A Study to Assess the Pharmacokinetics, Pharmacodynamics of ASP1941 in Diabetes Mellitus Patients With Renal Impairment

NCT ID: NCT01097681

Last Updated: 2024-11-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-02-16

Study Completion Date

2010-06-18

Brief Summary

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The primary objective of this study is to compare the pharmacokinetics of ASP1941 in type 2 diabetes mellitus patients with normal renal function and those with mild or moderate renal impairment.

Detailed Description

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Conditions

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Type 2 Diabetes Mellitus

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Normal renal function group

oral

Group Type EXPERIMENTAL

ASP1941

Intervention Type DRUG

oral

Mild renal impairment group

oral

Group Type EXPERIMENTAL

ASP1941

Intervention Type DRUG

oral

Moderate renal impairment group

oral

Group Type EXPERIMENTAL

ASP1941

Intervention Type DRUG

oral

Interventions

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ASP1941

oral

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Type 2 diabetic patients for at least 12 weeks
* Fasting plasma glucose level of \< 240 mg/dL
* Body Mass Index ( BMI )20.0 - 35.0kg/m2
* GFR value based on the Japanese GFR estimation equation at screening, of ≥ 30 ml/min/1.73m2

Exclusion Criteria

* Type 1 diabetes mellitus patients
* Receiving insulin within 12 weeks before screening
* Diabetic ketoacidosis
* Dysuria and/or urinary tract infection, genital infection
* Significant renal, hepatic or cardiovascular diseases
* Severe gastrointestinal diseases
Minimum Eligible Age

20 Years

Maximum Eligible Age

79 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Astellas Pharma Inc

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Use Central Contact

Role: STUDY_CHAIR

Astellas Pharma Inc

Locations

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Kansai, , Japan

Site Status

Kantou, , Japan

Site Status

Countries

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Japan

Related Links

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https://astellasclinicalstudyresults.com/study.aspx?ID=92

Link to results on Astellas Clinical Study Results Web site

Other Identifiers

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1941-CL-0073

Identifier Type: -

Identifier Source: org_study_id

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