Non-interventional Study (NIS) in Patients With Restless Legs Syndrome in Daily Practise

NCT ID: NCT01113710

Last Updated: 2012-09-28

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

687 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-05-31

Study Completion Date

2011-07-31

Brief Summary

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This non-interventional observational study is designed to gain data for Neupro® in restless legs syndrome (RLS) under real life conditions in line with the summary of product characteristics (SmPC) related to effectiveness, tolerability and switching practice from other dopaminergic drugs as well as titration schemes.

Detailed Description

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There is a total of 64 subjects recorded as having discontinued due to Adverse Events. Documentation of Visit 2 and Visit 3, where the reason for discontinuation was documented, was not available for all subjects. From the documentation on the Adverse Events page in the Case Report Form, it is known that 100 subjects discontinued due to Adverse Events.

The Last Observation Carried Forward (LOCF) method was utilized for all outcomes.

Conditions

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Idiopathic Restless Legs Syndrome

Keywords

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Rotigotine Neupro® Restless Legs Syndrome

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Neupro®

Routine treatment in accordance with the local marketing authorization for Neupro® in RLS

Neupro®

Intervention Type DRUG

Neupro® is the exposure/intervention of interest in this non-interventional study.

Interventions

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Neupro®

Neupro® is the exposure/intervention of interest in this non-interventional study.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* It was recommended that the patient's treatment was in accordance with the local marketing authorization (MA) for Neupro®
* The patient must have a diagnosis of moderate to severe idiopathic RLS
* The patient is considered reliable and capable of adhering to the visit schedule or medication administration according to the judgment of the investigator
* The decision to prescribe the drug has been made by the physician independently of his/her decision to include the patient in the study
* Subject is informed and given ample time and opportunity to think about his/her participation in the study and has given written informed data consent

Exclusion Criteria

* Hypersensitivity to the active substance or to any of the excipients
* Magnetic resonance imaging or cardioversion (see SmPC)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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UCB Pharma

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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UCB Clinical Trial Call Center

Role: STUDY_DIRECTOR

+1 877 822 9493 (UCB)

Locations

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Abensburg, , Germany

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Altenholz, , Germany

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Alzenau in Unterfranken, , Germany

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Anklam, , Germany

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Aschaffenburg, , Germany

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Bad Neustadt an der Saale, , Germany

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Berlin, , Germany

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Bielefeld, , Germany

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Bischofswerda, , Germany

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Bochum, , Germany

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Bonn, , Germany

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Böblingen, , Germany

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Bremen, , Germany

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Cologne, , Germany

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Cottbus, , Germany

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Delbrück, , Germany

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Dippoldiswalde, , Germany

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Dortmund-Kirchhörde, , Germany

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Dresden, , Germany

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Düren, , Germany

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Ellwangen, , Germany

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Erbach im Odenwald, , Germany

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Freiburg im Breisgau, , Germany

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Fulda, , Germany

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Gelsenkirchen, , Germany

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Gera, , Germany

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Gladenbach, , Germany

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Göttingen, , Germany

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Greifswald, , Germany

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Gütersloh, , Germany

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Halle, , Germany

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Heidenheim, , Germany

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Ilmenau, , Germany

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Jülich, , Germany

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Karlsruhe, , Germany

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Karlstadt am Main, , Germany

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Kassel, , Germany

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Kaufbeuren, , Germany

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Kleve, , Germany

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Königsbrück, , Germany

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Leipzig, , Germany

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Lemgo, , Germany

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Leun-Biskirchen, , Germany

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Lippstadt, , Germany

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Lohr a. Main, , Germany

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Ludwigsfelde, , Germany

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Malchin, , Germany

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Mannheim, , Germany

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Marburg, , Germany

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Marburg-Cappel, , Germany

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München, , Germany

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Neuburg an der Donau, , Germany

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Neusäß, , Germany

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Oberursel, , Germany

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Oelde, , Germany

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Osnabrück, , Germany

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Osterode am Harz, , Germany

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Paderborn, , Germany

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Potsdam, , Germany

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Remscheid, , Germany

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Rheda-Wiedenbrück, , Germany

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Rostock, , Germany

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Schriesheim, , Germany

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Schwalmstadt-Treysa, , Germany

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Schwäbisch Gmünd, , Germany

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Schwedt, , Germany

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Schwerin, , Germany

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Senftenberg, , Germany

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Soest, , Germany

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Stadtroda, , Germany

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Stralsund, , Germany

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Stuttgart, , Germany

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Teupitz, , Germany

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Ulm, , Germany

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Westerstede, , Germany

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Wiesbaden, , Germany

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Wismar, , Germany

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Wolfsburg, , Germany

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Zschadrass, , Germany

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Zwickau, , Germany

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Countries

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Germany

References

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Stiasny-Kolster K, Berg D, Hofmann WE, Berkels R, Grieger F, Lauterbach T, Schollmayer E, Bachmann CG. Effectiveness and tolerability of rotigotine transdermal patch for the treatment of restless legs syndrome in a routine clinical practice setting in Germany. Sleep Med. 2013 Jun;14(6):475-81. doi: 10.1016/j.sleep.2013.02.013. Epub 2013 May 11.

Reference Type DERIVED
PMID: 23668924 (View on PubMed)

Other Identifiers

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SP0948

Identifier Type: -

Identifier Source: org_study_id