Clinical Study Of Eplerenone In Japanese Patients With Chronic Heart Failure

NCT ID: NCT01115855

Last Updated: 2020-12-22

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

221 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-07-31

Study Completion Date

2015-09-30

Brief Summary

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A study to compare the efficacy and safety of eplerenone in Japanese chronic heart failure patients with placebo.

Detailed Description

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The aim of this study was to show consistency with the EMPHASIS-HF trial (NCT00232180), which was defined as a HR of the primary endpoint of below 1.

Conditions

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Heart Failure

Keywords

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Double-blind eplerenone Japanese

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Eplerenone arm

Add on standard heart failure therapy

Group Type EXPERIMENTAL

Eplerenone

Intervention Type DRUG

Eplerenone 25 mg once every other day, 25mg once daily or 50 mg once daily

Placebo arm

Add on standard heart failure therapy

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo once daily or every once daily

Interventions

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Eplerenone

Eplerenone 25 mg once every other day, 25mg once daily or 50 mg once daily

Intervention Type DRUG

Placebo

Placebo once daily or every once daily

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Japanese chronic systolic heart failure patients with LVEF =\<30% by echocardiography and NYHA II or more
* Patients who receive standard therapy (Angiotensin converting enzyme inhibitors, angiotensin receptor blockers, beta-blocker or diuretic)

Exclusion Criteria

* Patients with a myocardial infarction, stroke, cardiac surgery or percutaneous coronary intervention within 30 days prior to randomization.
* Patients with serum potassium \>5.0 mmol/L or eGFR \<30 ml/min/1.73 m2.
Minimum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Chubu Rosai Hospital

Nagoya, Aichi-ken, Japan

Site Status

Tosei General Hospital

Seto, Aichi-ken, Japan

Site Status

Asahi General Hospital

Asahi, Chiba, Japan

Site Status

National Hospital Organization Chiba Medical Center

Chiba, Chiba, Japan

Site Status

Nippon Medical School Chiba Hokusou Hospital

Inzai, Chiba, Japan

Site Status

Ehime Prefectural Central Hospital

Matuyama-shi, Ehime, Japan

Site Status

Kyushu University Hospital

Fukuoka, Fukuoka, Japan

Site Status

Aso Iizuka Hospital

Iizuka-shi, Fukuoka, Japan

Site Status

Kurume University Hospital

Kurume-shi, Fukuoka, Japan

Site Status

Southern TOHOKU Research Institute for Neuroscience Southern TOHOKU Medical Clinic

Kōriyama, Fukushima, Japan

Site Status

Ogaki Municipal Hospital

Ōgaki, Gifu, Japan

Site Status

National Hospital Organization Hakodate National Hospital

Hakodate-shi, Hokkai-do, Japan

Site Status

Hakodate City Hospital

Hakodate, Hokkaido, Japan

Site Status

Teine Keijinkai Clinic

Sapporo, Hokkaido, Japan

Site Status

Hokkaido University Hospital

Sapporo, Hokkaido, Japan

Site Status

National Hospital Organization Hokkaido Medical Center

Sapporo, Hokkaido, Japan

Site Status

Hyogo Brain and Heart Center

Himeji, Hyōgo, Japan

Site Status

Japanease Red Cross Society Himeji Hospital

Himeji, Hyōgo, Japan

Site Status

The Hospital of Hyogo College of Medicine

Nishinomiya, Hyōgo, Japan

Site Status

Toride Kyodo General Hospital

Toride-shi, Ibaraki, Japan

Site Status

Mitoyo General Hospital

Kan’onjichō, Kagawa-ken, Japan

Site Status

Fujisawa City Hospital

Fujisawa, Kanagawa, Japan

Site Status

Kitasato University Hospital

Sagamihara, Kanagawa, Japan

Site Status

Mie University Hospital

Tsu, Mie-ken, Japan

Site Status

National Hospital Organization Sendai Medical Center

Sendai, Miyagi, Japan

Site Status

Nara Medical University Hospital

Kashihara, Nara, Japan

Site Status

Kishiwada Tokushukai Hospital

Kishiwada, Osaka, Japan

Site Status

Sakai City Medical Center

Sakai-shi, Osaka, Japan

Site Status

National Cerebral and Cardiovascular Center Hospital

Suita-shi, Osaka, Japan

Site Status

Gokeikai Osaka Kaisei Hospital

Yodogawa-ku, Osaka, Japan

Site Status

Shuwa General Hospital

Kasukabe-shi, Saitama, Japan

Site Status

Saitama Medical Center Jichi Medical University

Saitama-shi, Saitama, Japan

Site Status

Kusatsu General Hospital

Kusatsu-shi, Shiga, Japan

Site Status

Hamamatsu Rosai Hospital

Hamamatsu, Shizuoka, Japan

Site Status

Jichi Medical University Hospital

Shimotsuke-shi, Tochigi, Japan

Site Status

Tokushima Red Cross Hospital

Komatsushimachō, Tokushima, Japan

Site Status

Juntendo University Hospital

Bunkyo-ku, Tokyo, Japan

Site Status

Mitsui Memorial Hospital

Chiyoda-Ku, Tokyo, Japan

Site Status

Tokyo Women's Medical University Hospital

Shinjuku-ku, Tokyo, Japan

Site Status

Tottori University Hospital

Yonago-shi, Tottori, Japan

Site Status

Ube-kohsan Central Hospital Corp.

Ube, Yamaguchi, Japan

Site Status

Yamaguchi University Hospital

Ube, Yamaguchi, Japan

Site Status

University of Yamanashi Hospital

Chūō, Yamanashi, Japan

Site Status

Hamanomachi Hospital

Fukuoka, , Japan

Site Status

Fukushima Medical University Hospital

Fukushima, , Japan

Site Status

Gifu Prefectural General Medical Center

Gifu, , Japan

Site Status

Kumamoto University Hospital

Kumamoto, , Japan

Site Status

Saiseikai Kumamoto Hospital

Kumamoto, , Japan

Site Status

Japanese Red Cross Okayama Hospital

Okayama, , Japan

Site Status

National Hospital Organization Osaka National Hospital

Osaka, , Japan

Site Status

Osaka Police Hospital

Osaka, , Japan

Site Status

Osaka General Medical Center

Osaka, , Japan

Site Status

National Hospital Organization Takasaki General Medical Center

Takasaki-shi, , Japan

Site Status

Toyama University Hospital

Toyama, , Japan

Site Status

Countries

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Japan

References

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Tsutsui H, Ito H, Kitakaze M, Komuro I, Murohara T, Izumi T, Sunagawa K, Yasumura Y, Yano M, Yamamoto K, Yoshikawa T, Tsutamoto T, Zhang J, Okayama A, Ichikawa Y, Kanmuri K, Matsuzaki M; J-EMPHASIS-HF Study Group. Double-Blind, Randomized, Placebo-Controlled Trial Evaluating the Efficacy and Safety of Eplerenone in Japanese Patients With Chronic Heart Failure (J-EMPHASIS-HF). Circ J. 2017 Dec 25;82(1):148-158. doi: 10.1253/circj.CJ-17-0323. Epub 2017 Aug 19.

Reference Type DERIVED
PMID: 28824029 (View on PubMed)

Other Identifiers

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A6141114

Identifier Type: -

Identifier Source: org_study_id