Taurolock for Preventing Bacterial Peritonitis During Renal Insufficiency

NCT ID: NCT01101087

Last Updated: 2015-12-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-07-31

Study Completion Date

2015-12-31

Brief Summary

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Dialysis catheters are sites of bacterial proliferation. The purpose of this study is to determine whether or not the use of Taurolock (a catheter lock solution) can prevent bacterial peritonitis in patients undergoing peritoneal dialysis.

Detailed Description

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Conditions

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Peritonitis Catheter-related Infections Renal Insufficiency

Keywords

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Dialysis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Taurolock

Group Type EXPERIMENTAL

Taurolock

Intervention Type DEVICE

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

Injectable sodium chloride conditioned in exactly the same manner as the experimental product.

Interventions

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Taurolock

Intervention Type DEVICE

Placebo

Injectable sodium chloride conditioned in exactly the same manner as the experimental product.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 18 years or older
* Renal insufficiency, stage V (HAS 2007 classification)
* Requires incident peritoneal dialysis
* No signs of peritoneal infection on inclusion
* signed consent
* affiliated with a social security system

Exclusion Criteria

* Patient will have a renal transplant in the upcoming year following dialysis
* Survival prognosis for one year is weak
* allergy to citrate, (cyclo)-taurolidine, or heparin
* patient is taking medication with a known contra-indication with citrate or (cyclo)-taurolidine
* patient has a thrombopenia caused by heparin
* impossible to inform the patient correctly
* patient under guardianship
* patient already included in another biomedical research protocol
* no signed consent
* no social security system
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre Hospitalier Universitaire de Nīmes

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bernard Branger, MD

Role: PRINCIPAL_INVESTIGATOR

Centre Hospitalier Universitaire de Nîmes

Locations

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CHU de Nîmes - Hôpital Universitaire Carémeau

Nîmes, Gard, France

Site Status

CH d'Avignon - Centre Hospitalier Henri Duffaut

Avignon, , France

Site Status

CHU de Caen - Hôpital Clemenceau

Caen, , France

Site Status

CH de Chambéry

Chambéry, , France

Site Status

CH de Colmar - Hôpitaux Civils de Colmar

Colmar, , France

Site Status

Association CALYDIAL Vienne

Irigny, , France

Site Status

Centre Hospitalier Départemental Vendée - Site de la Roche sur Yon

La Roche-sur-Yon, , France

Site Status

AIDER - Clinque Jacques Mirouze

Montpellier, , France

Site Status

APHP - Groupe Hospitalier Pitié-Salpetrière

Paris, , France

Site Status

CH Pontoise - Centre Hospitalier René Dubos

Pontoise, , France

Site Status

Association AUB Santé Quimper

Quimper, , France

Site Status

Centre Hospitalier Regional - Site Groupe Hospitalier Sud Réunion (GHSR)

Saint-Pierre, , France

Site Status

CH de Valenciennes - Hôpital Jean Bernard et Hôtel Dieu

Valenciennes, , France

Site Status

ALTIR - Hôpital Brabois

Vandœuvre-lès-Nancy, , France

Site Status

Association APURAD

Paéa, , French Polynesia

Site Status

Countries

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France French Polynesia

Other Identifiers

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2009-A00599-48

Identifier Type: OTHER

Identifier Source: secondary_id

PHRC-N/2009/BB

Identifier Type: -

Identifier Source: org_study_id