The Electroretinogram in Healthy and Glucose Intolerant Young Men
NCT ID: NCT01140932
Last Updated: 2010-12-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
10 participants
INTERVENTIONAL
2010-02-28
2010-06-30
Brief Summary
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Detailed Description
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Each subject is examined twice on two different days. The first day the subjects are normoglycaemic in the morning (first examination) and hyperglycaemic (clamped to 10 mM) throughout the second examination. The second day subjects are also normoglycaemic and hyperglycaemic but shows up after 7-12 days of daily intake of prednisolone, high calorie diet, and exercise restraint.
Conditions
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Keywords
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Study Design
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NON_RANDOMIZED
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Intervention
Medical and behavioural intervention
Prednisolone
12 days of corticosteroids treatment (prednisolone 37,5 mg/day)
Lifestyle change
High calorie diet (130 % of recommended daily energy intake) and relative physical inactivity (no exercise and at least 8 hours of rest/day)
Interventions
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Prednisolone
12 days of corticosteroids treatment (prednisolone 37,5 mg/day)
Lifestyle change
High calorie diet (130 % of recommended daily energy intake) and relative physical inactivity (no exercise and at least 8 hours of rest/day)
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Normal OGTT (75 g glucose dissolved in 250 mL water) according to WHO's criteria
* BMI 20-30
* Haemoglobin \> 8,0 mM
Exclusion Criteria
* Relatives (parents or sibling with T2DM)
* Medical treatment which cannot be paused for 12 hours
18 Years
35 Years
MALE
Yes
Sponsors
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Glostrup University Hospital, Copenhagen
OTHER
Responsible Party
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Glostrup University Hospital,Copenhagen
Principal Investigators
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Michael Larsen, MD, DMsc
Role: PRINCIPAL_INVESTIGATOR
Glostrup University Hospital, Copenhagen
Locations
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Copenhagen University Hospital at Glostrup
Copenhagen, Copenhagen, Denmark
Countries
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Other Identifiers
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Kappelgaard, ERG
Identifier Type: -
Identifier Source: org_study_id