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Evaluation of Cissus Verticillata L. Infusion in Controlling Type 2 Diabetes

NCT ID: NCT01145534

Last Updated: 2011-11-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1/PHASE2

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-01-31

Study Completion Date

2009-10-31

Brief Summary

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The purpose of this study was to investigate whether the infusion of a medicinal plant (Cissus verticillata L.) would be effective in reducing glucose levels in blood and saliva of type 2 Diabetes patients.

Detailed Description

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Type 2 diabetes mellitus is regarded as one of the most prevalent disease of the adult population. In many developing countries, this condition is regarded as major public health problem. Type 2 diabetes is a metabolic disorder characterized by high blood glucose related with a condition of insulin resistance and relative insulin deficiency. As Diabetes progresses, medications are necessary to control glucose levels.

The aim of this study was to investigate whether the infusion of a medicinal plant (Cissus verticillata L.) would be as effective as a regular drug (glibenclamide) in reducing glucose levels in blood and saliva of type 2 Diabetes patients. Several medicinal plants have been used as potential medication for controlling glucose levels in Diabetes patients. Few studies have explored this effect related to Cissus verticillata L.infusion, though it has been indicated by folk medicine of some Latin American countries.

Conditions

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Diabetes

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Glibenclamide

Patients used 5 mg glibenclamide daily for 60 days

Group Type ACTIVE_COMPARATOR

glibenclamide

Intervention Type DRUG

5 mg as pills, taken daily during the morning for 60 days

Experimental

Patients ingested the infusion of Cissus verticillata L. prepared as 1 g in 150 mL of hot water for 10 min. This was done daily for 60 days

Group Type EXPERIMENTAL

medicinal plant infusion

Intervention Type OTHER

INfusion fo Cissus verticillata L., 1 g in 150 mL water, ingested daily for 60 days.

Interventions

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glibenclamide

5 mg as pills, taken daily during the morning for 60 days

Intervention Type DRUG

medicinal plant infusion

INfusion fo Cissus verticillata L., 1 g in 150 mL water, ingested daily for 60 days.

Intervention Type OTHER

Other Intervention Names

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Glibenclamida, Legrand GE popular plant name: Insulina

Eligibility Criteria

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Inclusion Criteria

* subjects of 30 up to 80 years of age
* positive diagnostic for type 2 diabetes mellitus (blood glucose level above 126 mg/dL)
* patients that signed the informed consent

Exclusion Criteria

* patients with renal and hepatic disfunction,
* patients with cardiac problems or other systemic alterations (allergies, pulmonary and gastrointestinal problems)
* pregnant women
Minimum Eligible Age

30 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Conselho Nacional de Desenvolvimento Científico e Tecnológico

OTHER_GOV

Sponsor Role collaborator

Federal University of Paraíba

OTHER

Sponsor Role lead

Responsible Party

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Federal University of Paraiba

Principal Investigators

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Fabio C Sampaio, PhD

Role: STUDY_CHAIR

Federal University fo Paraiba

Locations

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Centro de Especialidades Odontologicas

Patos, Paraíba, Brazil

Site Status

Countries

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Brazil

Related Links

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http://www.ccs.ufpb.br/gefao/

Official research group for studies related to medicinal plants

Other Identifiers

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UFPB-0346

Identifier Type: -

Identifier Source: org_study_id