Effects of PAP Treatment of OSA in Patients With Heart Failure

NCT ID: NCT01136122

Last Updated: 2025-10-20

Basic Information

• Recruitment Status: WITHDRAWN
• Clinical Phase: NA
• Study Classification: INTERVENTIONAL
• Study Start Date: 2010-04-30
• Study Completion Date: 2013-10-31

Brief Summary

The purpose of this study is to see if treatment of OSA with the CPAP device makes a difference to insulin resistance and heart disease.

Detailed Description

Obstructive Sleep Apnea (OSA) has been seen frequently in persons who develop insulin resistance and heart disease. Insulin resistance is a condition in which the body produces insulin but does not use it properly. Insulin helps the body use glucose for energy. Insulin resistance increases the chance of developing type II diabetes and heart disease.

One method of treatment for OSA is with continuous positive airway pressure (CPAP). This treatment is given by a device named CPAP. There are many different types of CPAPs available on the market that are FDA approved.

The purpose of this study is to see if treatment of OSA with the CPAP device makes a difference to insulin resistance and heart disease. This study will measure insulin resistance by testing the glucose level in the blood, and testing the levels of special protein found in blood, that are known to increase the sensitivity to insulin and decrease progression of heart disease. The heart disease will be measured by cardiac MRI. Glucose testing and cardiac MRI's are normal testing procedures for people who have OSA and heart disease, however will be conducted more frequently than normal and therefore are for research purposes. The specialized blood testing is for research purposes only.

Conditions

Obstructive Sleep Apnea

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: SINGLE

Study Groups

CPAP Arm

Receive effective CPAP treatment for one month

Group Type: ACTIVE_COMPARATOR

CPAP Treatment

Intervention Type: DEVICE

Effective CPAP treatment for one month

Control Arm

Receive no treatment for one month

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

CPAP Treatment

Effective CPAP treatment for one month

Intervention Type: DEVICE

Other Intervention Names

CPAP

Eligibility Criteria

Inclusion Criteria

• 18 and < 75 years of age.
• Apnea-hypopnea index (AHI) of at least 15/hr based on overnight polysomnography.
• New York Heart Association Class 3 or less.
• LV ejection fraction <45% based on a prior imaging study (as measured within one year of baseline studies).
• Absence of exacerbation of heart failure requiring hospitalization within the previous 3 mos.
• Optimal pharmacologic therapy at the highest tolerated dose [3].

Exclusion Criteria

• Use of anti-diabetic medications
• Primary valvular heart disease
• Unstable angina
• Myocardial infarction, cardiac surgery, or revascularization procedure within the previous 3 months
• Uncontrolled hypertension defined as systolic blood pressure >160 mm Hg or diastolic blood pressure >100 mm Hg.
• Active smoking (Patient should not have smoked for at least 1 month prior to baseline studies and has the intention not to smoke for the duration of the study period)
• Use of illicit drugs
• Current use of home oxygen therapy
• Requirement for a bi-level machine to treat sleep apnea
• Use of corticosteroids
• Creatinine clearance < 30ml/min (calculated from serum creatinine)
• Pregnant women will be excluded as pregnancy interferes with glucose and adiponectin. Additionally the contrast used in the cardiac MRIs may be harmful to unborn babies. Females of child bearing potential must agree to use effective contraception during the trial.
• Any contraindication to CMR (Cardiovascular magnetic resonance) imaging such as ferromagnetic foreign body, orbital metal, cerebral aneurysm clip, pacemaker, defibrillator, neurostimulator, allergy to gadolinium-based contrast, or severe claustrophobia. The standard FDA and OSUMC's screening guidelines for MRI safety will be followed.
• Inability or unwillingness to provide consent

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Ulysses Magalang MD

OTHER

Sponsor Role: lead

Responsible Party

Ulysses Magalang MD

Medical Director, Sleep Medicine-East

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Ulysses Magalang, M.D.

Role: PRINCIPAL_INVESTIGATOR

Ohio State University

Locations

The Ohio State University Medical Center

Columbus, Ohio, United States

Countries

United States

Other Identifiers

2009H0304

Identifier Type: -

Identifier Source: org_study_id