to bridge the gap between animal studies and the implementation of NOTES in daily clinical practice.
Salaries are funded through grants from the University of Copenhagen, Herlev Hospital Research Council and the Capitol Region of Denmark Research Foundation for Health Research. Operating costs are founded through grants from private foundations. There is no commercial interest in or support for the project.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Gastroscopy
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
Allocation Method
RANDOMIZED
Intervention Model
PARALLEL
Primary Study Purpose
PREVENTION
Blinding Strategy
NONE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Chlorhexidine mouthwash
Participants randomized to chlorhexidine mouthwash prior to gastroscopy
Group Type
ACTIVE_COMPARATOR
Chlorhexidine
Intervention Type
OTHER
Mouthwash with a 0,2 % chlorhexidine solution for 30 seconds
No mouthwash
Mouthwash is not performed prior to gastroscopy as is the standard today.
Group Type
NO_INTERVENTION
No interventions assigned to this group
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Chlorhexidine
Mouthwash with a 0,2 % chlorhexidine solution for 30 seconds
Intervention Type
OTHER
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Adult men and women over 18 years referred to gastroscopy in an outpatient setting.
* Danish speaking.
* Written informed consent after verbal and written information.
* Danish speaking.
* Written informed consent after verbal and written information.
Exclusion Criteria
* Feeding tube, or the use of a gastric or duodenal tube in the week prior to inclusion.
* Gastroscopy in the week prior to inclusion.
* Removable prosthetic teeth.
* Use of antiseptic mouthwash in the week prior to inclusion.
* Gastroenteroanastomosis.
* Gastrocystotomy.
* Stents in oesophagus / stomach / duodenum / pancreatic or hepatic ducts.
* Known cancer in esophagus / stomach / duodenum / pancreas.
* Percutaneous Endoscopic Gastrostomy / Percutaneous Ultrasonic Gastrostomy
* Known infection or in antibiotic treatment.
* Pregnant or breastfeeding.
* Gastroscopy in the week prior to inclusion.
* Removable prosthetic teeth.
* Use of antiseptic mouthwash in the week prior to inclusion.
* Gastroenteroanastomosis.
* Gastrocystotomy.
* Stents in oesophagus / stomach / duodenum / pancreatic or hepatic ducts.
* Known cancer in esophagus / stomach / duodenum / pancreas.
* Percutaneous Endoscopic Gastrostomy / Percutaneous Ultrasonic Gastrostomy
* Known infection or in antibiotic treatment.
* Pregnant or breastfeeding.
Minimum Eligible Age
18 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Bispebjerg Hospital
OTHER
Sponsor Role
collaborator
University Hospital, Gentofte, Copenhagen
OTHER
Sponsor Role
collaborator
Herlev Hospital
OTHER
Sponsor Role
lead
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Herlev Hospital, Department of surgical gastroenterology
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Anders Meller Donatsky, MD
Role: PRINCIPAL_INVESTIGATOR
Herlev Hospital, Department of surgical gastroenterology
Jacob Rosenberg, MD DSc Prof
Role: STUDY_DIRECTOR
Herlev Hospital, Department of surgical gastroenterology
Søren Meisner, MD
Role: STUDY_DIRECTOR
Bispebjerg Hospital, Department of surgical gastroenterology
Lars Nannestad Jørgensen, MD DSc prof
Role: STUDY_DIRECTOR
Bispebjerg Hospital, Department of surgical gastroenterology
Peter Vilmann, MD DSc Prof
Role: STUDY_DIRECTOR
Gentofte Hospital, Department of surgical gastroenterology
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Herlev Hospital, Department of surgical gastroenterology
Herlev, , Denmark
Site Status
Countries
Review the countries where the study has at least one active or historical site.
Denmark
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
NOTES01
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.
Endosleeve in Adolescents
NCT03778697
COMPLETED
PHASE1/PHASE2
Protocol for Patients Above 75 Years Undergoing Emergency Laparotomy
NCT04293653
COMPLETED
NA
Endoscopic Procedures of Children in the Normalization Process of Covid-19 Pandemic
NCT04598256
COMPLETED
Transoral Removal of Specimen During Laparoscopic Gastric Resection
NCT04111393
COMPLETED
Reduction of Starvation Time Prior to Gastroscopy
NCT01670253
TERMINATED
NA
Application of Laparoscopy in Gastrointestinal Injury
NCT01994148
UNKNOWN
NA
Applying Long-term Follow-up to Improve Patient Selection in Laparoscopic Anti-reflux Surgery
NCT03959020
COMPLETED
Endoscopy With Short Fasting
NCT01492296
COMPLETED
NA
Endtidalcarbondioxide Monitoring
NCT04177927
COMPLETED
NA
Assessing Gastric Motility and Distention in Postoperative Gastrointestinal Surgery Using Bedside Gastric Ultrasound: Predicting Risk of Aspiration Pneumonia, Ileus, Return of Bowel Function
NCT04747691
COMPLETED
Endoscopic Ultrasound-Guided Gastroenterostomy Nationwide: Prospective Registry.
NCT05128604
RECRUITING
Peptic Ulcer Perforation Study
NCT00624169
COMPLETED
NA
Transluminal Flexible Endoscopic Procedure in Foregut and Urologic Surgery
NCT00484783
COMPLETED
NA
Long Term Incidence and Effect of de Novo GERD After Laparoscopic Sleeve Gastrectomy in Chinese Population
NCT04237857
UNKNOWN
The Use of EndoFlip as a Clinical Tool for the Prediction of Postoperative GERD After Sleeve Gastrectomy
NCT05690022
UNKNOWN
NA
Endoscopic Treatment of Recurrent Upper GI Bleeding: OTSC [Over the Scope Clip] Versus Standard Therapy
NCT01836900
UNKNOWN
NA
Prospective Evaluation of the Efficacy and Safety of Endoscopic Tissue Apposition
NCT03626194
RECRUITING
Gastric Ultrasound
NCT04127331
COMPLETED
NA
Gastric Assessment Ambulatory Surgery
NCT03352401
COMPLETED
Prevention of Hypergranulation Tissue After Gastrostomy Tube Placement
NCT01501539
COMPLETED
NA
Complications of Laparoscopic Hiatal Hernia Repair Complicated by Gastroesophageal Reflux Disease Using the ERAS Protocol
NCT07138235
COMPLETED
Closure of Anastomotic Leaks in the Stomach and Esophagus by Endoscopic Suturing
NCT01139424
UNKNOWN
NA
Laparoscopic Ultrasound Guided Minimal Invasive Excision of Intra-/Retroperitoneal Tumors
NCT04911634
UNKNOWN
Ambulant Laparoscopic Nephrectomy; Are There Limiting Factors
NCT01600157
COMPLETED
NA