The Effect of Enhanced External Counter Pulsation on Left Ventricular Systolic and Diastolic Function
NCT ID: NCT01112163
Last Updated: 2010-04-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
20 participants
INTERVENTIONAL
2010-03-31
2010-11-30
Brief Summary
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The aim of the investigators study is to understand the effect of EECP on left ventricular systolic and diastolic function assessed by trans-thoracic echocardiography (TTE).
Hypothesis: EECP improves left ventricular systolic and diastolic function. There is a relationship between d/s ratio and aortic arterial stiffness EECP improves left ventricular diastolic function Standard TTE would be performed prior the EECP procedure, which lasts 60 min., and repeated every 15 minutes. Moreover the investigators would measure pulse wave velocity, a measure of aortic arterial stiffness, in order to investigate the relationship between the d/s ratio and arterial stiffness.
The patients would be recruited among former study patients who have undergone EECP before. 20 patients with the best acoustic conditions would be selected and invited to enroll into the study.
Detailed Description
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Conditions
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Keywords
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Enhanced external counter pulsation
One session of enhanced external counter pulsation (60 minutes)
Enhanced external counter pulsation
While an individual is undergoing ECP, they have pneumatic stockings (also known as cuffs) on their legs and are connected to telemetry monitors that monitor their heart rate and rhythm.The cuffs should ideally inflate at the beginning of diastole and deflate at the beginning of systole. During the inflation portion of the cycle, the calf cuffs inflate first, then the lower thigh cuffs and finally the upper thigh cuffs. Inflation is controlled by a pressure monitor, and the cuffs are inflated to about 300 mmHg.
Interventions
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Enhanced external counter pulsation
While an individual is undergoing ECP, they have pneumatic stockings (also known as cuffs) on their legs and are connected to telemetry monitors that monitor their heart rate and rhythm.The cuffs should ideally inflate at the beginning of diastole and deflate at the beginning of systole. During the inflation portion of the cycle, the calf cuffs inflate first, then the lower thigh cuffs and finally the upper thigh cuffs. Inflation is controlled by a pressure monitor, and the cuffs are inflated to about 300 mmHg.
Eligibility Criteria
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Inclusion Criteria
* Reversal ischemia
* Pathological coronary angiogram without the possibility of revascularization
* Sinus rhythm
Exclusion Criteria
* Dementia
* Pregnancy
* Blood pressure \> 180/110
* Severe valvular disease
* Ejection fraction \< 25%
* Acute coronary syndrome the last 3 months
* History of aortic aneurism
* Pacemaker
* Diabetes mellitus
* Cardiac arrythmia that prevents the EECP procedure
* Bleeding
* Active venous thrombosis
18 Years
80 Years
ALL
No
Sponsors
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Herning Hospital
OTHER
Responsible Party
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Hospitalenheden Vest
Principal Investigators
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Ashkan Eftekhari, MD PhD
Role: PRINCIPAL_INVESTIGATOR
Regionshospitalet Herning / Dept. Pharmacology Aarhus University
Ole May, MD PhD
Role: STUDY_CHAIR
Herning Hospital
Locations
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Regionshospitalet Herning
Herning, , Denmark
Countries
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References
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May O, Sogaard HJ. Enhanced External Counterpulsation Is an Effective Treatment for Depression in Patients With Refractory Angina Pectoris. Prim Care Companion CNS Disord. 2015 Aug 20;17(4):10.4088/PCC.14m01748. doi: 10.4088/PCC.14m01748. eCollection 2015.
Other Identifiers
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EECP-VV
Identifier Type: -
Identifier Source: org_study_id