Epoprostenol for Injection in Pulmonary Arterial Hypertension - Extension of AC-066A401

NCT ID: NCT01105117

Last Updated: 2012-12-03

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

2 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-05-31

Study Completion Date

2011-12-31

Brief Summary

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This is an open-label, non-randomized extension to study AC-066A401. The study will assess safety and tolerability of ACT-385781A and Flolan (epoprostenol sodium) while providing a means for continuing treatment after ending participation in study AC-0066A401.

Detailed Description

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Conditions

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Pulmonary Arterial Hypertension

Keywords

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Pulmonary Arterial Hypertension PAH EPITOME-1

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

ACT-385781A (Actelion Epoprostenol)

Group Type ACTIVE_COMPARATOR

ACT-385781A (Actelion Epoprostenol)

Intervention Type DRUG

per Prescribing Information

2

Flolan®

Group Type ACTIVE_COMPARATOR

Flolan®

Intervention Type DRUG

per Prescribing Information

Interventions

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ACT-385781A (Actelion Epoprostenol)

per Prescribing Information

Intervention Type DRUG

Flolan®

per Prescribing Information

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. Signed informed consent prior to initiation of any study-mandated procedure
2. Patients who completed participation in study AC-066A401
3. Patients who have not obtained authorization for commercial ACT-385781 and Flolan at the time of ending participation in study AC-066A401

Exclusion Criteria

1. Patients who prematurely discontinued study drug in study AC-066A401
2. Patients for whom continued treatment with either ACT-385781 and Flolan is no longer considered appropriate
3. Known hypersensitivity to the investigational drug or comparative drug or drugs of the same class, or any of their excipients
4. Any known factor or disease that might interfere with treatment compliance, study conduct or interpretation of the results such as drug or alcohol dependence or psychiatric disease
5. Known concomitant life-threatening disease with a life expectancy \< 12 months
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Actelion

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Wade Benton, PharmD

Role: STUDY_DIRECTOR

Actelion

Locations

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University of California - San Diego

La Jolla, California, United States

Site Status

University of Colorado - Denver

Aurora, Colorado, United States

Site Status

Duke University Medical Center

Durham, North Carolina, United States

Site Status

University of Pennsylvania-Penn Presybyterian Medical Center

Philadelphia, Pennsylvania, United States

Site Status

Vanderbilt Medical Center

Nashville, Tennessee, United States

Site Status

University of Texas Southwestern Medical Center

Dallas, Texas, United States

Site Status

Baylor College of Medicine

Houston, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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AC-066A402

Identifier Type: -

Identifier Source: org_study_id