Nimotuzumab and Radiotherapy in Pediatric Patients With Glioma

NCT ID: NCT01145170

Last Updated: 2015-07-27

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 40 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2011-03-31
• Study Completion Date: 2014-07-31

Brief Summary

The study consists in only one treatment group, which will receive the first-line therapy for the disease - standard radiotherapy and a 150 mg/m2 dose of the investigational product (nimotuzumab)

Detailed Description

General Purpose

1. To determine the therapeutic efficacy of the treatment with nimotuzumab in combination with radiotherapy in pediatric patients with diffuse intrinsic astrocytic of the brainstem glioma

Specific Purposes

1. To determine the efficacy regarding the event-free survival (EFS) rate by 6 months of treatment.

2. To determine the overall survival time of the patients with diffuse intrinsic astrocytic tumors of the cerebral trunk treated with combined radiotherapy and nimotuzumab.

3. To determine the antitumoral objective response of the patients treated with combined radiotherapy and nimotuzumab.

4. To determine the duration time of the response in the cases of objective response reached (CR or PR) or disease stabilization.

5. To assess the toxicity of the combination AcM h-R3-nimotuzumab and radiotherapy in the patients enrolled in the clinical study.

Conditions

Diffuse Intrinsic Brainstem Gliomas

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Nimotuzumab

The study consists of a single treatment group, which will receive the first-line therapy for the disease. The therapy is the standard radiotherapy and a dose of the investigational product (nimotuzumab) at 150 mg/m2.

Group Type: EXPERIMENTAL

Radiotherapy

Intervention Type: RADIATION

Radiotherapy will be given at the standard dose between 54 and 60 Gy for irradiation of tumors of the central nervous system.

Nimotuzumab

Intervention Type: BIOLOGICAL

The patients will receive the induction therapy for 12 weeks. If the patient reaches a complete, partial response (CR, PR) to the treatment or is at least evaluated as stable disease (SD) on week 12, the consolidation therapy should be initiated. The consolidation therapy will consist of the nimotuzumab administration, every 2 weeks.

Interventions

Radiotherapy

Radiotherapy will be given at the standard dose between 54 and 60 Gy for irradiation of tumors of the central nervous system.

Intervention Type: RADIATION

Nimotuzumab

The patients will receive the induction therapy for 12 weeks. If the patient reaches a complete, partial response (CR, PR) to the treatment or is at least evaluated as stable disease (SD) on week 12, the consolidation therapy should be initiated. The consolidation therapy will consist of the nimotuzumab administration, every 2 weeks.

Intervention Type: BIOLOGICAL

Eligibility Criteria

Inclusion Criteria

1. Pediatric patients with diffuse intrinsic brainstem gliomas, documented by standard imaging techniques (MRI). Note: Tumor biopsy and histological confirmation are not required in this study.

2. Patients eligible for radiotherapy with Cobalt60. The patients should not have received a previous specific oncological treatment.

3. Aged > 3 years old < 18 years old

4. Patients with measurable lesions, defined as those that can be accurately measured in at least 2 dimensions (the 2 largest perpendicular diameters), using standard techniques (MRI).

5. Female patients with childbearing potential should present a negative pregnancy test and adopt effective birth control methods, in case they are sexually active.

6. Male patients who can father a child should adopt effective birth control methods, in case they are sexually active.

7. Life expectancy > 12 weeks

8. Health general status, according to Karnofsky Index > 40% (Karnofsky Index for patients > 16 years old), Lansky > 40% (for patients < 16 years old)

9. Laboratory parameters within the normal limits, defined as: Hematopoietic: Hemoglobin > 10 g/L, Total Leukocytes > 2 x 109 cells/L, Platelets > 100 x 109/L; Hepatic: Liver functioning within the normal limits and without hepatic diseases demonstrated by ALT, AST < 2.5 x above the reference value and Total Bilirubin < 1.5 x above the reference value; Renal function: Serum Creatinine < 1.5 x above the reference value.

10. The parents or legal guardians should express, voluntarily, in writing, that the patient will be enrolled in the study upon signature of the informed consent form. At the investigator's discretion, where applicable, the consent will be obtained from the minor.

Exclusion Criteria

1. Low-grade brainstem glioma (e.g., focal, cervicomedullary, tectal brainstem glioma).

2. Patients previously treated with some AcM.

3. Patients previously treated with some antineoplastic therapy, including chemotherapy, immunotherapy or radiotherapy.

4. Concurrent treatment with some antineoplastic therapy not conceived in the study protocol.

5. Breastfeeding or pregnant patients.

6. Patients that, at the time of enrollment, have some related chronic disease under decompensation (e.g., cardiopathy, diabetes, hypertension).

7. Patients who have history of hypersensitivity to this or another similar product.

8. Fever, severe septic processes and/or severe or acute allergy.

9. Patients who are participating in another clinical study with therapeutic purposes for their disease based on the time of the study enrollment.

10. Presence of a second tumor.

• Minimum Eligible Age: 3 Years
• Maximum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Centro de Immunologia Molecular, Cuba

INDUSTRY

Sponsor Role: collaborator

Eurofarma Laboratorios S.A.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Sidnei Epelman

Role: PRINCIPAL_INVESTIGATOR

Casa de Saúde santa Marcelina

Vicente Odone Filho

Role: PRINCIPAL_INVESTIGATOR

Hospital das Clínicas da Faculda de Medicina da USP

Algemir L Brunetto

Role: PRINCIPAL_INVESTIGATOR

Hospital de Clínicas de Porto Alegre

Claudia T Oliveira

Role: PRINCIPAL_INVESTIGATOR

Hospital Amaral Carvalho

Locations

Hospital de Clínicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, Brazil

Hospital Amaral Carvalho

Jaú, São Paulo, Brazil

Casa de Saúde Santa Marcelina

São Paulo, São Paulo, Brazil

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

São Paulo, São Paulo, Brazil

Hospital Juan Manuel Márquez

Havana, , Cuba

Countries

Brazil; Cuba

Other Identifiers

EF090

Identifier Type: -

Identifier Source: org_study_id