A Scandinavian Non-interventional Study of Adherence to RebiSmart Administered Rebif New Formulation (RNF) Treatment in Relapsing Remitting Multiple Sclerosis (RRMS) Subjects

NCT ID: NCT01125475

Last Updated: 2014-07-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

61 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-08-31

Brief Summary

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The primary objective is to determine adherence to Rebif® New Formulation administered by RebiSmart during 12 weeks of therapy in patients with RRMS.

Detailed Description

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Conditions

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Relapsing Remitting Multiple Sclerosis (RRMS)

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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RebiSmart

Treatment with Rebif New Formulation using RebiSmart.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Males and females between 18 and 65 years of age
* Have relapsing-remitting multiple sclerosis (RRMS) according to the revised McDonald Criteria (2005)
* Having an expanded disability status scale (EDSS) of less than 6 at the screening visit or within 2 months prior to the screening visit
* Stable treatment (defined as treatment after titration period) with RebiSmart administered Rebif new formulation (RNF) 22/44 mcg subcutaneously thrice a week for a minimum of 4 weeks prior to inclusion
* Previously treated with disease modifying drugs (DMDs) for a minimum of 6 months prior to the screening visit
* Female subjects must be neither pregnant nor breast-feeding and must lack child-bearing potential as defined by either:

* Post-menopausal or surgically sterile; or
* Using a highly effective method of contraception for the duration of the study. This is defined as a method that results in a low failure rate (i.e. less than 1% per year) when used consistently and correctly , and includes for instance implants, injectables, combined oral contraceptives, intra-uterine device (IUD), sexual abstinence or vasectomized partner
* Have a scheduled visit 12 weeks after the inclusion visit
* Willing and able to comply with the protocol for the duration of the study
* Have given written informed consent

Exclusion Criteria

* Have had a relapse within 30 days prior to the first visit
* Have any contra-indications to treatment with Interferon-beta 1a according to Summary of Product Characteristics
* Have any other significant disease that in the Investigator's opinion would exclude the subject from the trial
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Merck Serono Norway

INDUSTRY

Sponsor Role collaborator

Smerud Medical Research International AS

OTHER

Sponsor Role collaborator

Merck KGaA, Darmstadt, Germany

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Medical Director

Role: STUDY_DIRECTOR

Merck Serono Norway

Locations

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Sandvika Nevrosenter

Sandvika, Sandviksveien 178, Norway

Site Status

Countries

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Norway

Other Identifiers

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EMR 701068-521

Identifier Type: -

Identifier Source: org_study_id

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