Determination of the in Vitro Effects of Cationic Airway Lining Modulators (CALM) on Chronic Obstructive Pulmonary Disease (COPD) Sputum

NCT ID: NCT01096173

Last Updated: 2011-04-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

10 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-04-30

Study Completion Date

2010-10-31

Brief Summary

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This study is intended to be an evaluation of the properties of human sputum collected from patients with COPD. It is hypothesized that cationic airway lining modulators will have beneficial effects on the rheological properties of sputum derived from patients with COPD. Approximately 10 patients with COPD will collect sputum at home for 5 days. Samples will be collected and tested in laboratory tests.

Detailed Description

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Conditions

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Chronic Obstructive Pulmonary Disease

Eligibility Criteria

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Inclusion Criteria

1. Clinical and spirometric diagnosis of COPD
2. Smoking history of at least 10 pack yrs
3. Sputum production of greater than 2 tablespoons per day by patient report.

Exclusion Criteria

1. a primary diagnosis of asthma or bronchiectasis
2. a COPD exacerbation within 4 weeks
3. Inability to comply with study procedures.
Minimum Eligible Age

35 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The VA Western New York Healthcare System

FED

Sponsor Role collaborator

Buffalo Institute For Medical Research

UNKNOWN

Sponsor Role collaborator

Pulmatrix Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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VA of Western NY Healthcare System, Buffalo Institute for Medical Research

Principal Investigators

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Sanjay Sethi, MD

Role: PRINCIPAL_INVESTIGATOR

Va Western NY Healthcare, Buffalo Institute for Medical Research

Locations

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VA WNY Healthcare System

Buffalo, New York, United States

Site Status

Countries

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United States

Other Identifiers

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PUL_VABUF_01

Identifier Type: -

Identifier Source: org_study_id

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