Bioequivalence Study of Dr.Reddy's Laboratories Limited Finasteride Tablets 1 mg Under Fed Condition

NCT ID: NCT01133457

Last Updated: 2010-05-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2002-04-30

Study Completion Date

2002-05-31

Brief Summary

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The objective of this study was to compare the single-dose relative bioavailability of Dr. Reddy's Laboratories, Ltd. and Merck \& Co. (Propecia®)

1 mg finasteride tablets under fed conditions following administration of a 3 mg dose.

Detailed Description

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Detailed Description : The study was conducted as an open-label, randomized, single-dose, 2-way crossover, relative bioavailability study performed on 24 healthy adult male volunteers and 2 alternates. A total of 24 subjects completed the clinical phase of the study. In each period, subjects were housed from the evening before dosing until after the 36-hour blood draw. Single oral 3 mg doses were separated by a washout period of 7 days.

Conditions

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Healthy

Keywords

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Bioequivalence,Finasteride,Crossover

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Finasteride

Finasteride tablets 1 mg of Dr. Reddy's

Group Type EXPERIMENTAL

Finasteride

Intervention Type DRUG

Finasteride tablets 1 mg

Propecia

Propecia 1 mgTablets of Merck \& Co.,

Group Type ACTIVE_COMPARATOR

Finasteride

Intervention Type DRUG

Finasteride tablets 1 mg

Interventions

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Finasteride

Finasteride tablets 1 mg

Intervention Type DRUG

Other Intervention Names

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Propecia

Eligibility Criteria

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Exclusion Criteria

History or presence of significant:

• cardiovascular, pulmonary, hepatic, renal, hematologic, gastrointestinal, endocrine, immunologic, dermatologic, neurologic or psychiatric disease.

In addition, history or presence of:

* alcoholism or drug abuse within the past year;
* hypersensitivity or idiosyncratic reaction to finasteride or any other 5-a reductase inhibitor.

Subjects who have been on an abnormal diet (for whatever reason) during the 28 days preceding the study.

Subjects who, through completion of the study, would have donated in excess of:

* 500 mL of blood in 14 days, or
* 500 - 750 mL of blood in 14 days (unless approved by the Principal Investigator),
* 1000 mL of blood in 90 days,
* 1250 mL of blood in 120 days,
* 1500 mL of blood in 180 days,
* 2000 mL of blood in 270 days,
* 2500 mL of blood in 1 year. Subjects who have participated in another clinical trial within 28 days prior to the first dosing.
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Dr. Reddy's Laboratories Limited

INDUSTRY

Sponsor Role lead

Responsible Party

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Dr. Reddy's Laboratories Limited

Principal Investigators

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Gaetano Morelli, MD

Role: PRINCIPAL_INVESTIGATOR

MDS Pharma Services

Locations

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MDS Pharma Services

Cohen Street, Saint-laurent, Montreal (quebec), , Canada

Site Status

Countries

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Canada

Other Identifiers

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012744

Identifier Type: -

Identifier Source: org_study_id