Development of a Biomarker for Dietary Furanocoumarins

NCT ID: NCT01142037

Last Updated: 2014-08-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-10-31

Study Completion Date

2011-02-28

Brief Summary

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Certain plant foods are high in furanocoumarins. Test tube and animal studies suggest that furanocoumarins may help prevent cancer. It is difficult to determine in humans if furanocoumarins do prevent cancer because there isn't an objective way to tell who has eaten these compounds. This study will develop a urine test to determine if an individual ate foods that contain furanocoumarins.

Detailed Description

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Conditions

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Cancer Healthy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Furanocoumarin

Includes participants first refraining from eating foods with furanocoumarins for one week, followed by 2 weeks of increasing furanocoumarin consumption. Participants will be asked to consume cooked parsnips and parsley.

Group Type EXPERIMENTAL

Cooked parsnips with parsley

Intervention Type DIETARY_SUPPLEMENT

Beginning on Day 9 participants will be given cooked parsnips with parsley at a dose of 2 grams total apiaceous vegetable/kilogram body weight for period 1, and 4 gram/kilogram body weight for period 2.

Interventions

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Cooked parsnips with parsley

Beginning on Day 9 participants will be given cooked parsnips with parsley at a dose of 2 grams total apiaceous vegetable/kilogram body weight for period 1, and 4 gram/kilogram body weight for period 2.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Must be at least 18 years of age
* Healthy

Exclusion Criteria

* History of gastrointestinal, hepatic or renal disorder
* Currently taking any prescription or over-the-counter medication
* Currently taking any herbal supplement
* Pregnant or lactating
* Allergies to foods that will be used (parsnips and parsley)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Cancer Institute (NCI)

NIH

Sponsor Role collaborator

University of Minnesota

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Sabrina Peterson, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of Minnesota

Locations

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Department of Food Science and Nutrition, University of Minnesota

Saint Paul, Minnesota, United States

Site Status

Countries

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United States

Other Identifiers

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0909M72358

Identifier Type: OTHER

Identifier Source: secondary_id

1K07CA128952-01A2

Identifier Type: NIH

Identifier Source: secondary_id

View Link

2009NTLS107

Identifier Type: -

Identifier Source: org_study_id

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