Effects of Angiotensin Converting Enzyme (ACE) Inhibitors Versus Candesartan in Reducing Cardiovascular Events in Primary Treatment of Hypertension

NCT ID: NCT01152567

Last Updated: 2011-09-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-06-30

Study Completion Date

2010-11-30

Brief Summary

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The planned Study will be a retrospective study on the effect of ACE's vs. candesartan on cardiovascular events and on health economic effects in a "real life" setting in Sweden.

Detailed Description

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Conditions

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Hypertension Cardiovascular Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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ACE

Patients treated for hypertension with ACEs without CVD

No interventions assigned to this group

Candesartan

Patients treated for hypertension with candesartan without CVD

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* all patients found in electronic patient journals at the participating centres, who were prescribed either ACEis (ATC-C09A-B) or ARBs (C09C-D) for hypertension from 1 January 1999 - 31 December 2007. The first date of such a prescription starts the observation time and is called the index prescription.

Exclusion Criteria

* No history of cardiovascular disease.
* Ongoing malignancy
Minimum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AstraZeneca

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Niklas Lindarck

Role: STUDY_DIRECTOR

AstraZeneca Nordic

Locations

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Avesta, , Sweden

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Älvdalen, , Sweden

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Ängelholm, , Sweden

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Åkersberga, , Sweden

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Bengtsfors, , Sweden

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Borlänge, , Sweden

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Falun, , Sweden

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Farsta, , Sweden

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Fritsla, , Sweden

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Gagnef, , Sweden

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Gävle, , Sweden

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Gothenburg, , Sweden

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Grängesberg, , Sweden

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Grycksbo, , Sweden

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Hallstahammar, , Sweden

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Hägersten, , Sweden

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Hässelby, , Sweden

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Hedemora, , Sweden

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Helsingborg, , Sweden

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Henån, , Sweden

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Höllviken, , Sweden

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Jarfalla, , Sweden

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Kil, , Sweden

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Kolbäck, , Sweden

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Kolsva, , Sweden

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Köping, , Sweden

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Leksand, , Sweden

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Lidköping, , Sweden

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Likenäs, , Sweden

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Limhamn, , Sweden

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Ludvika, , Sweden

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Malmo, , Sweden

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Malung, , Sweden

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Mora, , Sweden

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Munka-Ljungby, , Sweden

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Norberg, , Sweden

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Sala, , Sweden

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Säter, , Sweden

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Skanör, , Sweden

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Skepplanda, , Sweden

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Skinnskatteberg, , Sweden

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Skogås, , Sweden

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Skoghall, , Sweden

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Skövde, , Sweden

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Skultuna, , Sweden

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Smedjebacken, , Sweden

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Stockholm, , Sweden

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Stora Höga, , Sweden

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Sunnansjö, , Sweden

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Sunne, , Sweden

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Svärdsjö, , Sweden

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Trollhättan, , Sweden

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Upplands Vasby, , Sweden

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Uppsala, , Sweden

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Vansbro, , Sweden

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Västerås, , Sweden

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Countries

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Sweden

References

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Hasvold LP, Bodegard J, Thuresson M, Stalhammar J, Hammar N, Sundstrom J, Russell D, Kjeldsen SE. Diabetes and CVD risk during angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker treatment in hypertension: a study of 15,990 patients. J Hum Hypertens. 2014 Nov;28(11):663-9. doi: 10.1038/jhh.2014.43. Epub 2014 Jun 26.

Reference Type DERIVED
PMID: 25211055 (View on PubMed)

Other Identifiers

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NIS-CSE-ATA-2010/1

Identifier Type: -

Identifier Source: org_study_id