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Response to SLT vs. ALT in Patients Under 60 Years of Age

NCT ID: NCT01087684

Last Updated: 2013-10-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

42 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-12-31

Study Completion Date

2008-12-31

Brief Summary

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Laser trabeculoplasty is a routine treatment for glaucoma and can be performed with either argon (ALT) or selective Yag (SLT) lasers. The effectiveness of each has not been studied in patients under 60 years, which is younger than average for the procedure. The study hypothesis is that there will be no difference between the two laser types.

Detailed Description

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Forty-two young patients (age 29 to 60) had one eye randomized to ALT (n = 22) or SLT (n = 20). Intraocular pressure was measured prior to laser and 1 hour, 1 day, 6 weeks, 3 months, every 3 months until 2 years, and then yearly post-laser. χ2 analysis and student's t-test were used to determine statistical significance.

Conditions

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Glaucoma

Keywords

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Glaucoma laser trabeculoplasty intraocular pressure

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Investigators

Study Groups

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Argon laser trabeculoplasty

Patients received standard argon laser treatment

Group Type ACTIVE_COMPARATOR

Argon laser trabeculoplasty

Intervention Type PROCEDURE

Argon laser 600-800 mW, 0.1seconds, 50 micron spot size, 45 - 55 burns over 180 degrees of trabecular meshwork

Selective laser trabeculoplasty

Patients received a standard selective laser treatment

Group Type ACTIVE_COMPARATOR

Selective laser trabeculoplasty

Intervention Type PROCEDURE

Selective laser trabeculoplasty 0.7 - 0.8 mJ, 400 micron spot size, 3 nanosecond, 45 - 55 burns over 180 degrees of trabecular meshwork.

Interventions

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Argon laser trabeculoplasty

Argon laser 600-800 mW, 0.1seconds, 50 micron spot size, 45 - 55 burns over 180 degrees of trabecular meshwork

Intervention Type PROCEDURE

Selective laser trabeculoplasty

Selective laser trabeculoplasty 0.7 - 0.8 mJ, 400 micron spot size, 3 nanosecond, 45 - 55 burns over 180 degrees of trabecular meshwork.

Intervention Type PROCEDURE

Other Intervention Names

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ALT SLT

Eligibility Criteria

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Inclusion Criteria

* Age \< 60 years
* Intraocular pressure not adequately controlled

Exclusion Criteria

* Prior laser treatment
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sunnybrook Health Sciences Centre

OTHER

Sponsor Role lead

Responsible Party

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Dr. Catherine Birt

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Catherine M Birt, MD

Role: PRINCIPAL_INVESTIGATOR

Sunnybrook Health Sciences Centre

Locations

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Sunnybrook Health Sciences Centre

Toronto, Ontario, Canada

Site Status

Countries

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Canada

References

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Liu Y, Birt CM. Argon versus selective laser trabeculoplasty in younger patients: 2-year results. J Glaucoma. 2012 Feb;21(2):112-5. doi: 10.1097/IJG.0b013e318202791c.

Reference Type RESULT
PMID: 21572334 (View on PubMed)

Other Identifiers

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459-2004

Identifier Type: -

Identifier Source: org_study_id