Kidney Damage in Patients With Moderate Fall in eGFR

NCT ID: NCT01136876

Last Updated: 2020-11-04

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

57 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-11-30

Study Completion Date

2012-11-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

To compare Iopamidol injection 370 and Iodixanol 320 in evaluating Neutrophil Gelatinase-Associated Lipocalin (NGAL) in patients with moderate fall in eGFR

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This is a pilot study having a randomized, double-blind parallel group comparison of two iodinated contrast agents used during percutaneous coronary intervention (PCI). All patients enrolled must have eGFR greater than or equal to 30 mL/min and less than or equal to 59 mL/min. Statistical summaries will be presented to analyze the various lab tests results for the two groups.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Coronary Artery Stenosis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Iopamidol

Non-ionic low-osmolar iodinated contrast media

Group Type ACTIVE_COMPARATOR

Iopamidol

Intervention Type DRUG

Iopamidol 370, one time administration for percutaneous coronary intervention

Iodixanol

Non-ionic iso-osmolar iodinated contrast media comparator

Group Type ACTIVE_COMPARATOR

Iodixanol-320

Intervention Type DRUG

Iodixanol-320 single administration for percutaneous coronary intervention procedure

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Iopamidol

Iopamidol 370, one time administration for percutaneous coronary intervention

Intervention Type DRUG

Iodixanol-320

Iodixanol-320 single administration for percutaneous coronary intervention procedure

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Isovue-370 Visipaque 320

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* At least 18 years of age and provides informed consent
* Scheduled to undergo percutaneous coronary intervention
* Documented pre-dose Estimated glomerular filtration rate (eGFR) of greater than or equal to 30 mL/min/1.73 m squared and less than or equal to 59 mL/min/1.73 m squared

Exclusion Criteria

* Pregnant or lactating females
* Severe congestive heart failure
* History of hyperthyroidism;
* Unstable renal function
* Emergency PCI
* History of hypersensitivity to iodinated contrast agents
* Receiving diuretics to prevent acute renal injury
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Bracco Diagnostics, Inc

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Maria Luigia Storto, MD

Role: STUDY_DIRECTOR

Bracco Diagnostics, Inc

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Research Cooperative, St. John's Hospital

Springfield, Illinois, United States

Site Status

UMDNJ - RWJ Medical School

New Brunswick, New Jersey, United States

Site Status

The Institute for Clinical Research at Holy Name Medical Center

Teaneck, New Jersey, United States

Site Status

Montreal Heart Institute

Montreal, Quebec, Canada

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States Canada

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

IOP-117

Identifier Type: -

Identifier Source: org_study_id