PhrenIc Nerve mappinG and Stimulation EP Catheter Study: PING-EP Study

NCT ID: NCT01109641

Last Updated: 2010-10-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-02-28

Study Completion Date

2010-10-31

Brief Summary

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The PING-EP study is designed to evaluate electrode properties on phrenic nerve stimulation (PNS) in coronary sinus using a commercially available diagnostic electrophysiology catheter.

Detailed Description

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Conditions

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Heart Failure

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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diagnostic electrophysiology catheter

electrical measurements through a diagnostic electrophysiology catheter

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Subject is indicated for a cardiac resynchronization therapy-pacemaker or defibrillator (CRT-P/CRT-D) implant, for an upgrading from a previously implanted single/dual chamber pacemaker/implantable cardioverter (ICD) or for system revision requiring repositioning of the transvenous left ventricular (LV) lead
* Patient has signed and dated the study-specific Patient Informed Consent form
* Subject is at least 18 years of age

Exclusion Criteria

* Patient has a previous LV lead implanted not requiring repositioning
* Pregnant woman
* Patient is enrolled or planning to participate in any concurrent study, which would confound the results of this trial as determined by Medtronic, during the course of this clinical study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Medtronic Italia

INDUSTRY

Sponsor Role lead

Responsible Party

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Medtronic Italia

Principal Investigators

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Mauro Biffi

Role: PRINCIPAL_INVESTIGATOR

Policlinico S. Orsola Malpighi, Bologna, Italy

Francesco Zanon

Role: PRINCIPAL_INVESTIGATOR

Ospedale S. Maria della Misericordia, Rovigo, Italy

Luigi Padeletti

Role: PRINCIPAL_INVESTIGATOR

Azienda ospedaliero-universitaria Careggi, Firenze, Italy

Manuel Bertaglia

Role: PRINCIPAL_INVESTIGATOR

Azienda Unità Socio Sanitaria di Dolo Mirano, Mirano (VE), Italy

Locations

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Azienda Ospedaliero-Universitana di Bologna, Policlinico S. Orsola Malpighi

Bologna, Bologna, Italy

Site Status

Azienda Ospedaliero-universitaria Careggi

Florence, Firenze, Italy

Site Status

Ospedale S. Maria della Misericordia

Rovigo, Rovigo, Italy

Site Status

Azienda Unità Socio Sanitaria di Dolo Mirano

Mirano, Venezia, Italy

Site Status

Countries

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Italy

References

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McAlister FA, Ezekowitz J, Hooton N, Vandermeer B, Spooner C, Dryden DM, Page RL, Hlatky MA, Rowe BH. Cardiac resynchronization therapy for patients with left ventricular systolic dysfunction: a systematic review. JAMA. 2007 Jun 13;297(22):2502-14. doi: 10.1001/jama.297.22.2502.

Reference Type BACKGROUND
PMID: 17565085 (View on PubMed)

Gurevitz O, Nof E, Carasso S, Luria D, Bar-Lev D, Tanami N, Eldar M, Glikson M. Programmable multiple pacing configurations help to overcome high left ventricular pacing thresholds and avoid phrenic nerve stimulation. Pacing Clin Electrophysiol. 2005 Dec;28(12):1255-9. doi: 10.1111/j.1540-8159.2005.00265.x.

Reference Type BACKGROUND
PMID: 16403156 (View on PubMed)

Albertsen AE, Nielsen JC, Pedersen AK, Hansen PS, Jensen HK, Mortensen PT. Left ventricular lead performance in cardiac resynchronization therapy: impact of lead localization and complications. Pacing Clin Electrophysiol. 2005 Jun;28(6):483-8. doi: 10.1111/j.1540-8159.2005.40066.x.

Reference Type BACKGROUND
PMID: 15955178 (View on PubMed)

Alonso C, Leclercq C, d'Allonnes FR, Pavin D, Victor F, Mabo P, Daubert JC. Six year experience of transvenous left ventricular lead implantation for permanent biventricular pacing in patients with advanced heart failure: technical aspects. Heart. 2001 Oct;86(4):405-10. doi: 10.1136/heart.86.4.405.

Reference Type BACKGROUND
PMID: 11559679 (View on PubMed)

Knight BP, Desai A, Coman J, Faddis M, Yong P. Long-term retention of cardiac resynchronization therapy. J Am Coll Cardiol. 2004 Jul 7;44(1):72-7. doi: 10.1016/j.jacc.2004.03.054.

Reference Type BACKGROUND
PMID: 15234410 (View on PubMed)

Ellery S, Paul V, Prenner G, Tscheliessnigg K, Merkely B, Malinowski K, Frohlig G, Hintringer F, Bosse O, Diotallevi P, Ravazzi AP, Flathmann H, Danilovic D, Unterberg-Buchwald C; OVID Study Investigators. A new endocardial "over-the-wire" or stylet-driven left ventricular lead: first clinical experience. Pacing Clin Electrophysiol. 2005 Jan;28 Suppl 1:S31-5. doi: 10.1111/j.1540-8159.2005.00084.x.

Reference Type BACKGROUND
PMID: 15683519 (View on PubMed)

Matsumoto Y, Krishnan S, Fowler SJ, Saremi F, Kondo T, Ahsan C, Narula J, Gurudevan S. Detection of phrenic nerves and their relation to cardiac anatomy using 64-slice multidetector computed tomography. Am J Cardiol. 2007 Jul 1;100(1):133-7. doi: 10.1016/j.amjcard.2007.01.072. Epub 2007 May 21.

Reference Type BACKGROUND
PMID: 17599455 (View on PubMed)

Other Identifiers

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MDT-PINGEP

Identifier Type: -

Identifier Source: org_study_id